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Xadago Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Xadago (safinamide) Carbidopa / levodopa Sinemet (carbidopa / levodopa)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Xadago (safinamide) Carbidopa / levodopa Sinemet (carbidopa / levodopa)
Prescription only

Prescribed for Parkinson's Disease. Xadago may also be used for purposes not listed in this medication guide.

Prescription only

Carbidopa/levodopa is a medication that may be used for the treatment of Parkinson's disease. Available as immediate-release tablets, extended-release tablets, and extended-release capsules... View more

Prescription only

Sinemet is a medication that may be used for the treatment of Parkinson's disease that is available in three different strengths: Sinemet 25/100, Sinemet 25/250, and Sinemet 10/100. Dyskinesias... View more

Related suggestions
More about Xadago (safinamide) More about Carbidopa / levodopa More about Sinemet (carbidopa / levodopa)
Ratings & Reviews

Xadago has an average rating of 10.0 out of 10 from a total of 4 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect.

Carbidopa / levodopa has an average rating of 7.2 out of 10 from a total of 94 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 20% reported a negative effect.

Sinemet has an average rating of 7.7 out of 10 from a total of 30 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 10% reported a negative effect.

View all 4 reviews

View all 94 reviews

View all 30 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Xadago side effects

View all Carbidopa / levodopa side effects

View all Sinemet side effects
Drug Class
Generic Availability

Lower cost generic approved

Lower cost generic

Lower cost generic approved
Pricing and Coupons * Prices are without insurance
Quantity 30 tablet
Strength 50 mg
Per unit* $40.88
Cost* $1,226.43

View all Xadago prices

Quantity 100 each
Strength 25 mg-100 mg
Per unit* $0.26 - $0.67
Cost* $25.83 - $67.40

View all Carbidopa / levodopa prices

Quantity 100 tablet
Strength 25 mg-100 mg
Per unit* $1.61
Cost* $160.78

View all Sinemet prices

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Dosage Forms
  • Oral tablet
  • Oral tablet
  • Oral tablet, disintegrating
  • Oral tablet, extended release
  • Oral tablet
Brand Names

N/A

 Atamet, Crexont, Dhivy, Duopa, Parcopa, Rytary, Sinemet Other carbidopa / levodopa brands include: Atamet, Crexont, Dhivy, Duopa, Parcopa, Rytary
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

30 hours

2.3 hours

2.3 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category

Summary unavailable.

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
Drug Interactions

A total of 487 drugs are known to interact with Xadago:

  • 72 major drug interactions (303 brand and generic names)
  • 413 moderate drug interactions (1768 brand and generic names)
  • 2 minor drug interactions (4 brand and generic names)

A total of 520 drugs are known to interact with Carbidopa / levodopa:

  • 50 major drug interactions (158 brand and generic names)
  • 459 moderate drug interactions (3234 brand and generic names)
  • 11 minor drug interactions (111 brand and generic names)

A total of 520 drugs are known to interact with Sinemet:

  • 50 major drug interactions (158 brand and generic names)
  • 459 moderate drug interactions (3234 brand and generic names)
  • 11 minor drug interactions (111 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Safinamide may be taken with or without food. While there is no need to strictly avoid most foods... View more
  • Using safinamide together with alcohol may increase side effects such as dizziness, drowsiness... View more
  • Alcohol can increase the nervous system side effects of levodopa such as dizziness, drowsiness, and... View more
  • Alcohol can increase the nervous system side effects of levodopa such as dizziness, drowsiness, and... View more
Disease Interactions
First Approval Date

March 21, 2017

May 02, 1975

May 02, 1975
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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