Safinamide Disease Interactions
There are 5 disease interactions with safinamide:
Dopamine agonists (Includes safinamide) ↔ hypotension
Severe Potential Hazard, Moderate plausibility. Applies to: Hypotension
Dopamine agonists may impair the systemic regulation of blood pressure, with resultant orthostatic hypotension, especially during dose escalation. Therapy with dopamine agonists should be monitored carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs.
- "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Sinemet CR (carbidopa-levodopa)." Dupont Pharmaceuticals, Wilmington, DE.
- Iwasaki S, Hamaguchi K, Iwasaki A, Takakusagi M, Narabayashi Y "Hypotensive effect of long-term levodopa in patients with Parkinson's disease." Eur Neurol 30 (1990): 194-9
- "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim, Ridgefield, CT.
- Hoehn MM "Levodopa-induced postural hypotension. Treatment with fludrocortisone." Arch Neurol 32 (1975): 50-1
- "Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals, Wilmington, DE.
Dopaminergic antiparkinson agents (Includes safinamide) ↔ psychosis
Severe Potential Hazard, Moderate plausibility. Applies to: Psychosis
Ordinarily, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of exacerbating psychosis. Hallucinations and psychotic-like behavior have been reported with dopaminergic medications. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of these drugs.
Safinamide (Includes safinamide) ↔ hepatic impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Liver Disease
Safinamide is contraindicated in patients with severe hepatic dysfunction (Child-Pugh C). In patients with moderate hepatic impairment the maximum recommended dose is 50 mg orally once a day. If a patient taking this dose progresses from moderate to severe hepatic impairment, safinamide should be discontinued.
Safinamide (Includes safinamide) ↔ hypertension
Moderate Potential Hazard, Moderate plausibility. Applies to: Hypertension
Safinamide may cause hypertension or exacerbate existing hypertension. Patients should be monitored for new onset hypertension or hypertension that is not adequately controlled after starting treatment. Dosage adjustment may be necessary if elevation of blood pressure is sustained.
Safinamide (Includes safinamide) ↔ retinal pathology
Moderate Potential Hazard, Moderate plausibility. Applies to: Retinal Disorder, Uveitis
Animal studies with safinamide showed retinal degeneration, loss of photoreceptor cells, cataracts, and retinal scarring. Patients should be periodically monitored for visual changes, especially if they have a history of retinal/macular degeneration, uveitis, inherited retinal conditions, family history of retinal disease, albinism, retinitis pigmentosa, or active retinopathy (e.g., diabetic retinopathy).
Safinamide drug interactions
There are 710 drug interactions with safinamide
Safinamide alcohol/food interactions
There are 2 alcohol/food interactions with safinamide
More about safinamide
- Safinamide Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 2 Reviews
- Drug class: dopaminergic antiparkinsonism agents
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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