Glucophage Side Effects
Generic Name: metformin
Note: This document contains side effect information about metformin. Some of the dosage forms listed on this page may not apply to the brand name Glucophage.
Common side effects of Glucophage include: lactic acidosis, diarrhea, nausea, and vomiting. Other side effects include: decreased vitamin b12 serum concentrate. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to metformin: oral solution, oral tablet, oral tablet extended release
Along with its needed effects, metformin (the active ingredient contained in Glucophage) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking metformin:
- Abdominal or stomach discomfort
- cough or hoarseness
- decreased appetite
- fast or shallow breathing
- fever or chills
- general feeling of discomfort
- lower back or side pain
- muscle pain or cramping
- painful or difficult urination
- blurred vision
- chest discomfort
- cold sweats
- cool, pale skin
- difficult or labored breathing
- fast, irregular, pounding, or racing heartbeat or pulse
- feeling of warmth
- increased hunger
- increased sweating
- redness of the face, neck, arms, and occasionally, upper chest
- shortness of breath
- slurred speech
- tightness in the chest
- unusual tiredness or weakness
- Behavior change similar to being drunk
- difficulty with concentrating
- lack or loss of strength
- restless sleep
- unusual sleepiness
Some side effects of metformin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Acid or sour stomach
- excess air or gas in the stomach or intestines
- full feeling
- loss of appetite
- metallic taste in the mouth
- passing of gas
- stomach upset or pain
- weight loss
- Abnormal stools
- bad, unusual, or unpleasant (after) taste
- change in taste
- difficulty with moving
- discoloration of the fingernails or toenails
- flu-like symptoms
- joint pain
- metallic taste in mouth
- runny nose
- stuffy nose
- swollen joints
For Healthcare Professionals
Applies to metformin: compounding powder, oral solution, oral tablet, oral tablet extended release
Gastrointestinal events such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite have been frequently reported during therapy initiation and resolve spontaneously in most cases.
Adverse events in the pediatric population appear to be similar in nature and severity to that published in adults.[Ref]
Common (1% to 10%): Hypoglycemia
Common (1% to 10%): Asthenia, chills, flu syndrome, accidental injury[Ref]
Very rare (less than 0.01%): Liver function test abnormalities, hepatitis[Ref]
Common (1% to 10%): Chest discomfort, flushing, palpitation[Ref]
Common (1% to 10%): Rash, nail disorder, increased sweating
Frequency not reported: Reduction in thyrotropin (TSH) levels[Ref]
Very common (10% or more): Infection (20.5%)[Ref]
Common (1% to 10%): Myalgia[Ref]
Common (1% to 10%): Lightheadedness, taste disturbances[Ref]
Common (1% to 10%): Headache[Ref]
Common (1% to 10%): Rhinitis[Ref]
1. "Product Information. Fortamet (metFORMIN)." Physicians Total Care, Tulsa, OK.
2. "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Glumetza (metFORMIN)." Biovail Pharmaceuticals Canada, Mississauga, IA.
5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
6. "Product Information. Riomet (metFORMIN)." Ranbaxy Pharmaceuticals, Jacksonville, FL.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
- How long does glucophage/Metformin stay in your system?
- What are the ingredient drugs contained in Qternmet XR?
More about Glucophage (metformin)
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
- Support Group
- Pricing & Coupons
- En Español
- 27 Reviews
- Generic Availability
- Drug class: non-sulfonylureas
- FDA Alerts (1)