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Pyridostigmine Dosage

Medically reviewed by Drugs.com. Last updated on Nov 11, 2024.

Applies to the following strengths: 5 mg/mL; 180 mg; 60 mg; 60 mg/5 mL; 30 mg

Usual Adult Dose for Myasthenia Gravis

Immediate-release tablets and syrup: 60 to 1500 mg daily (usually 600 mg/day divided into 5 or 6 doses) spaced to provide maximum relief

Sustained-release: 180 to 540 mg once or twice daily (separated by at least 6 hours); it may be necessary to use the immediate-release tablets or oral solution in conjunction with the sustained-release tablets for optimum control

Comments:


Use: Myasthenia gravis

Usual Adult Dose for Reversal of Nondepolarizing Muscle Relaxants

The IV dose should be individualized. The dosage information presented here is derived from studies based upon units of drug per unit of body weight and is intended to serve as a guide only:


Comments:

Use: As a reversal agent or antagonist to the neuromuscular blocking effects of nondepolarizing muscle relaxants

Usual Adult Dose for Nerve Agent Pretreatment

Soman pretreatment:
30 mg orally every 8 hours starting at least several hours prior to exposure to soman; pretreatment has been used for up to 14 to 21 days


Comments:

Use: For pretreatment against the lethal effects of soman nerve agent poisoning in conjunction with protective garments, including a mask. At the first sign of nerve agent poisoning, this drug should be stopped, and atropine and pralidoxime (2-PAM) therapy started immediately.

Renal Dose Adjustments

Lower doses may be required; however, no specific guidelines have been suggested. Caution recommended.

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNINGS:

CAUTION: THIS DRUG IS USED AS A PRETREATMENT ONLY FOR SOMAN EXPOSURE; AFTER EXPOSURE TO SOMAN, USE ATROPINE AND 2-PAM (ALWAYS WEAR PROTECTIVE GARMENTS):

CONTRAINDICATIONS:

This drug is not recommended for use in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

General:


Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.