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Pyridostigmine Injection

Generic name: Pyridostigmine Injection [ peer-id-oh-STIG-meen ]
Brand name: Regonol
Drug class: Cholinergic muscle stimulants

Medically reviewed by Last updated on Feb 16, 2023.

Uses of Pyridostigmine Injection:

  • It is used to get back function in muscles after surgery.
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Pyridostigmine Injection?

  • If you are allergic to pyridostigmine injection; any part of pyridostigmine injection; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have bowel block or trouble passing urine.
  • If the patient is a newborn or infant. This medicine has benzyl alcohol in it. Benzyl alcohol may cause severe and sometimes deadly side effects in newborns or infants. Do not give pyridostigmine injection to a newborn or infant.

This is not a list of all drugs or health problems that interact with pyridostigmine injection.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take pyridostigmine injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Pyridostigmine Injection?

  • Tell all of your health care providers that you take pyridostigmine injection. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not take more than what your doctor told you to take. Unsafe effects, including death, may happen.
  • This medicine is not approved for use in children. However, the doctor may decide the benefits of taking pyridostigmine injection outweigh the risks. If your child has been given pyridostigmine injection, ask the doctor for information about the benefits and risks. Talk with the doctor if you have questions about giving pyridostigmine injection to your child.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Pyridostigmine Injection) best taken?

Use pyridostigmine injection as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as a shot into a vein.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Muscle weakness that is new or worse.
  • Trouble breathing that is new or worse.
  • Upset stomach or throwing up.
  • Stomach cramps.
  • Diarrhea.
  • More saliva.
  • Small pupils.
  • Sweating a lot.
  • Muscle cramps.
  • Twitching.
  • Slow heartbeat.

What are some other side effects of Pyridostigmine Injection?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Pyridostigmine Injection?

  • If you need to store pyridostigmine injection at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about pyridostigmine injection, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.