Ibrance Side Effects

Generic name: palbociclib

Medically reviewed by Philip Thornton, DipPharm. Last updated on Dec 13, 2021.

Note: This document contains side effect information about palbociclib. Some dosage forms listed on this page may not apply to the brand name Ibrance.

Applies to palbociclib: capsule oral, oral capsule, oral tablet.

Serious side effects of Ibrance

Along with its needed effects, palbociclib (the active ingredient contained in Ibrance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking palbociclib:

More common

Black, tarry stools
bleeding gums
blood in the urine or stools
chest pain
chills
cough
difficulty breathing
fever
hoarseness
loss of voice
lower back or side pain
nosebleeds
painful or difficult urination
pale skin
pinpoint red spots on the skin
sore throat
sores, ulcers, or white spots on the lips or in the mouth
swelling or inflammation of the mouth
swollen glands
trouble breathing
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness

Incidence not known

General feeling of discomfort or illness
redness, swelling, or pain of the skin
scaling of the skin on the hands and feet
thickening of bronchial secretions
tingling of the hands and feet
ulceration of the skin

Other side effects of Ibrance

Some side effects of palbociclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Blurred vision
decreased appetite
diarrhea
dry skin
hair loss or thinning of the hair
increased tearing
lack or loss of strength
loss of or change in taste
nausea
skin rash
vomiting

Less common

Dry eye

For Healthcare Professionals

Applies to palbociclib: oral capsule, oral tablet.

Hematologic

Very common (10% or more): Decreased white blood cells (95%), decreased neutrophils (94%), decreased hemoglobin (83%), decreased lymphocytes (81%), neutropenia (80%), decreased platelets (61%), leukopenia (39%), anemia (24%), thrombocytopenia (16%)

Frequency not reported: Febrile neutropenia^[Ref]

Respiratory

Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)

Common (1% to 10%): Pulmonary embolism, interstitial lung disease, pneumonitis^[Ref]

Other

Very common (10% or more): Fatigue (37%), asthenia (17%), pyrexia (12%)^[Ref]

General

Most common adverse reactions (10% or greater incidence): Neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.^[Ref]

Gastrointestinal

Very common (10% or more): Nausea (35%), stomatitis (30%), diarrhea (26%), vomiting (16%)^[Ref]

Dermatologic

Very common (10% or more): Alopecia (33%), rash (18%), dry skin (12%)^[Ref]

Metabolic

Very common (10% or more): Decreased appetite (16%)^[Ref]

Nervous system

Very common (10% or more): Peripheral neuropathy (13%), dysgeusia (10%)^[Ref]

Immunologic

Very common (10% or more): Infections (e.g., nasopharyngitis, upper respiratory tract infection, urinary tract infection, oral herpes, sinusitis, rhinitis, bronchitis, influenza, pneumonia, gastroenteritis, conjunctivitis, herpes zoster, pharyngitis, cellulitis, cystitis, lower respiratory tract infection, tooth infection, gingivitis, skin infection, gastroenteritis viral, respiratory tract infection, respiratory tract infection viral, folliculitis) (60%)^[Ref]