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User Reviews for Trimethoprim

Also known as: Primsol

Trimethoprim has an average rating of 3.2 out of 10 from a total of 110 ratings on Drugs.com. 13% of those users who reviewed Trimethoprim reported a positive effect, while 68% reported a negative effect.

Condition Avg. Rating Reviews Compare
Urinary Tract Infection  
3.2
87 reviews 189 medications
Bladder Infection  
3.7
20 reviews 82 medications
Prevention of Bladder infection  
1.7
3 reviews 29 medications
Summary of Trimethoprim reviews 3.2 110 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Trimethoprim

Bluerain33 · Taken for less than 1 month June 6, 2021

For Urinary Tract Infection: “Was given a 3 day course 200mg tablets for a bladder infection and I was dubious in taking them and now I know why. I took my first one yesterday evening and my side effect symptoms began with itchy skin, blurred vision and the start of a headache. I went to bed early because I felt weak then kept waking in the night and each time my mouth was extremely dry. I woke with a bad headache today and will not be taking anymore of that antibiotic. I think we are all just lab rats”

1 / 10
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Liz1960 May 26, 2021

For Urinary Tract Infection: “Day 3 and this drug has made absolutely no difference at all. I recall this exact same thing happening last time I had a UTI (a while ago now) and I was changed to a different antibiotic. My experience has not been a good one at all.”

1 / 10
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Jenbob · Taken for less than 1 month May 12, 2021

For Urinary Tract Infection: “I have always found almost immediate relief in my symptoms with this drug and zero side effects. I’m extremely thankful that it works for me, it’s been a life saver.”

10 / 10
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Frequently asked questions

Stardust · Taken for less than 1 month November 30, 2020

For Urinary Tract Infection: “First of all I have had a stressful time recently but was coming out of it. Suspected UTI so GP prescribed 7 days worth of Trimethoprim. After 2 doses the panic started. Thought nothing of it. Day 2 by the evening I thought I had flu. Body aches, headache, hot flashes alternating with shivering then every pulse in my body was thumping as well as my heart so that then lead to a panic attack as my pulse was going way too fast. I feel awful today. General weakness and body aches and my head is thumping. I actually feel like stopping these tonight after 3 days as I feel awful, anxious and tonight depressed and hopeless. Yes the burning when peeing has stopped but now I'm peeing loads because of the anxiety and panic. Honestly can't 100% say Trimethoprim has caused all of it but I'm pretty sure it's caused a lot of it. Just putting this here in case anyone else is suffering the same you aren't alone. I see others have suffered similar.”

3 / 10
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MARSE86 · Taken for less than 1 month April 27, 2021

For Urinary Tract Infection: “Got prescribed a 7 day course of Trimethoprim 200mg twice daily after symptoms returned after course of Nitrofurantoin. Started it in the evening after a meal and immediately felt very tired (figured could be UTI) Continued with course till day 3, getting progressively more tired, could not stay awake. Felt very weak and shaky and had a stiff neck. Had nausea but continued to eat. When I was awake I had a sense of anxiety, clenching fists, raised shoulders up to neck, palpitations, clenched jaw. Not usually something I struggle with. General feeling of being very unwell. Strange sharp aches and pains randomly on my body, abdomen and back, inner thighs etc. Very thirsty as well, waking to drink but not to pee. Decided to stop the antibiotic and felt better the next day, 24 hours after last med was taken. Would never touch this again.”

1 / 10
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S · Taken for less than 1 month March 5, 2021

For Urinary Tract Infection: “Presented to Doctors for UTI. Was prescribed trimethoprim for 5 days. 300mg, one per day. I have never had such a horrible reaction to an antibiotic. I did think it was odd that the dose was so low and only 1 per day, and now I know why. Any higher and I probably would have been hospitalised! I had the worst, worst stomach cramps, nausea, wobbly legs, zero energy, couldn’t sleep at night, sweating on and off, horrible jaw clenching, tense body muscles (especially in the back of my neck) and very, very anxious. It’s easy to second guess yourself and think that these side affects are just in conjunction with the UTI but me, personally, know my body very, very well and these tablets just made me so sick and in my opinion the UTI was easier than taking these. Now that I’m 2 days off these pills I am creeping back to normality. My advice is don’t take them unless you want to risk the side affects.”

1 / 10
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AMA · Taken for less than 1 month February 3, 2020

For Urinary Tract Infection: “I was prescribed Trimethoprim three days ago after a being taken off nitrofurantoin due to adverse reaction. I am coping but the fatigue and nausea are the worst side effects of this drug to me. I have to take these for the next for days and and just hoping they do their job and I can get on with my life. Currently feel exhausted, nauseous, no appetite and just generally grotty. Loth to go back to GP complaining as the last thing I want is yet another antibiotic prescribing with even worse side effects. Hugs to anyone taking UTI antibiotics as they all seem to come with a lovely list of side effects.”

6 / 10
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More FAQ

Enigma · Taken for less than 1 month April 24, 2021

For Urinary Tract Infection: “GP put me on Trimethoprim 300 twice daily for UTI caused by enlarged prostate and a huge bladder stone. Had the first dose on the day one. Day two took second dose, symptoms seemed to be elevating, by the third dose started to feel strange in my thoughts, I knew something wasn't right but didn't think of antibiotic. Started getting dizzy like car sickness, trembling everywhere in my body then suddenly threw up anywhere and everywhere, caused many physical symptoms as well as anxiety, depression, dissasociation and suicidal thoughts. Long story short attempted suicide, police were called, been admitted to hospital three times for physical and mental assessment. Please accept my best wishes if you have used this medicine with adverse effects, I wish you a speedy recovery.”

1 / 10
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Lynda w · Taken for less than 1 month November 14, 2020

For Urinary Tract Infection: “I got this antibitic trimethoprim and have been taking it for two days, but have stopped taking it now. I thought I was seriously ill till reading these reviews. The side effects symptoms it caused was constant nausea, blinding headaches, flashes all wrapped up in excessive anxiety. NEVER AGAIN!!”

1 / 10
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Lilou · Taken for less than 1 month February 27, 2020

For Urinary Tract Infection: “I was prescribed 5 day course of 300mg trimethoprim for UTI treatment when I walked in at Emergencies (there was blood and total incontinence). Have had the worst days ever: insomnia, massive throbbing headaches, my hands are shaking, and bloating on the face and legs. Feel so tired, depressed and I've been having obsessive-catastrophic thoughts. Is it just me? The blister contains 7 pills, unsure whether to finish or stop at 5, as I don't want the UTI back.”

6 / 10
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Michelle · Taken for less than 1 month September 5, 2020

For Urinary Tract Infection: “I was on trimethoprim for 7 days taking 1 pill twice a day. From about day 2-3 I was getting nauseous and headaches and felt very ill. I could not go to the toilet and by the morning of day 4 I felt extremely weak and nauseous . However I was able to go to the toilet from day 4 but I had the shakes and was weak. Each night after my second tablet around 6pm I got pain and spasms where my kidney is. Not sure if this is working”

6 / 10
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Char · Taken for less than 1 month February 1, 2019

For Urinary Tract Infection: “Got diagnosed with a urine infection and for prescribed Trimethoprim for 3 days, twice a day. The bladder infection stopped after 2/3 antibiotics. Finished the course now and completely back to normal. Didn’t get any serious side effects other than a slight headache on the second day, but didn’t get anything like nausea/anxiety. Overall pleased with the antibiotic and feeling much better now because of it.”

10 / 10
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KG · Taken for 1 to 2 years November 9, 2020

For Urinary Tract Infection: “I've taken Alprim previously in a small course, but was put on a 7 day course and it has taken the life out of me, I don't want to eat, the thought of it makes my stomach turn, feel like vomiting every second, tired, sweating, anxiety.”

2 / 10
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Shelby1 December 7, 2020

For Urinary Tract Infection: “This trimethoprim medication is dreadful, the side effects seem to hang on well after finishing the course. I’ve used this medication a few times, and thought it was only me with side effects. I have a thyroid disorder and this medication has absolutely sent my blood reading all over the place ... which results in my thyroid medication being lowered each time .. Terrible insomnia, my body ached all over, and itchy...these side effects still linger, two months later ...it’s literally destroyed my gut and wrecked my insides ..all I’m doing now is working on trying to rectify this ..”

1 / 10
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ChrisM October 21, 2020

For Urinary Tract Infection: “First 7 days of taking Trimethoprim made me feel ill, nauseous, vomiting, shaking, sweats, headache felt better once course ended but 2 weeks later UTI back further 7 days prescribed this time raging temperature, vomiting, mouth sore, throat sore, runny nose and breathless shaking clammy skin rash. Urine test showed clear of UTI told by GP immediately stop taking Trimethoprim 24 hours later still feeling ill with intermittent above side effects wondering how long it will take to leave my system”

1 / 10
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Belle · Taken for less than 1 month May 29, 2020

For Urinary Tract Infection: “There are better antibiotics with less severe side effects than trimethoprim. I take medication regularly which I've not had side effects for however alprim gave me a headache that got more severe til I was throwing up in my car leaving work and ever so nauseous. The pain was so severe in the temples of my head and cramping all through the base my neck. I couldn't move nor ease it. My jaws were clenched so much I had to put my tongue in between my teeth to alleviate this cramping sensation. Threw up all night til bile was all there was left. I was scared and anxious, no energy.”

1 / 10
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Never again ... ! · Taken for less than 1 month February 23, 2021

For Urinary Tract Infection: “UTI ... so I was given trimethoprim, two a day, seven days. Things seemed fine until 7th day. Rash broke out all over my body. Felt like I had a fever, though I had normal temperature. But when I tried to sleep .... ! Sweating, constant shifting position, none of which were comfortable for more than 10 seconds. My mind seemed to be racing away on its own, and I had no idea why I was running over and over in my head all this stuff that was absolutely nothing to do with me. But every time I even tried to nap or doze, away went my mind at breakneck speed on weird subjects. For two nights I simply did not sleep at all, had to sit on the sofa just waiting for morning. It was very scary. Never again would I take this.”

3 / 10
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disappointed lol · Taken for less than 1 month November 11, 2020

For Urinary Tract Infection: “I went into emergency for lower back pain last week, told me I had UTI. The hospital prescribed me trimethoprim for 3 day but my GP increased it to 7 days. I'm on my 5th day (I stopped) and it has been HORRIBLE. The sided effects from trimethoprim are nausea, body aches, diarrhea, runny nose, high anxiety EVERYTHING that has been described on this thread. I thought it was just me until I found this forum. I will be seeing my GP tomorrow. I can't deal with these sides effects. Never again am I touching these antibiotics ...”

1 / 10
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Sabrina · Taken for less than 1 month June 25, 2020

For Urinary Tract Infection: “Im looking on here in the hopes I hear of others experience with almost a numbness in my right hand ..( weird trying to text ect..) I don't know how to describe it - like its a bit asleep and shakes if I try use the fingers individually . If I put both hands on table flat and raise each finger, left hand is steady ,but right hand fingers shaking. I am on meds 3 days now. I am not going to take them today. I have only noticed this side effect from yesterday and am hoping its the medication ,trying not to go to a dark place that it could be a bigger issue.”

1 / 10
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Bad day November 9, 2019

For Urinary Tract Infection: “I’m on day 6 of this medication trimethoprim for a UTI and I can’t wait to get off it. I am waking up all night long, headaches, trembling fingers, aching bones it seems to be interacting with my blood pressure tablets and it’s making me feel on edge. The first day was ok, the second day started having these side effects and as each day passes, I am literally getting worse. In order to take this last tablet tomorrow I have had to stop my blood pressure tablets. My dosage is 300 mg per day. The UTI seems to have gone, but I want to finish the course, scared incase it comes back, I'll have to find some other antibiotic, can’t tolerate this any longer.”

3 / 10
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Susie · Taken for less than 1 month November 2, 2020

For Urinary Tract Infection: “On this trimethoprim medication for 3 days for UTI and OMG the side effects are horrendous. How can they give out medication to people that is suppose to make you well but ends up a total nightmare. I couldn't sleep due to burning up and feeling really nauseous all night. No appetite, feeling weak, dry mouth, headache, anxiety, painful back. Have stopped taking them as there are a lot better medications out there. I think doctors should really read up about some of the stuff they hand out so easily to people. Hoping these horrible feelings pass soon.”

1 / 10
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Fenny · Taken for less than 1 month December 8, 2020

For Urinary Tract Infection: “I took trimethoprim for 4 days before switching to a better antibiotic as trimethoprim didn't clear my UTI. While on it I would wake up during the nights with terrible anxiety and couldn't get back to sleep. As soon as I switched to another medication the sleeping/anxiety issues disappeared.”

1 / 10
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Jess · Taken for less than 1 month October 27, 2019

For Urinary Tract Infection: “Was prescribed 7 days (one a day) script of alprim. 300mg of trimethoprim in it. I got onto my urinary tract infection early so the drug worked wonders within 24 hours but by the third day my anxiety was extremely heightened and I was having panic attacks and usually my anxiety never does that. I couldn’t figure out why I was so on edge, then I realised this script was the only new thing. I have two more days to go and I cannot wait to get off the stuff I feel so anxious and like I’m gonna cry at the drop of a hat.”

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JettaJB · Taken for less than 1 month March 20, 2020

For Urinary Tract Infection: “This antibiotics trimethoprim is good for treating UTI’s but give awful side effects Had 3 days worth of these and although cleared up infection came with some unwanted feelings worse side effects were migraine type headaches fatigue shakes nausea and racing heart Absolutely awful wouldn’t want to take these again thank god it was only 3 days!”

3 / 10
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Florana · Taken for less than 1 month September 21, 2020

For Urinary Tract Infection: “Had trimethoprim for a UTI, one a day. The first night I had the most horrible acid reflux all night, woke up the next morning with the sorest throat in the world and about 2 hours sleep. Then after night 2, I experienced a massive headache where I couldn't put my headset on to work and I felt so tired. By night 3 I was a bit itchy on my arms and a rash developed but the UTI had gone by then, so I stopped treatment. If a Dr recommends alprim again I'm going to say no.”

6 / 10
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Pooh Bear · Taken for less than 1 month August 11, 2019

For Urinary Tract Infection: “Was prescribed trimethoprim(in UK) 2x200mg for a UTI, within an hour of taking first one, I was suffering from a killer headache, light headedness, nausea and heart palpitations. Wore off after 4 hours, after taking second tablet, I actually passed out! Same symptoms, only multiplied by 10. Had used these tablets before with no side effects and actually wondered it it was more than a UTI. Had restless night, unable to sleep, itchy skin, felt as if there was something crawling underneath my skin. Took third tablet in the morning and oh my god, I was unable to speak, could hardly walk wasn't able to eat, couldn't pee, and my heart was racing. I will never take these tablets again, and strongly advise anyone else to do the same.”

1 / 10
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A · Taken for less than 1 month May 1, 2020

For Urinary Tract Infection: “I'm on day 3 of this medication and before reading these reviews I have had a migraine that won't go away, shaky hands, trembling, paranoid, dry mouth, nausea and the itchiest skin. These are all of the symptoms I've read of people that have taken this it's actually scary worth reading up before you take something new.”

1 / 10
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Alarming December 11, 2020

For Bladder Infection: “I wish I had seen these comments before I took Trimethoprim, which was several years ago now. It affected me really quickly too and within about an hour I also experienced negative effects from this drug. Never again! High anxiety and random thoughts. Had to keep the light on all night as I was so afraid. Extremely fatigued, and depressed too. Senses heightened greatly and at times had sudden surges of energy doing bizarre things. Thought I was having some sort of a breakdown. Took it for a few days and then stopped. It left me feeling awful for several days. Put on another drug which worked well on the infection without such negative side effects.”

1 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.