Comparing St. John's Wort vs Zoloft
| St. john's wort | Zoloft (sertraline) |
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| St. john's wort | Zoloft (sertraline) |
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Over-the-counter
Used for Depression, Night Terrors. St. john's wort may also be used for purposes not listed in this medication guide. |
Prescription only
Zoloft is a brand name for sertraline which is an effective antidepressant with less potential for drowsiness than many other antidepressants. It belongs to the group of medicines called selective... View more |
Related suggestions Depression
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| More about St. john's wort | More about Zoloft (sertraline) | ||||||||
| Ratings & Reviews | |||||||||
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St. john's wort has an average rating of 7.8 out of 10 from a total of 144 ratings on Drugs.com. 74% of reviewers reported a positive effect, while 15% reported a negative effect. |
Zoloft has an average rating of 7.3 out of 10 from a total of 1973 ratings on Drugs.com. 64% of reviewers reported a positive effect, while 18% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all St. john's wort side effects |
View all Zoloft side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
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| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Zoloft prices |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
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N/A |
N/A |
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| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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N/A |
66 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||
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Category N
Not classified
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Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 635 drugs are known to interact with St. john's wort:
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A total of 673 drugs are known to interact with Zoloft:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
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No known disease interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| First Approval Date | |||||||||
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N/A |
December 30, 1991 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.