Comparing Mercaptopurine vs Methotrexate
| Mercaptopurine | Methotrexate |
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| Mercaptopurine | Methotrexate |
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Prescription only
Prescribed for Acute Lymphoblastic Leukemia. May also be prescribed off label for Crohn's Disease - Maintenance, Autoimmune Hepatitis, Crohn's Disease - Acute, Inflammatory Bowel Disease, Intestinal... View more |
Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Related suggestions |
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| More about Mercaptopurine | More about Methotrexate | ||||||||||||||||
| Generic Status | |||||||||||||||||
| Ratings & Reviews | |||||||||||||||||
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Mercaptopurine has an average rating of 6.1 out of 10 from a total of 30 ratings on Drugs.com. 47% of reviewers reported a positive effect, while 33% reported a negative effect. |
Methotrexate has an average rating of 6.6 out of 10 from a total of 277 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 24% reported a negative effect. |
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| Drug Class | |||||||||||||||||
| Side Effects | |||||||||||||||||
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See also: mercaptopurine side effects in more detail. |
Commonly reported side effects include:
See also: methotrexate side effects in more detail. |
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| Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all mercaptopurine prices |
View all methotrexate prices |
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| Dosage Form(s) Available | |||||||||||||||||
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| Brand Names | |||||||||||||||||
| Purinethol, Purixan | Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | ||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
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2 hours |
15 hours |
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| CSA Schedule ** View glossary of terms | |||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | |||||||||||||||||
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Category D
Positive evidence of risk
See the full pregnancy warnings document. |
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||||||||||
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A total of 250 drugs are known to interact with mercaptopurine:
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A total of 644 drugs are known to interact with methotrexate:
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| Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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| Disease Interactions | |||||||||||||||||
| First Approval Date | |||||||||||||||||
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September 11, 1953 |
December 07, 1953 |
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| WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
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N/A |
N/A |
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| More Information | |||||||||||||||||
| Patient resources | |||||||||||||||||
| Professional Resources | |||||||||||||||||
| Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.