Ibrance Alternatives Compared
| Ibrance (palbociclib) | Enhertu (fam-trastuzumab deruxtecan) | Letrozole |
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| Ibrance (palbociclib) | Enhertu (fam-trastuzumab deruxtecan) | Letrozole |
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Prescription only
Ibrance is a CDK4/6 inhibitor that may be used to treat advanced or metastatic hormone-receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer in combination... View more |
Prescription only
Prescribed for Breast Cancer - Metastatic, Non Small Cell Lung Cancer, Solid Tumors, Breast Cancer, Gastric Cancer. Enhertu may also be used for purposes not listed in this medication guide. |
Prescription only
Letrozole (brand name Femara) is a treatment that may be used to reduce the risk of breast cancer recurrence in postmenopausal women and also to increase the chance of ovulation in women with... View more |
Related suggestions Breast Cancer
Breast Cancer, Metastatic
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| More about Ibrance (palbociclib) | More about Enhertu (fam-trastuzumab deruxtecan) | More about Letrozole | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Ibrance has an average rating of 6.8 out of 10 from a total of 84 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 29% reported a negative effect. |
Enhertu has an average rating of 8.0 out of 10 from a total of 24 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 5% reported a negative effect. |
Letrozole has an average rating of 6.6 out of 10 from a total of 363 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect. |
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| Side Effects | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Ibrance prices |
View all Enhertu prices |
View all Letrozole prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
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N/A |
N/A |
Femara | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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29 hours |
136.8 hours |
48 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category D
Positive evidence of risk
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 468 drugs are known to interact with Ibrance:
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A total of 170 drugs are known to interact with Enhertu:
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A total of 114 drugs are known to interact with Letrozole:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
| First Approval Date | ||||||||||||||||||||||||||
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February 03, 2015 |
N/A |
July 25, 1997 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
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| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.