Safinamide Alternatives Compared
| Safinamide | Carbidopa / levodopa | Amantadine |
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| Safinamide | Carbidopa / levodopa | Amantadine |
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Prescription only
Prescribed for Parkinson's Disease. Safinamide may also be used for purposes not listed in this medication guide. |
Prescription only
Carbidopa/levodopa is a medication that may be used for the treatment of Parkinson's disease. Available as immediate-release tablets, extended-release tablets, and extended-release capsules... View more |
Prescription only
Amantadine may be used to treat dyskinesia or reduce the number of OFF episodes in those with Parkinson's disease (PD) OR in the treatment or prevention of Influenza A viral infection. Nausea... View more |
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| More about Safinamide | More about Carbidopa / levodopa | More about Amantadine | ||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||
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Safinamide has an average rating of 10.0 out of 10 from a total of 4 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. |
Carbidopa / levodopa has an average rating of 7.2 out of 10 from a total of 96 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 20% reported a negative effect. |
Amantadine has an average rating of 6.9 out of 10 from a total of 56 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||||||||||
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View all Safinamide side effects |
View all Carbidopa / levodopa side effects |
View all Amantadine side effects |
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| Drug Class | ||||||||||||||||||
| Generic Availability | ||||||||||||||||||
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N/A |
Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Carbidopa / levodopa prices |
View all Amantadine prices |
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| Dosage Forms | ||||||||||||||||||
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N/A |
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| Brand Names | ||||||||||||||||||
| Xadago | Atamet, Crexont, Dhivy, Duopa, Parcopa, Rytary, Sinemet | Gocovri, Osmolex ER | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||||||||||
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30 hours |
2.3 hours |
19 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||
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A total of 488 drugs are known to interact with Safinamide:
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A total of 521 drugs are known to interact with Carbidopa / levodopa:
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A total of 131 drugs are known to interact with Amantadine:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||
| First Approval Date | ||||||||||||||||||
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March 21, 2017 |
May 02, 1975 |
February 14, 1968 |
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| WADA Class View classifications | ||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||
| Patient Resources | ||||||||||||||||||
| Professional Resources | ||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.