Comparing Low-Ogestrel-28 vs Norethindrone

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Low-Ogestrel-28 (ethinyl estradiol / norgestrel)	Norethindrone	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Low-Ogestrel-28 (ethinyl estradiol / norgestrel)	Norethindrone	Enter another drug to compare
Prescription only Prescribed for Abnormal Uterine Bleeding, Birth Control, Endometriosis, Gonadotropin Inhibition. Low-Ogestrel-28 may also be used for purposes not listed in this medication guide.	Prescription only Prescribed for Abnormal Uterine Bleeding, Endometriosis, Amenorrhea, Gender Affirming Hormone Therapy, Birth Control. Norethindrone may also be used for purposes not listed in this medication guide.	Related suggestions Birth Control Mirena Nexplanon Lo Loestrin Fe Depo Provera NuvaRing Sprintec Abnormal Uterine Bleeding Medroxyprogesterone Provera Megestrol Sprintec Premarin Ethinyl estradiol / levonorgestrel Endometriosis Lupron Depot Orilissa Progesterone Medroxyprogesterone Zoladex Provera
More about Low-Ogestrel-28 (ethinyl estradiol / norgestrel)	More about Norethindrone
Ratings & Reviews
Low-Ogestrel-28 has an average rating of 6.6 out of 10 from a total of 68 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 24% reported a negative effect.	Norethindrone has an average rating of 4.9 out of 10 from a total of 1579 ratings on Drugs.com. 33% of reviewers reported a positive effect, while 44% reported a negative effect.
View all 68 reviews	View all 1579 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Nausea (20.6%) Weight gain (20.6%) Acne (19.1%) Cramps (17.6%) Mood swings (17.6%) Anxiety (11.8%) Sexual dysfunction (10.3%) View all Low-Ogestrel-28 side effects	Bleeding (22.2%) Weight gain (18.4%) Acne (18.2%) Cramps (18.2%) Mood swings (14.8%) Spotting (11.7%) Sore breasts (11.3%) View all Norethindrone side effects
Drug Class
Contraceptives	Contraceptives Progestogens
Generic Availability
Lower cost generic approved	Lower cost generic
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
Oral tablet	Oral tablet
Brand Names
Other ethinyl estradiol / norgestrel brands include: Cryselle, Elinest, Ogestrel 0.5/50, Turqoz	Affodel, Camila, Deblitane, Emzahh, Errin, Gallifrey, Heather, Incassia, Jencycla, Lyleq, Lyza, Meleya, Nor-QD, Norlyda, Norlyroc, Orquidea, Sharobel, Tulana View more
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
N/A	10 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
X Category X Not for use in pregnancy See the full pregnancy warnings document.	X Category X Not for use in pregnancy See the full pregnancy warnings document.
Drug Interactions
A total of 502 drugs are known to interact with Low-Ogestrel-28: 78 major drug interactions (202 brand and generic names) 374 moderate drug interactions (1397 brand and generic names) 50 minor drug interactions (620 brand and generic names)	A total of 268 drugs are known to interact with Norethindrone: 61 major drug interactions (165 brand and generic names) 193 moderate drug interactions (657 brand and generic names) 14 minor drug interactions (156 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Grapefruit juice may increase the blood levels of certain medications such as norgestrel. You may... View more	Grapefruit juice may increase the blood levels of certain medications such as norethindrone. You... View more
Disease Interactions
Smoking Abnormal vaginal bleeding Carcinomas (estrogenic) Hypercalcemia in breast cancer Hypertension Thromboembolism/cardiovascular Hepatic neoplasms Breast malignancy Liver disease Thromboembolism Angioedema Gallbladder disease Hypercalcemia Hyperlipidemia Liver disease Melasma Depression Fluid retention Glucose intolerance Retinal thrombosis Thyroid function tests Hyperlipidemia Weight gain	Abnormal genital bleeding Hepatic neoplasms Breast malignancy Liver disease Thromboembolism Depression Fluid retention Glucose intolerance Retinal thrombosis Thyroid function tests Hyperlipidemia Weight gain
First Approval Date
N/A	April 21, 1982
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Drug images	Side effects Drug interactions Dosage Pricing and coupons Pregnancy warnings Breastfeeding warnings Drug images Support group
Patient Resources
Low-Ogestrel-28 uses Advanced reading	Norethindrone uses
Professional Resources
Prescribing information	Monograph (AHFS) Prescribing information
Related Treatment Guide
Abnormal Uterine Bleeding Birth Control Endometriosis Gonadotropin Inhibition	Abnormal Uterine Bleeding Endometriosis Amenorrhea Gender Affirming Hormone Therapy Birth Control

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Low-Ogestrel-28 vs Norethindrone

See also:

Provera

Slynd

Wegovy

Yaz

Depo Provera

Nexplanon

Sprintec

Mirena

Lo Loestrin Fe

Levonorgestrel

Further information