Comparing Mercaptopurine vs Methotrexate

For Crohn's Disease, Maintenance I've been on this medicine for 2 months. I feel, most days like I've been in a car accident. The pain is very difficult to handle. I ache like I have the flu. Thinking about not taking good it and take my chances. What could be worse?

For Crohn's Disease, Maintenance I've been using this drug for just over a month and everything seems like it's going down hill. This drug will make me extremely tired but also keep me awake. It's too inconsistent for my body. It should be helping with bodily functions and minimize pain but it does quite the opposite. Some days my body can't move very fast because of the pain. And if it's not the pain it's fatigue all day. I've had the same problem with other drugs like this. There has to be a way to help without all of the drugs or surgeries.

For Rheumatoid Arthritis I am 62, and was diagnosed with RA about 10 years ago, I have been through a battery of drugs to suppress my immune system, ending up on subcutaneous methrotrexate 10mg, I originally had a 'bad day' the day after my injections, however it seems to be getting to be a bad couple of days lately. Intense pressure head ache (I'm also a migraine sufferer), nausea, confusion, tiredness and now really troubled sleep, nightmares, and some visual disruption/ (almost hallucinations), feelings of panic, unease and claustrophobic. I know the alternatives, stop and face RA full on, but I would rather get 3/4 good days than be on the road to being completely disabled.

For Rheumatoid Arthritis Been taking Methotrexate for almost 3 years now. Last fall, I felt good enough that I went off it without my Drs knowledge, because it made me feel pretty ill for a day or so after. What a mistake! I started taking it again about 2 months ago, and although it still makes me sick, it sure beats the pain I`m in without it. (on 25 mg a week, along with Hydroxychloroquin and folic acid)