Comparing Nitrofurantoin vs Trimethoprim
| Nitrofurantoin | Trimethoprim |
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| Nitrofurantoin | Trimethoprim |
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Prescription only
Nitrofurantoin is an effective antibiotic with a low risk of inducing bacterial resistance that is used specifically to treat urinary tract infections caused by susceptible bacteria. Long-term use... View more |
Prescription only
Prescribed for Urinary Tract Infection, Bladder Infection, Prevention of Bladder infection, Otitis Media, Pneumocystis Pneumonia. trimethoprim may also be used for purposes not listed in this medication guide. View more |
Related suggestions Urinary Tract Infection
Bladder Infection
Prevention of Bladder infection (Cystitis Prophylaxis)
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| More about Nitrofurantoin | More about Trimethoprim | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Nitrofurantoin has an average rating of 4.3 out of 10 from a total of 1821 ratings on Drugs.com. 29% of reviewers reported a positive effect, while 54% reported a negative effect. |
Trimethoprim has an average rating of 2.8 out of 10 from a total of 187 ratings on Drugs.com. 11% of reviewers reported a positive effect, while 74% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: nitrofurantoin side effects in more detail. |
See also: trimethoprim side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all nitrofurantoin prices |
View all trimethoprim prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Furadantin, Macrobid, Macrodantin | Primsol | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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1 hour |
14 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 183 drugs are known to interact with nitrofurantoin:
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A total of 129 drugs are known to interact with trimethoprim:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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February 06, 1953 |
May 30, 1980 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.