Comparing Nitrofurantoin vs Trimethoprim
| Nitrofurantoin | Trimethoprim |
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| Nitrofurantoin | Trimethoprim |
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Prescription only
Nitrofurantoin is an effective antibiotic with a low risk of inducing bacterial resistance that is used specifically to treat urinary tract infections caused by susceptible bacteria. Long-term use... View more |
Prescription only
Prescribed for Urinary Tract Infection, Prevention of Bladder infection, Pneumocystis Pneumonia, Bladder Infection, Middle Ear Infections. Trimethoprim may also be used for purposes not listed in... View more |
Related suggestions Urinary Tract Infection
Bladder Infection
Prevention of Bladder infection (Cystitis Prophylaxis)
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| More about Nitrofurantoin | More about Trimethoprim | ||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Nitrofurantoin has an average rating of 4.5 out of 10 from a total of 1880 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 52% reported a negative effect. |
Trimethoprim has an average rating of 3.1 out of 10 from a total of 196 ratings on Drugs.com. 13% of reviewers reported a positive effect, while 70% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||||||||||
View all Nitrofurantoin side effects |
View all Trimethoprim side effects |
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| Drug Class | |||||||||||||||||
| Generic Availability | |||||||||||||||||
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Lower cost generic |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all Nitrofurantoin prices |
View all Trimethoprim prices |
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| Dosage Forms | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Furadantin, Macrobid, Macrodantin | Primsol | ||||||||||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||||||||||
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1 hour |
14 hours |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 222 drugs are known to interact with Nitrofurantoin:
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A total of 159 drugs are known to interact with Trimethoprim:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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February 06, 1953 |
May 30, 1980 |
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| WADA Class View classifications | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient Resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.