Clozapine Alternatives Compared
| Clozapine | Rexulti (brexpiprazole) | Seroquel (quetiapine) |
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| Clozapine | Rexulti (brexpiprazole) | Seroquel (quetiapine) |
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Prescription only
Prescribed for Schizophrenia, Borderline Personality Disorder, Paranoid Disorder. Clozapine may also be used for purposes not listed in this medication guide. |
Prescription only
Rexulti is an atypical antipsychotic that may be used to treat adults with schizophrenia or depression, or used to relieve agitation associated with dementia in Alzheimer's disease. Most people... View more |
Prescription only
Seroquel is an antipsychotic that helps to calm and relieve psychotic thoughts. It is often given because it is quite sedating; however, care is needed because it also lowers blood pressure... View more |
Related suggestions |
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| More about Clozapine | More about Rexulti (brexpiprazole) | More about Seroquel (quetiapine) | ||||||||||||||||||||||||
| Ratings & Reviews | ||||||||||||||||||||||||||
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Clozapine has an average rating of 7.8 out of 10 from a total of 77 ratings on Drugs.com. 73% of reviewers reported a positive effect, while 17% reported a negative effect. |
Rexulti has an average rating of 6.6 out of 10 from a total of 474 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 26% reported a negative effect. |
Seroquel has an average rating of 7.0 out of 10 from a total of 686 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 21% reported a negative effect. |
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| Drug Class | ||||||||||||||||||||||||||
| Side Effects | ||||||||||||||||||||||||||
| Generic Availability | ||||||||||||||||||||||||||
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Lower cost generic |
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| Pricing and Coupons * Prices are without insurance | ||||||||||||||||||||||||||
View all Clozapine prices |
View all Rexulti prices |
View all Seroquel prices |
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| Dosage Forms Available | ||||||||||||||||||||||||||
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| Brand Names | ||||||||||||||||||||||||||
| Clopine, Clozapine Synthon, Clozaril, Denzapine, Versacloz |
N/A |
Other quetiapine brands include: Seroquel XR | ||||||||||||||||||||||||
| Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | ||||||||||||||||||||||||||
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10.3 hours |
91 hours |
6 hours |
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| CSA Schedule ** View glossary of terms | ||||||||||||||||||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||||||||||||||||||
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Category B
No proven risk in humans
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||||||||||||||||||
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A total of 935 drugs are known to interact with Clozapine:
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A total of 591 drugs are known to interact with Rexulti:
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A total of 736 drugs are known to interact with Seroquel:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||||||||||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||||||||||||||||||
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| First Approval Date | ||||||||||||||||||||||||||
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September 26, 1989 |
July 10, 2015 |
September 26, 1997 |
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| WADA Class View World Anti-Doping Agency classifications. | ||||||||||||||||||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||||||||||||||||||
| Patient resources | ||||||||||||||||||||||||||
| Professional Resources | ||||||||||||||||||||||||||
| Related Treatment Guide | ||||||||||||||||||||||||||
** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.