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S4. Hormone and Metabolic Modulators

If a Substance or Method is not defined in this list, please verify with your Anti-Doping Organization.

Prohibited substances in classes S4.1 and S4.2 are Specified Substances. Those in classes S4.3 and S4.4 are non-Specified Substances.

The following hormone and metabolic modulators are prohibited:

1. Aromatase inhibitors

Including, but not limited to:

  • 2-androstenol (5α-androst-2-en-17-ol)
  • 2-androstenone (5α-androst-2-en-17-one)
  • 3-androstenol (5α-androst-3-en-17-ol)
  • 3-androstenone (5α-androst-3-en-17-one)
  • 4-androstene-3,6,17 trione (6-oxo)
  • Aminoglutethimide
  • Anastrozole
  • Androsta-1,4,6-triene-3,17-dione (androstatrienedione)
  • Androsta-3,5-diene-7,17-dione (arimistane)
  • Exemestane
  • Formestane
  • Letrozole
  • Testolactone

2. Anti-Estrogenic Substances [Anti-Estrogens and Selective Estrogen Receptor Modulators (SERMS)]

Including, but not limited to:

3. Agents preventing activin receptor IIB activation

Including, but not limited to:

  • Activin A-neutralizing antibodies
  • Activin receptor IIB competitors (e.g. decoy activin receptors (e.g. ACE-031))
  • Anti-activin receptor IIB antibodies (bimagrumab)
  • Myostatin inhibitors such as: myostatin-neutralizing antibodies (e.g. domagrozumab, landogrozumab, stamulumab), myostatin-binding proteins (e.g. follistatin, myostatin propeptide); agents reducing or ablating myostatin expression).

4. Metabolic modulators

  • Activators of the AMP-activated protein kinase (AMPK), eg. AICAR, SR9009; and peroxisome proliferator activated receptor delta (PPARδ) agonists, e.g. 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy) acetic acid (GW1516, GW501516)
  • Insulins and insulin-mimetics;
  • Meldonium
  • Trimetazidine

See also