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Vyvgart

Pronunciation: VIV-gart
Generic name: efgartigimod alfa
Dosage form: injection for intravenous infusion (400 mg/20 mL)
Drug class: Immune globulins

Medically reviewed by Carmen Pope, BPharm. Last updated on July 8, 2025.

What is Vyvgart?

Vyvgart is used to treat generalized myasthenia gravis (gMG) in adults who are anti-acetylcholine receptor (AChR) antibody positive. It is given as an intravenous infusion once a week for 4 weeks.

Vyvgart works by attaching to and blocking a protein called neonatal Fc receptor (FcRn), which binds circulating IgG antibodies. By occupying these receptors, Vyvgart prevents harmful antibodies from binding, allowing the body to naturally remove them faster. This helps conditions such as gMG, where harmful antibodies damage nerves and muscles.

This medication guide covers Vyvgart, which first gained FDA approval on December 17, 2021, for gMG. Vyvgart Hytrulo is a formulation of Vyvgart containing hyaluronidase that can be given subcutaneously (see Vyvgart Hytrulo for more information).

Side effects

The most common side effects of Vyvgart are:

Serious side effects and warnings

Vyvgart can cause the following serious side effects:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before receiving this medicine

Do not receive Vyvgart if you are allergic to efgartigimod alfa, Vyvgart, Vyvgart Hytrulo, or any of the inactive ingredients in the preparation. Vyvgart can cause serious allergic reactions and a decrease in blood pressure leading to fainting.

To make sure Vyvgart is safe for you, tell your doctor if you:

How is Vyvgart administered?

Vyvgart is administered intravenously (into a vein) by a healthcare provider in their clinic.

Dosing information

Dose of Vyvgart for gMG in adults

Subsequent treatment cycles may be administered based on clinical evaluation.

What happens if I miss a dose?

If you miss a dose, ring your healthcare provider to reschedule. The infusion may be administered up to 3 days after the scheduled time. Resume the original dosing schedule until the treatment cycle is completed.

What should I avoid while receiving Vyvgart?

You should avoid receiving live vaccines, such as chickenpox, measles, or mumps while you are being treated with this medicine.

What other drugs will affect Vyvgart?

Vyvgart may interact with other prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use, and when you start, stop, or change a dose of any medicine.

Care should be taken when using Vyvgart with other medications that bind to the human neonatal Fc receptor (FcRn) (such as immunoglobulin products, monoclonal antibodies, or antibody derivates containing the human Fc domain of the IgG subclass) because it may reduce the effectiveness of these medications.

Does Vyvgart interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Ingredients

Active ingredients: efgartigimod alfa 20 mg/mL

Inactive ingredients: Arginine hydrochloride, polysorbate 80, sodium chloride, sodium phosphate, dibasic, anhydrous, sodium phosphate, monobasic, monohydrate, and water for injection.

Vyvgart is available as a 400 mg in 20 mL (20 mg/mL) injection in a single-dose vial.

Manufacturer

Vyvgart is made by Argenx BV, Industriepark 7, 9052 Zwijnaarde, Belgium, and distributed by Argenx US, Inc., 33 Arch Street, Boston, MA 02110.

Vyvgart Biosimilars

Biosimilar and interchangeable products are biological products that are highly similar to and have no clinically meaningful differences from the reference product.

Reference products

These are biological products that have already been approved by the FDA, against which biosimilar products are compared. There is 1 for Vyvgart.

Vyvgart (efgartigimod alfa-fcab) - Argenx BV
Formulation type Strength
Single-Dose Vial 400 mg/20 mL (20 mg/mL)

Popular FAQ

What is the difference between Vyvgart and Vyvgart Hytrulo?

Vyvgart and Vyvgart Hytrulo both contain the same active ingredient, efgartigimod, but there are differences in their uses and the way they are given, for example Vyvgart Hytrulo can be self-administered using a prefilled syringe for subcutaneous (SC) injection, whereas Vyvgart must be given by intravenous (IV) infusion by a healthcare provider.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.