S4. Hormone and Metabolic Modulators
If a Substance or Method is not defined in this list, please verify with your Anti-Doping Organization.
Prohibited substances in classes S4.1 and S4.2 are Specified Substances. Those in classes S4.3 and S4.4 are non-Specified Substances.
The following hormone and metabolic modulators are prohibited:
1. Aromatase inhibitors
Including, but not limited to:
- 2-androstenol (5α-androst-2-en-17-ol)
- 2-androstenone (5α-androst-2-en-17-one)
- 3-androstenol (5α-androst-3-en-17-ol)
- 3-androstenone (5α-androst-3-en-17-one)
- 4-androstene-3,6,17 trione (6-oxo)
- Aminoglutethimide
- Anastrozole
- Androsta-1,4,6-triene-3,17-dione (androstatrienedione)
- Androsta-3,5-diene-7,17-dione (arimistane)
- Exemestane
- Formestane
- Letrozole
- Testolactone
2. Anti-Estrogenic Substances [Anti-Estrogens and Selective Estrogen Receptor Modulators (SERMS)]
Including, but not limited to:
- Bazedoxifene
- Clomifene
- Cyclofenil
- Fulvestrant
- Ospemifene
- Raloxifene
- Tamoxifen
- Toremifene
3. Agents preventing activin receptor IIB activation
Including, but not limited to:
- Activin A-neutralizing antibodies
- Activin receptor IIB competitors (e.g. decoy activin receptors (e.g. ACE-031))
- Anti-activin receptor IIB antibodies (bimagrumab)
- Myostatin inhibitors such as: myostatin-neutralizing antibodies (e.g. domagrozumab, landogrozumab, stamulumab), myostatin-binding proteins (e.g. follistatin, myostatin propeptide); agents reducing or ablating myostatin expression).
4. Metabolic modulators
- Activators of the AMP-activated protein kinase (AMPK), eg. AICAR, SR9009; and peroxisome proliferator activated receptor delta (PPARδ) agonists, e.g. 2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy) acetic acid (GW1516, GW501516)
- Insulins and insulin-mimetics;
- Meldonium
- Trimetazidine