Comparing Letrozole vs Tamoxifen
| Letrozole Remove Letrozole from your drug comparison | Tamoxifen Remove Tamoxifen from your drug comparison |
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| Letrozole Remove Letrozole from your drug comparison | Tamoxifen Remove Tamoxifen from your drug comparison | ||||||||||||||||
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Prescribed for Breast Cancer - Adjuvant, Breast Cancer - Metastatic, Breast Cancer. May also be prescribed off label for Female Infertility. |
Prescribed for Breast Cancer - Adjuvant, Breast Cancer - Metastatic, Breast Cancer - Male, Breast Cancer, Breast Cancer - Palliative, McCune-Albright Syndrome, Precocious Puberty. May also be... View more |
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Prescription only |
Prescription only |
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Ratings & Reviews |
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Drug Class |
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Side Effects |
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Commonly reported side effects include: bone fracture, arthralgia, edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and flushing. See the full letrozole side effects document. |
Commonly reported side effects include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. See the full tamoxifen side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all letrozole prices |
View all tamoxifen prices |
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Generic Availability |
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Yes (this medicine) |
Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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| Femara | Soltamox | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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48 hours |
231 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category D
Positive evidence of risk
See the full Pregnancy Warnings document. |
Category D
Positive evidence of risk
See the full Pregnancy Warnings document. |
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Drug Interactions |
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A total of 91 drugs are known to interact with letrozole:
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A total of 383 drugs are known to interact with tamoxifen:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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July 25, 1997 |
December 30, 1977 |
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WADA ClassView World Anti-Doping Agency classifications. |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.