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Striverdi Respimat (Inhalation)

Generic Name: olodaterol (Inhalation route)

oh-loe-DA-ter-ol

Inhalation route(Solution)

Salmeterol, a long-acting beta(2)-adrenergic agonists (LABA), has been shown to increase the risk of asthma-related death. This is considered a LABA class effect, and olodaterol is not indicated for asthma treatment .

Commonly used brand name(s)

In the U.S.

  • Striverdi Respimat

Available Dosage Forms:

  • Spray

Therapeutic Class: Bronchodilator

Pharmacologic Class: Beta-2 Adrenergic Agonist

Uses For Striverdi Respimat

Olodaterol is used as a maintenance treatment to treat air flow blockage in chronic obstructive pulmonary disease (COPD). This includes chronic bronchitis and emphysema.

Olodaterol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Before Using Striverdi Respimat

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Use of olodaterol is not recommended in children. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olodaterol in the elderly.

Pregnancy

Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Atenolol
  • Befunolol
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bopindolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Clomipramine
  • Desipramine
  • Dibenzepin
  • Doxepin
  • Esmolol
  • Furazolidone
  • Imipramine
  • Iproniazid
  • Isocarboxazid
  • Labetalol
  • Landiolol
  • Levobunolol
  • Linezolid
  • Lofepramine
  • Melitracen
  • Mepindolol
  • Methylene Blue
  • Metipranolol
  • Metoprolol
  • Moclobemide
  • Nadolol
  • Nebivolol
  • Nipradilol
  • Nortriptyline
  • Opipramol
  • Oxprenolol
  • Pargyline
  • Penbutolol
  • Phenelzine
  • Pindolol
  • Procarbazine
  • Propranolol
  • Protriptyline
  • Rasagiline
  • Selegiline
  • Sotalol
  • Talinolol
  • Tertatolol
  • Tianeptine
  • Timolol
  • Tranylcypromine
  • Trimipramine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma—Use is not recommended in patients with this condition.
  • Diabetes or
  • Heart or blood vessel disease (eg, coronary insufficiency, obstructive cardiomyopathy) or
  • Heart rhythm problems (eg, arrhythmia, QT prolongation) or
  • High blood pressure or
  • Low potassium levels in the blood or
  • Overactive thyroid or
  • Seizures—Use with caution. May make these conditions worse.

Proper Use of Striverdi Respimat

This medicine is used with a special inhaler and usually comes with patient directions or a Medication Guide. Read the directions carefully before using this medicine. If you do not understand the directions or you are not sure how to use the inhaler, ask your doctor or pharmacist to show you what to do.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine or any asthma medicine without telling your doctor. To do so may increase the chance for breathing problems.

Use this medicine at the same time each day.

Do not stop using this medicine or other breathing medicines that your doctor has prescribed for you unless you have discussed this with your doctor.

When you use the inhaler for the first time, or if you have not used it for 3 days or longer, it may not deliver the right amount of medicine with the first puff. Therefore, before using the inhaler, prime it by spraying the medicine four times into the air away from the face.

To use the inhaler:

  • Take the inhaler and cartridge out of the carton before you use it for the first time.
  • Do not use the inhaler for this medicine with any other medicine.
  • Push the narrow end of the cartridge into the inhaler. About 1/8 of an inch will remain visible when the cartridge is correctly inserted.
  • Do not turn the clear base before inserting the cartridge.
  • Do not remove the cartridge once it has been inserted in the inhaler.
  • Flip the yellow cap until it snaps fully open. Turn the clear base in the direction of the black arrows on the label until it clicks (half a turn).
  • Prime the inhaler before use by releasing 4 test sprays.
  • To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece fully into your mouth and close your lips around it. Do not block the mouthpiece with your teeth or tongue.
  • While pressing down firmly and fully on the dose release button of the inhaler, breathe in through your mouth as deeply as you can until you have taken a full deep breath.
  • Repeat these steps for the next puff.
  • Close the yellow cap after taking your medicine.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For inhalation dosage form (spray):
    • For maintenance treatment of COPD:
      • Adults—Two puffs once a day. Do not use more than 2 puffs every 24 hours.
      • Children—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away the inhaler 3 months after its first use.

Precautions While Using Striverdi Respimat

If you will be using this medicine for a long time, it is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

This medicine should not be used together with similar inhaled medicines, such as albuterol, isoproterenol, metaproterenol, pirbuterol, or terbutaline.

Tell your doctor if you are also using other medicines for your COPD.

This medicine should not be used if you are having a severe asthma or COPD attack, or if symptoms of a asthma or COPD attack has already started. Your doctor may prescribe another medicine for you to use in case of an acute COPD attack. If the other medicine does not work as well, tell your doctor right away.

Talk with your doctor or get medical care right away if:

  • Your symptoms do not improve after using this medicine or if they become worse.
  • Your short-acting inhaler does not seem to work as well as it used to and you need it more often than normal.
  • You have a big decrease in your peak flow when measured as directed by your doctor.

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Check with your doctor right away if you have coughing, difficulty breathing, shortness of breath, or wheezing after using this medicine.

Hypokalemia (low potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you have more than one of the following symptoms: convulsions, decreased urine, dry mouth, increased thirst, irregular heartbeat, loss of appetite, mood changes, muscle pain or cramps, nausea or vomiting, numbness or tingling in the hands, feet, or lips, shortness of breath, or unusual tiredness or weakness.

This medicine may cause serious allergic reactions, including angioedema. Angioedema may be life-threatening and requires immediate medical attention. Check with your doctor right away if you have a rash, itching, a large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, trouble breathing, or chest tightness while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Striverdi Respimat Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known
  • Blurred vision
  • chest pain
  • convulsions
  • difficulty with breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fruit-like breath odor
  • hives
  • increased blood pressure
  • increased thirst or urination
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • muscle spasm or weakness
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • swelling of the eyes, face, or inside of the nose
  • sudden shortness of breath
  • tightness in the chest

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Back or joint pain
  • bloody or cloudy urine
  • cough
  • diarrhea
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
  • rash
  • runny nose
  • sneezing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

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