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Linaclotide Disease Interactions

There are 2 disease interactions with linaclotide.


Linaclotide (applies to linaclotide) gastrointestinal obstruction

Major Potential Hazard, High plausibility.

The use of linaclotide is contraindicated in patients with known or suspected mechanical gastrointestinal obstruction. Because linaclotide accelerates gastrointestinal transit, it can exacerbate a blockage.


  1. "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals (2012):

Linaclotide (applies to linaclotide) diarrhea

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Electrolyte Abnormalities, Hypokalemia, Hyponatremia

The use of linaclotide may cause diarrhea that might be associated with dizziness, syncope, hypotension and electrolyte abnormalities (hypokalemia and hyponatremia). It is recommended to withhold dosing and rehydrate patients if severe diarrhea occurs. Care should be exercised when prescribing this agent to patients at risk of diarrhea or dehydration.


  1. "Product Information. Linzess (linaclotide)." Forest Pharmaceuticals (2012):

Linaclotide drug interactions

There are 59 drug interactions with linaclotide.

Linaclotide alcohol/food interactions

There is 1 alcohol/food interaction with linaclotide.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.