Verzenio Side Effects
Generic name: abemaciclib
Medically reviewed by Drugs.com. Last updated on Mar 2, 2021.
Note: This document contains side effect information about abemaciclib. Some of the dosage forms listed on this page may not apply to the brand name Verzenio.
For the Consumer
Applies to abemaciclib: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, abemaciclib (the active ingredient contained in Verzenio) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking abemaciclib:
- Black, tarry stools
- bleeding gums
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blood in the urine or stools
- chest pain
- decreased urination
- difficulty with breathing
- dry mouth
- increased heart rate
- irregular heartbeat
- lower back or side pain
- pain in the chest, groin, or legs, especially the calves
- painful or difficult urination
- pale skin
- pinpoint red spots on the skin
- rapid breathing
- rapid weight gain
- severe, sudden headache
- slurred speech
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- stomach pain
- sudden loss of coordination
- sudden, severe weakness or numbness in the arm or leg
- sunken eyes
- swollen glands
- tingling of the hands or feet
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- vision changes
- wrinkled skin
- Blurred vision
- clay-colored stools
- dark urine
- decreased appetite
- fast heartbeat
- general feeling of discomfort or illness
- itching or skin rash
- loss of appetite
- numbness or tingling in the face, arms, or legs
- rapid, shallow breathing
- severe headache
- stomach pain or tenderness
- swelling of the feet or lower legs
- thickening of bronchial secretions
- trouble speaking or walking
- yellow eyes or skin
Side effects not requiring immediate medical attention
Some side effects of abemaciclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Change in taste
- dry mouth
- loss of taste
- loss or thinning of the hair
- swelling or inflammation of the mouth
For Healthcare Professionals
Applies to abemaciclib: oral tablet
The most common adverse reactions reported (20% or greater incidence) were increased creatinine (98%), decreased white blood cell count (91%), diarrhea (90%), decreased neutrophil count (88%), anemia (84%), fatigue/asthenia (65%), nausea (64%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), decreased appetite (45%), infections (43%), increased ALT (41%), abdominal pain (39%), increased AST (37%), vomiting (35%), leukopenia (28%), and thrombocytopenia (20%).[Ref]
Very common (10% or more): Increased creatinine (98%)[Ref]
Very common (10% or more): Decreased white blood cell count (91%), decreased neutrophil count (88%), anemia (84%), decreased lymphocyte count (63%), decreased platelet count (53%), neutropenia (46%), leukopenia (28%), thrombocytopenia (20%)
Common (1% to 10%): Febrile neutropenia, lymphopenia
Very common (10% or more): Increased ALT (41%), increased AST (37%)[Ref]
Very common (10% or more): Cough (19%)
Common (1% to 10%): Interstitial lung disease, pneumonitis[Ref]
Very common (10% or more): Headache (20%), dysgeusia (14%), dizziness (13%)[Ref]
Very common (10% or more): Arthralgia (15%)[Ref]
Common (1% to 10%): Venous thromboembolic events[Ref]
Very common (10% or more): Infections (44%)
Frequently asked questions
- What type of drug is Verzenio?
- Is Verzenio better than Ibrance?
- Can you take Verzenio after Ibrance fails?
- How long do you take Verzenio for?
- How long does it take Verzenio to work?
- Is Verzenio (abemaciclib) a chemo drug?
- How effective is Verzenio?
More about Verzenio (abemaciclib)
- During Pregnancy or Breastfeeding
- Dosage Information
- Patient Tips
- Imprints, Shape & Color Data
- Drug Interactions
- Pricing & Coupons
- En Español
- 4 Reviews
- Drug class: CDK 4/6 inhibitors
- FDA Approval History
Related treatment guides
1. "Product Information. Verzenio (abemaciclib)." Lilly, Eli and Company, Indianapolis, IN.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.