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Safinamide Disease Interactions

There are 5 disease interactions with safinamide.

Major

Dopamine agonists (applies to safinamide) hypotension

Major Potential Hazard, Moderate plausibility.

Dopamine agonists may impair the systemic regulation of blood pressure, with resultant orthostatic hypotension, especially during dose escalation. Therapy with dopamine agonists should be monitored carefully in patients with Parkinson's disease since they may have an impaired ability to respond to an orthostatic challenge, and also in patients receiving antihypertensive drugs.

References

  1. Hoehn MM "Levodopa-induced postural hypotension. Treatment with fludrocortisone." Arch Neurol 32 (1975): 50-1
  2. Iwasaki S, Hamaguchi K, Iwasaki A, Takakusagi M, Narabayashi Y "Hypotensive effect of long-term levodopa in patients with Parkinson's disease." Eur Neurol 30 (1990): 194-9
  3. "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn PROD (2001):
  4. "Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals PROD (2001):
  5. "Product Information. Sinemet CR (carbidopa-levodopa)." DuPont Pharmaceuticals PROD (2001):
  6. "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim PROD (2001):
  7. "Product Information. Requip (ropinirole)." SmithKline Beecham PROD (2001):
  8. "Product Information. Comtan (entacapone)." Novartis Pharmaceuticals PROD (2001):
  9. "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA (2006):
  10. "Product Information. Neupro (rotigotine)." Schwarz Pharma (2007):
  11. "Product Information. Xadago (safinamide)." US WorldMeds LLC (2017):
View all 11 references
Major

Dopaminergic antiparkinson agents (applies to safinamide) psychosis

Major Potential Hazard, Moderate plausibility.

Ordinarily, patients with major psychotic disorder should not be treated with dopaminergic antiparkinson agents, because of the risk of exacerbating psychosis. Hallucinations and psychotic-like behavior have been reported with dopaminergic medications. In addition, certain medications used to treat psychosis may exacerbate the symptoms of Parkinson's disease and may decrease the effectiveness of these drugs.

References

  1. "Product Information. Dostinex (cabergoline)." Pharmacia and Upjohn PROD (2001):
  2. "Product Information. Mirapex (pramipexole)." Boehringer Ingelheim PROD (2001):
  3. "Product Information. Requip (ropinirole)." SmithKline Beecham PROD (2001):
  4. "Product Information. Comtan (entacapone)." Novartis Pharmaceuticals PROD (2001):
  5. "Product Information. Lodosyn (carbidopa)." DuPont Pharma PROD (2001):
  6. "Product Information. Azilect (rasagiline)." Teva Pharmaceuticals USA (2006):
  7. "Product Information. Neupro (rotigotine)." Schwarz Pharma (2007):
  8. "Product Information. Xadago (safinamide)." US WorldMeds LLC (2017):
View all 8 references
Major

Safinamide (applies to safinamide) hepatic impairment

Major Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Safinamide is contraindicated in patients with severe hepatic dysfunction (Child-Pugh C). In patients with moderate hepatic impairment the maximum recommended dose is 50 mg orally once a day. If a patient taking this dose progresses from moderate to severe hepatic impairment, safinamide should be discontinued.

References

  1. "Product Information. Xadago (safinamide)." US WorldMeds LLC (2017):
Moderate

Safinamide (applies to safinamide) hypertension

Moderate Potential Hazard, Moderate plausibility.

Safinamide may cause hypertension or exacerbate existing hypertension. Patients should be monitored for new onset hypertension or hypertension that is not adequately controlled after starting treatment. Dosage adjustment may be necessary if elevation of blood pressure is sustained.

References

  1. "Product Information. Xadago (safinamide)." US WorldMeds LLC (2017):
Moderate

Safinamide (applies to safinamide) retinal pathology

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Retinal Disorder, Uveitis

Animal studies with safinamide showed retinal degeneration, loss of photoreceptor cells, cataracts, and retinal scarring. Patients should be periodically monitored for visual changes, especially if they have a history of retinal/macular degeneration, uveitis, inherited retinal conditions, family history of retinal disease, albinism, retinitis pigmentosa, or active retinopathy (e.g., diabetic retinopathy).

References

  1. "Product Information. Xadago (safinamide)." US WorldMeds LLC (2017):

Safinamide drug interactions

There are 481 drug interactions with safinamide.

Safinamide alcohol/food interactions

There are 3 alcohol/food interactions with safinamide.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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