Comparing Esketamine vs Ketamine
| Esketamine | Ketamine |
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| Esketamine | Ketamine |
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Prescription only
Prescribed for Major Depressive Disorder, Depression, Major Depressive Disorder with Acute Suicidal Ideation. Esketamine may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Depression, Pain, Anesthesia. Ketamine may also be used for purposes not listed in this medication guide. |
Related suggestions Depression
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| More about Esketamine | More about Ketamine | ||||||||
| Ratings & Reviews | |||||||||
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Esketamine has an average rating of 6.3 out of 10 from a total of 135 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect. |
Ketamine has an average rating of 5.6 out of 10 from a total of 166 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 45% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Esketamine side effects |
View all Ketamine side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Ketamine prices |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
| Spravato | Ketalar | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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12 hours |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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| Pregnancy Category | |||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 297 drugs are known to interact with Esketamine:
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A total of 422 drugs are known to interact with Ketamine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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N/A |
February 19, 1970 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.