Comparing Nucynta vs Nucynta ER

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nucynta (tapentadol)	Nucynta ER (tapentadol)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Nucynta (tapentadol)	Nucynta ER (tapentadol)	Enter another drug to compare
Prescription only Prescribed for Pain. Nucynta may also be used for purposes not listed in this medication guide.	Prescription only Prescribed for Diabetic Peripheral Neuropathy, Pain. Nucynta ER may also be used for purposes not listed in this medication guide.	Related suggestions Pain Tramadol Gabapentin Ibuprofen Acetaminophen Oxycodone Tylenol
More about Nucynta (tapentadol)	More about Nucynta ER (tapentadol)
Ratings & Reviews
Nucynta has an average rating of 6.3 out of 10 from a total of 279 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 28% reported a negative effect.	Nucynta ER has an average rating of 7.2 out of 10 from a total of 81 ratings on Drugs.com. 67% of reviewers reported a positive effect, while 19% reported a negative effect.
View all 279 reviews	View all 81 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Headaches (10.8%) Nausea (9.7%) Dizziness (8.2%) Insomnia (7.2%) Drowsiness (6.5%) Tiredness (5.4%) Anxiety (5.0%) View all Nucynta side effects	Nausea (7.4%) Constipation (4.9%) Dizziness (4.9%) Drowsiness (4.9%) Insomnia (4.9%) Tiredness (4.9%) Pain (3.7%) View all Nucynta ER side effects
Drug Class
Opioids (narcotic analgesics)	Opioids (narcotic analgesics)
Generic Availability
No lower cost generic approved	No lower cost generic approved
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral tablet	Oral tablet, extended release
Brand Names
Other tapentadol brands include: Nucynta ER	Other tapentadol brands include: Nucynta
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
4 hours	4 hours
CSA Schedule ¹ View glossary of CSA terms
2 High potential for abuse Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.	2 High potential for abuse Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
Pregnancy Category
C Category C Risk cannot be ruled out See the full pregnancy warnings document.	C Category C Risk cannot be ruled out See the full pregnancy warnings document.
Drug Interactions
A total of 422 drugs are known to interact with Nucynta: 186 major drug interactions (794 brand and generic names) 235 moderate drug interactions (1177 brand and generic names) 1 minor drug interactions (3 brand and generic names)	A total of 422 drugs are known to interact with Nucynta ER: 186 major drug interactions (794 brand and generic names) 235 moderate drug interactions (1177 brand and generic names) 1 minor drug interactions (3 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Alcohol can increase the nervous system side effects of tapentadol such as dizziness, drowsiness... View more	Alcohol can increase the nervous system side effects of tapentadol such as dizziness, drowsiness... View more
Disease Interactions
Impaired GI motility Infectious diarrhea Prematurity Acute alcohol intoxication Drug dependence Hypotension Intracranial pressure Respiratory depression Gastrointestinal obstruction Liver disease Renal dysfunction Seizure disorders Urinary retention Biliary tract disease	Impaired GI motility Infectious diarrhea Prematurity Acute alcohol intoxication Drug dependence Hypotension Intracranial pressure Respiratory depression Gastrointestinal obstruction Liver disease Renal dysfunction Seizure disorders Urinary retention Biliary tract disease
First Approval Date
November 20, 2008	August 25, 2011
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group En español	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group En español
Patient Resources
Nucynta uses	Nucynta ER uses Advanced reading
Professional Resources
Prescribing information	Prescribing information
Related Treatment Guide
Pain	Diabetic Peripheral Neuropathy Pain

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Nucynta vs Nucynta ER

See also:

Paracetamol

Tylenol

Dupixent

Naproxen

Oxycodone

Cyclobenzaprine

Hydroxyzine

Meloxicam

Tramadol

Ibuprofen

Further information

Comparing Nucynta vs Nucynta ER

See also:

Further information

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