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Ivabradine Disease Interactions

There are 5 disease interactions with ivabradine:

Major

Ivabradine (applies to ivabradine) conduction disturbances

Major Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias

The use of ivabradine is contraindicated in sick sinus syndrome, sinoatrial block, or 3rd degree AV block, unless a functioning demand pacemaker is present, in those patients that are pacemaker dependent (heart rate maintained exclusively by the pacemaker), and in patients with resting heart rate less than 60 bpm prior to treatment.

Major

Ivabradine (applies to ivabradine) heart failure

Major Potential Hazard, Moderate plausibility. Applicable conditions: Congestive Heart Failure

The use of ivabradine is contraindicated in acute decompensated heart failure.

Major

Ivabradine (applies to ivabradine) hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Ivabradine is contraindicated in patients with severe hepatic impairment as it has not been studied in this population and an increase in systemic exposure is anticipated. No dose adjustment is required in patients with mild or moderate hepatic impairment.

Major

Ivabradine (applies to ivabradine) hypotension

Major Potential Hazard, Moderate plausibility.

The use of ivabradine is contraindicated in those patients with blood pressure less than 90/50 mmHg.

Moderate

Ivabradine (applies to ivabradine) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

No dosage adjustment is required for patients with creatinine clearance 15 to 60 mL/min. Care should be exercised when using this agent in patients with creatinine clearance below 15 mL/min as no data are available.

Ivabradine drug interactions

There are 354 drug interactions with ivabradine

Ivabradine alcohol/food interactions

There is 1 alcohol/food interaction with ivabradine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.