Tikosyn Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Tikosyn (dofetilide)	Amiodarone	Propranolol	Enter another drug to compare

Tikosyn (dofetilide)

Amiodarone

Propranolol

Prescription only

Prescribed for Arrhythmia. Tikosyn may also be used for purposes not listed in this medication guide.

Prescription only

Amiodarone should ONLY be used in the treatment of life-threatening ventricular arrhythmias that have not responded to other treatments. Amiodarone does not appear to increase life expectancy and can... View more

Prescription only

Propranolol is mainly used for blood pressure and angina control; however, it also has a role in migraine prevention and the treatment of essential tremor. Propranolol may cause vivid dreams and is... View more

More about Tikosyn (dofetilide)

More about Amiodarone

More about Propranolol

Ratings & Reviews

Tikosyn has an average rating of 7.7 out of 10 from a total of 62 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 15% reported a negative effect.

Amiodarone has an average rating of 4.9 out of 10 from a total of 95 ratings on Drugs.com. 39% of reviewers reported a positive effect, while 48% reported a negative effect.

Propranolol has an average rating of 8.2 out of 10 from a total of 1378 ratings on Drugs.com. 77% of reviewers reported a positive effect, while 12% reported a negative effect.

View all 62 reviews

View all 95 reviews

View all 1378 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Fatigue (11.3%)
Headaches (11.3%)
Heart palpitations (8.1%)
Tiredness (8.1%)
Dizziness (6.5%)
Increased heart rate (6.5%)
Insomnia (4.8%)

View all Tikosyn side effects

Tiredness (14.7%)
Dizziness (10.5%)
Insomnia (10.5%)
Shortness of breath (10.5%)
Weakness (6.3%)
Constipation (5.3%)
Cough (5.3%)

View all Amiodarone side effects

Tremors (10.4%)
Anxiety (6.7%)
Tiredness (6.6%)
Increased heart rate (6.5%)
Dizziness (5.2%)
Sweating (4.9%)
Headaches (4.1%)

View all Propranolol side effects

Drug Class

Group III antiarrhythmics

Group III antiarrhythmics

Generic Availability

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	60 capsule
Strength	125 mcg
Per unit^*	$12.11
Cost^*	$726.86

View all Tikosyn prices

Quantity	100 each
Strength	200 mg
Per unit^*	$0.28 - $0.52
Cost^*	$27.86 - $52.44

View all Amiodarone prices

Quantity	50 each
Strength	20 mg
Per unit^*	$0.35
Cost^*	$17.39

View all Propranolol prices

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Dosage Forms

Oral capsule

Intravenous solution
Oral tablet

Intravenous solution
Oral capsule, extended release
Oral solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

10 hours

240 hours

6.4 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 423 drugs are known to interact with Tikosyn:

252 major drug interactions (820 brand and generic names)
151 moderate drug interactions (736 brand and generic names)
20 minor drug interactions (202 brand and generic names)

A total of 746 drugs are known to interact with Amiodarone:

279 major drug interactions (953 brand and generic names)
429 moderate drug interactions (1619 brand and generic names)
38 minor drug interactions (191 brand and generic names)

A total of 590 drugs are known to interact with Propranolol:

47 major drug interactions (215 brand and generic names)
493 moderate drug interactions (3297 brand and generic names)
50 minor drug interactions (611 brand and generic names)

Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Amiodarone may be taken with or without food but should be taken at the same way each time. You... View more

Food can enhance the levels of propranolol in your body. You shoud take propranolol at the same... View more

Disease Interactions

First Approval Date

October 01, 1999

December 24, 1985

November 13, 1967

WADA Class View classifications

N/A

P1 - Beta-Blockers

More Information

Patient Resources

Tikosyn uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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