Comparing Bupropion / Naltrexone vs Wegovy

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Bupropion / naltrexone	Wegovy (semaglutide)	Enter another drug to compare

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Bupropion / naltrexone	Wegovy (semaglutide)	Enter another drug to compare
Prescription only Prescribed for Weight Loss (Obesity/Overweight). Bupropion / naltrexone may also be used for purposes not listed in this medication guide.	Prescription only Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction, Nonalcoholic Steatohepatitis. Wegovy may also be used for purposes not listed in this medication guide.	Related suggestions Weight Loss (Obesity/Overweight) Phentermine Topiramate Semaglutide Zepbound Tirzepatide Adipex-P
More about Bupropion / naltrexone	More about Wegovy (semaglutide)
Ratings & Reviews
Bupropion / naltrexone has an average rating of 6.6 out of 10 from a total of 2079 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 25% reported a negative effect.	Wegovy has an average rating of 7.6 out of 10 from a total of 532 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 15% reported a negative effect.
View all 2079 reviews	View all 532 reviews
Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.
Nausea (32.3%) Headaches (17.5%) Constipation (12.0%) Dizziness (11.2%) Dry mouth (9.0%) Tiredness (5.8%) Anxiety (5.2%) View all Bupropion / naltrexone side effects	Nausea (32.3%) Constipation (15.6%) Vomiting (11.1%) Diarrhea (9.8%) Headaches (7.1%) Heartburn (6.4%) Tiredness (6.4%) View all Wegovy side effects
Drug Class
Anorexiants	GLP-1 Agonists (Incretin Mimetics)
Generic Availability
N/A	No lower cost generic approved
Pricing and Coupons * Prices are without insurance
We could not find an exact match for this medicine. Try searching the Price Guide directly.	We could not find an exact match for this medicine. Try searching the Price Guide directly.
Get free Discount Card	Get free Discount Card

Dosage Forms
N/A	Subcutaneous solution
Brand Names
Contrave	Other semaglutide brands include: Ozempic, Rybelsus
Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.
21 hours	168 hours
CSA Schedule ¹ View glossary of CSA terms
N Not a controlled drug Is not subject to the Controlled Substances Act.	N Not a controlled drug Is not subject to the Controlled Substances Act.
Pregnancy Category
X Category X Not for use in pregnancy See the full pregnancy warnings document.	Summary unavailable. See the full pregnancy warnings document.
Drug Interactions
A total of 783 drugs are known to interact with Bupropion / naltrexone: 220 major drug interactions (958 brand and generic names) 558 moderate drug interactions (2599 brand and generic names) 5 minor drug interactions (16 brand and generic names)	A total of 275 drugs are known to interact with Wegovy: 16 major drug interactions (37 brand and generic names) 258 moderate drug interactions (1458 brand and generic names) 1 minor drug interactions (10 brand and generic names)
Alcohol/Food/Lifestyle Interactions
Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures... View more	Food may affect the absorption of semaglutide when taken orally. It is recommended that oral... View more Talk to your doctor before using alcohol together with semaglutide. Alcohol may affect blood... View more
Disease Interactions
Suicidality Seizure disorders Hepatic dysfunction Angle closure glaucoma Liver disease Mixed/manic episode Renal dysfunction Hepatic/renal dysfunction Weight loss	Suicidal behavior and ideation Thyroid cancer GI adverse events Hypoglycemia Pancreatitis Retinopathy
First Approval Date
September 10, 2014	N/A
WADA Class View classifications
N/A	N/A
More Information
Side effects Drug interactions Dosage Pregnancy warnings Support group En español	Side effects Drug interactions Dosage Pregnancy warnings Breastfeeding warnings Drug images Support group
Patient Resources
Bupropion / naltrexone uses Advanced reading	Wegovy uses
Professional Resources
Monograph (AHFS) Prescribing information	Prescribing information
Related Treatment Guide
Weight Loss (Obesity/Overweight)	Weight Loss (Obesity/Overweight) Cardiovascular Risk Reduction Nonalcoholic Steatohepatitis

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Comparing Bupropion / Naltrexone vs Wegovy

See also:

Wegovy

Zepbound

Mounjaro

Ozempic

Rybelsus

Victoza

Saxenda

Alli

Phentermine

Tirzepatide

Further information