Comparing Buprenorphine vs Probuphine
Buprenorphine Remove Buprenorphine from your drug comparison | Probuphine Remove Probuphine from your drug comparison |
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Buprenorphine Remove Buprenorphine from your drug comparison | Probuphine buprenorphine Remove Probuphine from your drug comparison | ||||||||||||||||
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Buprenorphine is a potent analgesic that should be only used to treat moderate to severe pain or for the treatment of opioid addiction under strict conditions. Different formulations of the drug have... View more |
Prescribed for Opiate Dependence, Opiate Dependence - Maintenance. Probuphine may also be used for purposes not listed in this medication guide. |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.7
For Chronic Pain: I had been on OxyContin 5mg three times a day for years and years with Vicodin higher strength for breakthrough pain. I retired in 2017 and moved from California to Oregon and the opiate crisis was and still is in full bloom here. I was given OxyContin 5mg three time a day by my primary nurse practitioner for about 9 months but was then sent to a PM specialist. He switched me to buprenorphine 1mg tie. After having tried the patch which was alright but my copay was $109.00/month. He wanted to start me on the film one but the copay for that was $160.00/month . So now (just started the dissolvable pill 2mg but cut in half for a 1mg dose tie. Buprenorphine works for me most of the time but I could really use something else for breakthrough pain. Not gonna happen for me. I just want good pain relief, not a “high”. I guess that it’s too much to ask for. |
10.0
For Opiate Dependence: I spent half my adult life addicted to opiates. Every effort, every treatment, every commitment failed. Probuphine is the only treatment that worked long term. I was able to immediately have a normal life without cravings, or worrying about Suboxone regimens. It works, it saved my life. For Opiate Dependence: I seen this drug work, change the lives of people that go on it. Amazing drug finally living a normal life and not worrying about forgetting to take it or losing it. |
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Drug Class |
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Side Effects |
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Commonly reported side effects include: constipation, dizziness, drowsiness, headache, and nausea. See the full buprenorphine side effects document. |
See the full Probuphine side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all buprenorphine prices |
View all Probuphine prices and generic prices |
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Generic Availability |
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Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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Belbuca, Buprenex, Butrans, Probuphine, Sublocade | Other buprenorphine brands include: Belbuca, Buprenex, Butrans, Sublocade | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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48 hours |
48 hours |
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CSA Schedule**View glossary of terms. |
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Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
Moderate abuse potential
Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |
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Pregnancy Category |
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Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
Category C
Risk cannot be ruled out
See the full Pregnancy Warnings document. |
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FDA Alerts |
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Drug Interactions |
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A total of 624 drugs are known to interact with buprenorphine:
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A total of 624 drugs are known to interact with Probuphine:
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Alcohol/Food/Lifestyle Interactions |
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Disease Interactions |
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First Approval Date |
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October 08, 2002 |
May 26, 2016 |
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WADA ClassView World Anti-Doping Agency classifications. |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Chronic Pain: I have had Fibromyalgia for 25 years +-, degeneration of the cervical spine and bulge of several discs in my lower back and neck which each area needs surgery but I refuse to go through it. I don't like being on buprenorphine because of the stigma behind it and having to go to the Dr. once a month I was on tramadol for 19 years which work well most of the time but it was starting to impact my liver enzymes and with both parents dying of liver cancer I wanting to reduce my risk. After 2-3 months on Buprenorphine 8M twice daily my liver enzymes went from 4X the upper limit to 1.5X the upper limit and is now almost under the upper limit. Using ultrasound my liver was 50% larger than it should be, now it is normal.