Comparing Esketamine vs Ketamine
| Esketamine | Ketamine |
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| Esketamine | Ketamine |
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Prescription only
Prescribed for Major Depressive Disorder, Depression, Major Depressive Disorder with Acute Suicidal Ideation. Esketamine may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Depression, Pain, Anesthesia. Ketamine may also be used for purposes not listed in this medication guide. |
Related suggestions Depression
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| More about Esketamine | More about Ketamine | ||||||||
| Ratings & Reviews | |||||||||
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Esketamine has an average rating of 6.3 out of 10 from a total of 135 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 29% reported a negative effect. |
Ketamine has an average rating of 5.6 out of 10 from a total of 166 ratings on Drugs.com. 48% of reviewers reported a positive effect, while 45% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | |||||||||
View all Esketamine side effects |
View all Ketamine side effects |
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| Drug Class | |||||||||
| Generic Availability | |||||||||
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N/A |
Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | |||||||||
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We could not find an exact match for this medicine. Try searching the Price Guide directly. |
View all Ketamine prices |
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| Dosage Forms | |||||||||
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N/A |
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| Brand Names | |||||||||
| Spravato | Ketalar | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | |||||||||
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12 hours |
1 hour |
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| CSA Schedule 1 View glossary of CSA terms | |||||||||
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Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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| Pregnancy Category | |||||||||
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Summary unavailable. See the full pregnancy warnings document. |
Category N
Not classified
See the full pregnancy warnings document. |
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| Drug Interactions | |||||||||
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A total of 296 drugs are known to interact with Esketamine:
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A total of 422 drugs are known to interact with Ketamine:
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| Alcohol/Food/Lifestyle Interactions | |||||||||
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| Disease Interactions | |||||||||
| First Approval Date | |||||||||
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N/A |
February 19, 1970 |
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| WADA Class View classifications | |||||||||
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N/A |
N/A |
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| More Information | |||||||||
| Patient Resources | |||||||||
| Professional Resources | |||||||||
| Related Treatment Guide | |||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.