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Ibrance Side Effects

Generic Name: palbociclib

Note: This page contains information about the side effects of palbociclib. Some of the dosage forms included on this document may not apply to the brand name Ibrance.

In Summary

Common side effects of Ibrance include: decreased neutrophils. Other side effects include: infection and pulmonary embolism. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to palbociclib: capsule oral, oral capsule

In addition to its needed effects, some unwanted effects may be caused by palbociclib (the active ingredient contained in Ibrance). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking palbociclib:

More common:
  • Black, tarry stools
  • body aches or pain
  • chills
  • cough
  • ear congestion
  • fever
  • headache
  • loss of voice
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling or inflammation of the mouth
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Less common:
  • Anxiety
  • bloody nose
  • chest pain
  • dizziness or lightheadedness
  • fainting
  • fast heartbeat
  • hoarseness
  • sudden shortness of breath or troubled breathing

Minor Side Effects

Some of the side effects that can occur with palbociclib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea
  • hair loss or thinning of the hair
  • lack or loss of strength
  • nausea
  • vomiting
Less common:
  • Burning, numbness, tingling, or painful sensation
  • decreased appetite
  • unsteadiness or awkwardness
  • weakness in the arms, legs, or feet

For Healthcare Professionals

Applies to palbociclib: oral capsule


Very common (10% or more): Decreased white blood cells (up to 95%), decreased neutrophils (up to 94%), decreased hemoglobin (up to 83%), decreased lymphocytes (up to 81%), neutropenia (up to 75%), decreased platelets (up to 61%), leukopenia (up to 43%), anemia (up to 35%), thrombocytopenia (up to 17%)
Frequency not reported: Febrile neutropenia[Ref]


Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)
Common (1% to 10%): Pulmonary embolism[Ref]


Very common (10% or more): Infections (up to 55%), fatigue (up to 41%), asthenia (up to 13%)[Ref]


Most common adverse reactions (10% or greater incidence): neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.[Ref]


Very common (10% or more): Stomatitis (up to 25%), nausea (up to 25%), diarrhea (up to 25%), vomiting (up to 15%)[Ref]


Very common (10% or more): Alopecia (up to 22%)[Ref]


Very common (10% or more): Decreased appetite (up to 16%)[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (up to 13%)[Ref]


1. "Product Information. Ibrance (palbociclib)." Pfizer U.S. Pharmaceuticals Group, New York, NY.

Not all side effects for Ibrance may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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