S4. Hormone And Metabolic Modulators

Prohibited substances in classes S4.1 and S4.2 are Specified Substances. Those in classes S4.3 and S4.4 are non-Specified Substances.

The following hormone and metabolic modulators are prohibited.

S4.1. Aromatase Inhibitors

Including, but not limited to:

• 2-Androstenol  (5α-androst-2-en-17-ol)
• 2-Androstenone (5α-androst-2-en-17-one)
• 3-Androstenol  (5α-androst-3-en-17-ol)
• 3-Androstenone (5α-androst-3-en-17-one)
• 4-Androstene-3,6,17 trione (6-oxo)
• Aminoglutethimide
• Anastrozole
• Androsta-1,4,6-triene-3,17-dione (androstatrienedione)
• Androsta-3,5-diene-7,17-dione (arimistane)
• Exemestane
• Formestane
• Letrozole
• Testolactone

S4.2. Anti-estrogenic Substances [anti-estrogens And Selective Estrogen Receptor Modulators (serms)]

Including, but not limited to:

• Bazedoxifene
• Clomifene
• Cyclofenil
• Elacestrant
• Fulvestrant
• Ospemifene
• Raloxifene
• Tamoxifen
• Toremifene

S4.3. Agents Preventing Activin Receptor Iib Activation

Including, but not limited to:

• Activin A-neutralizing antibodies
• Activin receptor IIB competitors such as: 
  • Decoy activin receptors (e.g. ACE-031)
• Anti-activin receptor IIB antibodies (e.g. bimagrumab)
• Myostatin inhibitors such as:
  • Agents reducing or ablating myostatin expression
  • Myostatin-binding proteins (e.g. follistatin, myostatin propeptide)
  • Myostatin- or precursor - neutralizing  antibodies (e.g. apitegromab, domagrozumab, landogrozumab, stamulumab)

S4.4. Metabolic Modulators

S4.4.1 

• Activators of the AMP-activated protein kinase (AMPK), e.g. AICAR, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c);
• Peroxisome proliferator-activated receptor delta (PPARδ) agonists, e.g. 2-(2-methyl- 4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy) acetic acid (GW1516, GW501516) and;
• Rev-erbɑ agonists, e.g. SR9009, SR9011

S4.4.2 INSULINS AND INSULIN-MIMETICS, e.g. S519, S597

S4.4.3 MELDONIUM

S4.4.4 TRIMETAZIDINE