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Corlanor (ivabradine) Disease Interactions

There are 5 disease interactions with Corlanor (ivabradine):

Major

Ivabradine (Includes Corlanor) ↔ Conduction Disturbances

Severe Potential Hazard, Moderate plausibility

Applies to: Arrhythmias

The use of ivabradine is contraindicated in sick sinus syndrome, sinoatrial block, or 3rd degree AV block, unless a functioning demand pacemaker is present, in those patients that are pacemaker dependent (heart rate maintained exclusively by the pacemaker), and in patients with resting heart rate less than 60 bpm prior to treatment.

Major

Ivabradine (Includes Corlanor) ↔ Heart Failure

Severe Potential Hazard, Moderate plausibility

Applies to: Congestive Heart Failure

The use of ivabradine is contraindicated in acute decompensated heart failure.

Major

Ivabradine (Includes Corlanor) ↔ Hepatic Impairment

Severe Potential Hazard, Moderate plausibility

Applies to: Liver Disease

Ivabradine is contraindicated in patients with severe hepatic impairment as it has not been studied in this population and an increase in systemic exposure is anticipated. No dose adjustment is required in patients with mild or moderate hepatic impairment.

Major

Ivabradine (Includes Corlanor) ↔ Hypotension

Severe Potential Hazard, Moderate plausibility

Applies to: Hypotension

The use of ivabradine is contraindicated in those patients with blood pressure less than 90/50 mmHg.

Moderate

Ivabradine (Includes Corlanor) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

No dosage adjustment is required for patients with creatinine clearance 15 to 60 mL/min. Care should be exercised when using this agent in patients with creatinine clearance below 15 mL/min as no data are available.

Corlanor (ivabradine) drug Interactions

There are 371 drug interactions with Corlanor (ivabradine)

Corlanor (ivabradine) alcohol/food Interactions

There is 1 alcohol/food interaction with Corlanor (ivabradine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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