Trimethoprim Dosage

Usual Adult Dose for Urinary Tract Infection

Recommended dose:
100 mg orally every 12 hours for 10 days or 200 mg orally every 24 hours for 10 days

Comments:
-Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to this drug.
-Therapy may be initiated prior to obtaining the results of susceptibility tests.

Use: For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus

Usual Pediatric Dose for Urinary Tract Infection

12 TO 18 YEARS OF AGE:
Recommended dose:
100 mg orally every 12 hours for 10 days or 200 mg orally every 24 hours for 10 days

Comments:
-Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to this drug.
-Therapy may be initiated prior to obtaining the results of susceptibility tests.

Use: For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus

Usual Pediatric Dose for Otitis Media

Acute infections:
6 months or older: 5 mg/kg orally every 12 hours for 10 days

Use: For the treatment of acute otitis media due to susceptible strains of Streptococcus pneumoniae and Haemophilus influenzae

Renal Dose Adjustments

Severe renal dysfunction (CrCl 15 to lea than 30 mL/min): Usual dose should be reduced by 50%
End-stage renal disease (CrCl less than 15 mL/min): Use is not recommended

Liver Dose Adjustments

Caution recommended.

Precautions

-Safety and effectiveness in pediatric patients below the age of 2 months have not been established.
-Safety and effectiveness of this drug as a single agent has not been established in pediatric patients under 12 years of age.
-Safety and effectiveness for the treatment of acute otitis media has not been established in patients below the age of 6 months.

Consult WARNINGS section for additional precautions.

Dialysis

Peritoneal dialysis is not effective and hemodialysis only moderately effective in eliminating this drug.

Other Comments

Administration advice:
-This drug may be taken with food to minimize the possibility of GI disturbance.
-To ensure maximal urinary concentrations it may be advantageous to take the dose before bedtime.

General:
-To reduce the development of drug-resistant bacteria and maintain the effectiveness of this drug and other antibacterial drugs, it should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.
-Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to this drug. Therapy may be initiated prior to obtaining the results of these tests.

Patient advice:
-Patients should be counseled that antibacterial drugs should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold).
-Patients should be counseled to take the medication exactly as directed. Skipping doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that bacteria will develop resistance.