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Medications for Myasthenia Gravis

Treatments for myasthenia gravis depend on your age, disease severity, and how fast it is progressing and may include neostigmine (Bloxiverz) or pyridostigmine (Mestinon, Regonal); corticosteroids such as prednisone; immunosuppressants such as azathioprine (Azasan, Imuran), mycophenolate mofetil (Cellcept), cyclosporine (Gengraf, NeoralSandimmune), methotrexate (Trexall, Xatmep) or tacrolimus (Astagraf XL, Prograf); plasmapheresis; IV or SQ immunoglobulin (IVIG or SCIG) infusions; efgartigimod alfa (Vyvgart) or efgartigimod alfa-hyaluronidase (Vyvgart Hytrulo); monoclonal antibodies, such as rituximab (Rituxan), eculizumab (Soliris), ravulizumab (Ultomiris); other medications such as rozanolixizumab-noli (Rystiggo) or zilucoplan (Zilbrysq); or surgery to remove the thymus gland.

Drugs used to treat Myasthenia Gravis

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Mestinon 6.7 22 reviews for Mestinon to treat Myasthenia Gravis
Rx C N
Generic name:
pyridostigmine systemic
Drug class:
cholinergic muscle stimulants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
pyridostigmine 7.2 33 reviews for pyridostigmine to treat Myasthenia Gravis
Rx C N
Generic name:
pyridostigmine systemic
Brand names:
Mestinon, Regonol
Drug class:
cholinergic muscle stimulants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Soliris 7.0 2 reviews for Soliris to treat Myasthenia Gravis
Rx C N
Generic name:
eculizumab systemic
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Vyvgart 8.2 10 reviews for Vyvgart to treat Myasthenia Gravis
Rx N
Generic name:
efgartigimod alfa systemic
Drug class:
immune globulins
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Ultomiris 10 4 reviews for Ultomiris to treat Myasthenia Gravis
Rx N
Generic name:
ravulizumab systemic
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
efgartigimod alfa 8.2 10 reviews for efgartigimod alfa to treat Myasthenia Gravis
Rx N
Generic name:
efgartigimod alfa systemic
Brand name:
Vyvgart
Drug class:
immune globulins
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
azathioprine Off-label 7.2 6 reviews for azathioprine to treat Myasthenia Gravis
Rx D N
Generic name:
azathioprine systemic
Drug class:
antirheumatics, other immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
rozanolixizumab 8.0 2 reviews for rozanolixizumab to treat Myasthenia Gravis
Rx N
Generic name:
rozanolixizumab systemic
Brand name:
Rystiggo
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Rystiggo 8.0 2 reviews for Rystiggo to treat Myasthenia Gravis
Rx N
Generic name:
rozanolixizumab systemic
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Zilbrysq Rate Add review
Rx N
Generic name:
zilucoplan systemic
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
zilucoplan Rate Add review
Rx N
Generic name:
zilucoplan systemic
Brand name:
Zilbrysq
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
mycophenolate mofetil Off-label 7.7 16 reviews for mycophenolate mofetil to treat Myasthenia Gravis
Rx D N
Generic name:
mycophenolate mofetil systemic
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
neostigmine 10 1 review for neostigmine to treat Myasthenia Gravis
Rx C N
Generic name:
neostigmine systemic
Drug class:
cholinergic muscle stimulants, miscellaneous genitourinary tract agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Regonol Rate Add review
Rx C N
Generic name:
pyridostigmine systemic
Drug class:
cholinergic muscle stimulants
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
immune globulin intravenous Off-label 4.5 3 reviews for immune globulin intravenous to treat Myasthenia Gravis
Rx C N
Generic name:
immune globulin intravenous systemic
Drug class:
immune globulins
For consumers:
dosage, interactions, side effects
Off-label:
Yes
eculizumab 7.0 2 reviews for eculizumab to treat Myasthenia Gravis
Rx C N
Generic name:
eculizumab systemic
Brand name:
Soliris
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
ephedrine Off-label Rate Add review
Rx/OTC C N
Generic name:
ephedrine systemic
Drug class:
vasopressors, decongestants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
ravulizumab 10 4 reviews for ravulizumab to treat Myasthenia Gravis
Rx N
Generic name:
ravulizumab systemic
Brand name:
Ultomiris
Drug class:
selective immunosuppressants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
efgartigimod alfa / hyaluronidase Rate Add review
Rx N
Generic name:
efgartigimod alfa / hyaluronidase systemic
Brand name:
Vyvgart Hytrulo
Drug class:
immune globulins
For consumers:
dosage, interactions, side effects
Vyvgart Hytrulo Rate Add review
Rx N
Generic name:
efgartigimod alfa / hyaluronidase systemic
Drug class:
immune globulins
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

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Alternative treatments for Myasthenia Gravis

The following products are considered to be alternative treatments or natural remedies for Myasthenia Gravis. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Myasthenia Gravis.

Learn more about Myasthenia Gravis

Care guides

Symptoms and treatments

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.