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Linaclotide Disease Interactions

There are 2 disease interactions with linaclotide:

Major

Linaclotide (Includes Linaclotide) ↔ Gastrointestinal Obstruction

Severe Potential Hazard, High plausibility

Applies to: Gastrointestinal Obstruction

The use of linaclotide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Because linaclotide accelerates gastrointestinal transit, it can exacerbate a blockage.

Moderate

Linaclotide (Includes Linaclotide) ↔ Diarrhea

Moderate Potential Hazard, Moderate plausibility

Applies to: Diarrhea, Electrolyte Abnormalities, Hypokalemia, Hyponatremia

The use of linaclotide may cause diarrhea that might be associated with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia and hyponatremia). It is recommended to withhold dosing and rehydrate patients if severe diarrhea occurs. Care should be exercised when prescribing this agent to patients at risk of diarrhea or dehydration.

linaclotide drug Interactions

There are 131 drug interactions with linaclotide

linaclotide alcohol/food Interactions

There is 1 alcohol/food interaction with linaclotide

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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