Comparing Norethindrone vs Skyla

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
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Norethindrone

Skyla levonorgestrel

Prescribed for Abnormal Uterine Bleeding, Endometriosis, Amenorrhea, Birth Control. norethindrone may also be used for purposes not listed in this medication guide.

Prescribed for Birth Control. Skyla may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

View all 1245 reviews

View all 1500 reviews

Drug Class

Side Effects

Commonly reported side effects include: ectopic pregnancy.

See the full norethindrone side effects document.

Common side effects include: amenorrhea.

See the full Skyla side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	50 tablet
Dosage	5 mg
Per Unit^*	$0.98
Cost^*	$49.23

View all norethindrone prices

Quantity	1 device
Dosage	13.5 mg
Per Unit^*	$878.18
Cost^*	$878.18

View all Skyla prices and generic prices

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Generic Availability

Yes (this medicine)

Yes

Dosage Form(s) Available

Oral tablet

Intrauterine device

Brand Names

Aygestin, Camila, Deblitane, Errin, Heather, Incassia, Jencycla, Jolivette, Lyleq, Lyza, Nora-Be, Norlyda, Norlyroc, Ortho Micronor, Sharobel, Tulana View more Other levonorgestrel brands include: Aftera, AfterPill, AfterPlan, Athentia Next, BionaFem, EContra EZ, EContra One-Step, Fallback Solo, Kyleena, Liletta, Mirena, Morning After, My Choice, My Way, New Day, Next Choice One Dose, Opcicon One-Step, Option 2, Plan B One-Step, PostDay One-Step, Preventeza, React, Take Action View more

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

10 hours

45 hours

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

Category X Not for use in pregnancy

See the full Pregnancy Warnings document.

FDA Alerts

N/A

Drug Interactions

A total of 220 drugs are known to interact with norethindrone:

31 major drug interactions (87 brand and generic names)
178 moderate drug interactions (562 brand and generic names)
11 minor drug interactions (31 brand and generic names)

A total of 214 drugs are known to interact with Skyla:

31 major drug interactions (87 brand and generic names)
171 moderate drug interactions (541 brand and generic names)
12 minor drug interactions (33 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You... View more

Grapefruit juice may increase the blood levels of certain medications such as levonorgestrel. You... View more

Disease Interactions

First Approval Date

April 21, 1982

N/A

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer