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Generic name: neostigmine [ nee-o-STIG-meen ]
Brand names: Bloxiverz, Prostigmin Bromide, Prostigmin
Dosage forms: injectable solution (1 mg/mL), intravenous solution (0.5 mg/mL; 1 mg/mL)
Drug classes: Cholinergic muscle stimulants, Miscellaneous genitourinary tract agents

Medically reviewed by on Oct 3, 2023. Written by Cerner Multum.

What is neostigmine?

Neostigmine is used to reverse the effects of anesthesia medications used during surgery.

Neostigmine may also be used for purposes not listed in this medication guide.

Neostigmine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have muscle weakness as you wake up from surgery.

Common side effects of neostigmine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not be treated with neostigmine if you have a bladder or bowel obstruction, or a serious disorder called peritonitis (inflammation of the membrane lining the organs inside your abdomen).

Before taking this medicine

You should not be treated with neostigmine if you are allergic to it, or if you have:

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How is neostigmine given?

Neostigmine is given as an infusion into a vein. A healthcare provider will give you this injection.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely.

Your doctor will also test your reflexes to make sure neostigmine is effective in reversing the anesthesia.

What happens if I miss a dose?

Because is used when needed only for surgery, it does not have a daily dosing schedule.

What happens if I overdose?

Since neostigmine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving neostigmine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect neostigmine?

Other drugs may affect neostigmine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.