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tedizolid (Oral route)

te-DIZ-oh-lid FOS-fate

Commonly used brand name(s)

In the U.S.

  • Sivextro

Available Dosage Forms:

  • Tablet

Therapeutic Class: Antibacterial

Chemical Class: Oxazolidinone

Uses For tedizolid

Tedizolid is used to treat bacterial skin and skin structure infections. It belongs to the family of medicines called antibiotics. It works by killing bacteria or preventing their growth.

tedizolid is available only with your doctor's prescription.

Before Using tedizolid

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tedizolid, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to tedizolid or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of tedizolid in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tedizolid in the elderly.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking tedizolid, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using tedizolid with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cholera Vaccine, Live

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of tedizolid. Make sure you tell your doctor if you have any other medical problems, especially:

  • Diarrhea—Use with caution. May make this condition worse.

Proper Use of tedizolid

Take tedizolid only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take tedizolid with or without food.

Keep using tedizolid for the full time of treatment, even if you begin to feel better after a few days. Also, it works best when there is a constant amount in the blood. To help keep the amount constant, tedizolid must be given on a regular schedule.

Dosing

The dose of tedizolid will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of tedizolid. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For treatment of skin infections:
      • Adults—200 milligrams (mg) once per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of tedizolid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If your next dose is less than 8 hours away, skip the missed dose and go back to your regular schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using tedizolid

It is very important that your doctor check your progress while you are taking tedizolid. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

If your symptoms do not improve or if they become worse, check with your doctor.

tedizolid may cause diarrhea, and in some cases it can be severe. It may also occur 2 months or more after you stop using tedizolid. If you have diarrhea that continues or gets worse, check with your doctor. Do not take any medicine to treat diarrhea without checking first with your doctor.

tedizolid Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare
  • Abdominal or stomach tenderness
  • back pain
  • blurred vision
  • chest tightness
  • chills
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • hoarseness
  • joint pain, stiffness, or swelling
  • nausea and vomiting
  • nervousness
  • pale skin
  • pounding in the ears
  • redness of the skin
  • severe abdominal or stomach cramps and pain
  • slow or fast heartbeat
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery or severe diarrhea, which may also be bloody

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Burning, numbness, tingling, or painful sensations
  • diarrhea
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet
Less common or rare
  • Blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally, upper chest
  • seeing floating spots before the eyes
  • sore mouth or tongue
  • trouble sleeping
  • white patches in the mouth or on the tongue

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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