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What is the safest diabetes medication?

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 20, 2022.

Official answer


Most experts consider metformin to be the safest medicine for type 2 diabetes because it has been used for many decades, is effective, affordable, and safe. Metformin is recommended as a first-line treatment for type 2 diabetes by the American Diabetes Association (ADA).

  • Type 2 diabetes: Which medication is best for me? Harvard Health Publishing School. November 5, 2020.

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