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Ibrance Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Ibrance (palbociclib) Verzenio (abemaciclib) Trodelvy (sacituzumab govitecan)
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Ibrance (palbociclib) Verzenio (abemaciclib) Trodelvy (sacituzumab govitecan)
Prescription only

Ibrance is a CDK4/6 inhibitor that may be used to treat advanced or metastatic hormone-receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) breast cancer in combination... View more

Prescription only

Verzenio (abemaciclib) is a targeted treatment that helps to reduce the growth and spread of cancer cells in the body. It may be used to treat HR+ HER2-, node-positive, early breast cancer at high... View more

Prescription only

Prescribed for Breast Cancer. Trodelvy may also be used for purposes not listed in this medication guide.

More about Ibrance (palbociclib) More about Verzenio (abemaciclib) More about Trodelvy (sacituzumab govitecan)
Ratings & Reviews

Ibrance has an average rating of 6.8 out of 10 from a total of 85 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 29% reported a negative effect.

Verzenio has an average rating of 8.1 out of 10 from a total of 31 ratings on Drugs.com. 61% of reviewers reported a positive effect, while 3% reported a negative effect.

Trodelvy has an average rating of 6.8 out of 10 from a total of 4 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 25% reported a negative effect.

View all 85 reviews

View all 31 reviews

View all 4 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Ibrance side effects

View all Verzenio side effects

View all Trodelvy side effects
Drug Class
Generic Availability

No lower cost generic approved

No lower cost generic approved

N/A
Pricing and Coupons * Prices are without insurance
Quantity 21 capsule
Strength 75 mg
Per unit* $837.31
Cost* $17,583.51

View all Ibrance prices

Quantity 14 tablet
Strength 50 mg
Per unit* $312.01
Cost* $4,368.17

View all Verzenio prices

Quantity 1 powder for injection
Strength hziy 180 mg
Per unit* $2,692.94
Cost* $2,692.94

View all Trodelvy prices

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Dosage Forms
  • Oral capsule
  • Oral tablet
  • Oral tablet
  • Intravenous powder for injection
Brand Names

N/A

N/A

N/A
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

29 hours

24.8 hours

18 hours
CSA Schedule 1 View glossary of CSA terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.
Drug Interactions

A total of 485 drugs are known to interact with Ibrance:

  • 97 major drug interactions (284 brand and generic names)
  • 365 moderate drug interactions (1088 brand and generic names)
  • 23 minor drug interactions (52 brand and generic names)

A total of 353 drugs are known to interact with Verzenio:

  • 109 major drug interactions (314 brand and generic names)
  • 236 moderate drug interactions (693 brand and generic names)
  • 8 minor drug interactions (23 brand and generic names)

A total of 226 drugs are known to interact with Trodelvy:

  • 80 major drug interactions (215 brand and generic names)
  • 131 moderate drug interactions (382 brand and generic names)
  • 15 minor drug interactions (39 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Palbociclib oral capsules (Ibrance) should be taken with food to help with its absorption... View more
  • Grapefruit juice can increase the blood levels of abemaciclib. This may increase side effects such... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Disease Interactions
First Approval Date

February 03, 2015

September 28, 2017

N/A
WADA Class View classifications

N/A

N/A

N/A
More Information
Patient Resources
Professional Resources
Related Treatment Guide

1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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