Comparing Glucophage vs Rybelsus
| Glucophage (metformin) | Rybelsus (semaglutide) |
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| Glucophage (metformin) | Rybelsus (semaglutide) |
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|---|---|---|
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Prescription only
Prescribed for Type 2 Diabetes. Glucophage may also be used for purposes not listed in this medication guide. |
Prescription only
Rybelsus (semaglutide) is an oral medicine that can be used as a first-line medication to improve blood sugar control in adults over the age of 18 with type 2 diabetes. It works by mimicking the... View more |
Related suggestions Type 2 Diabetes
Popular comparisons
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| More about Glucophage (metformin) | More about Rybelsus (semaglutide) | |
| Ratings & Reviews | ||
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Glucophage has an average rating of 6.9 out of 10 from a total of 39 ratings on Drugs.com. 62% of reviewers reported a positive effect, while 23% reported a negative effect. |
Rybelsus has an average rating of 6.5 out of 10 from a total of 315 ratings on Drugs.com. 49% of reviewers reported a positive effect, while 22% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||
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View all Glucophage side effects |
View all Rybelsus side effects |
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| Drug Class | ||
| Generic Availability | ||
| Pricing and Coupons * Prices are without insurance | ||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | ||
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| Brand Names | ||
| Other metformin brands include: Glumetza | Other semaglutide brands include: Ozempic, Wegovy | |
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||
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4.5 hours |
168 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||
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A total of 381 drugs are known to interact with Glucophage:
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A total of 275 drugs are known to interact with Rybelsus:
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| Alcohol/Food/Lifestyle Interactions | ||
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| Disease Interactions | ||
| First Approval Date | ||
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March 03, 1995 |
September 20, 2019 |
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| WADA Class View classifications | ||
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N/A |
N/A |
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| More Information | ||
| Patient Resources | ||
| Professional Resources | ||
| Related Treatment Guide | ||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.