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Zoledronic acid User Reviews & Ratings (Page 5)

Brand names: Reclast, Zometa, Aclasta

Zoledronic acid has an average rating of 5.0 out of 10 from a total of 412 reviews on Drugs.com. 35% of reviewers reported a positive experience, while 46% reported a negative experience.

Reviews for Zoledronic acid

Commonly mentioned side effects
  • Hon...
  • Taken for less than 1 month
  • February 6, 2025

For Osteoporosis "I’m a 57-year-old woman. I had my first infusion of Reclast Monday morning. I drank water during the procedure. I was not informed to drink water prior. I felt fine after the infusion. By the evening, I started feeling achy. Tuesday, I couldn’t go into work. I had a 101.6 fever, shaking, chills, joint pain, migraine, all-over body aches, and slept pretty much all day. I cannot take Tylenol due to another medical condition, so I took Naproxen 2x that day. Wednesday, I woke up without chills, a temperature of 99.4, and ate a little something. I still feel achy and hope to feel better tomorrow. I’m rethinking taking this medication ever again. Very painful side effects."

5 / 10
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6 Report
  • AMA...
  • Taken for 6 months to 1 year
  • January 1, 2020

For Osteoporosis "I had the Reclast infusion back in March 2019. I have experienced more bone pain than I did prior to the infusion. Still in pain. The day after I had the infusion I had to go to the ER due to higher than normal blood pressure. 196/102. A headache, etc. Is this normal to still be in pain and fatigued?"

2 / 10
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56 Report
  • Ann...
  • Taken for less than 1 month
  • January 27, 2020

For Prevention of Osteoporosis "I received a Reclast infusion on December 26, 2019, for osteopenia. The next night, I awoke with a terrible headache and was unable to ignore it. I took a pain reliever and slept for 4 hours only to awaken again in severe head pain. The next day, I still felt truly horrible. I went to the ER because it was a Saturday, where I had an X-ray of my neck, and the ER doctor gave me 4 trigger point injections of lidocaine in the base of my skull. Still fighting pain! Additional trigger point injections. When does it end? A month so far of pain. Don’t do it!!"

1 / 10
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56 Report

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Frequently asked questions

  • Bet...
  • Taken for 5 to 10 years
  • June 19, 2018

For Osteoporosis "I am 73 years old, have been using Reclast injections once a year for 7 or more years. My last bone density test showed good improvement. I had slight soreness the first time and have had zero side effects since. I am going in today for another test. I guess we all tolerate different things, I take no other medications whatsoever. But for me, this seems to be working."

10 / 10
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69 Report
  • Wil...
  • Taken for less than 1 month
  • May 24, 2022

For Prevention of Osteoporosis "Horrible. Within 48 hours of infusion, I developed chills, fever 101.4, subsequent joint pain, and then swelling in the carpometacarpal joint. Right knee started with pain, and within 24 hours, I had a complete knee effusion with inability to bear weight. Knee was swollen twice its size."

4 / 10
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36 Report

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  • Pat...
  • Taken for 2 to 5 years
  • January 21, 2024

For Osteoporosis "I had my 2nd Reclast infusion a week ago. Drank plenty of water before and after. Took precautionary acetaminophen for two days after. No side effects whatsoever. There was an improvement in bone density after 1st time (3 years ago)."

10 / 10
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19 Report
  • Blo...
  • May 22, 2020

For Osteoporosis "I will never try Zometa again. I had horrific side effects. I passed out 7 hours after home from infusion, my neighbor called paramedics. My blood pressure dropped to 80/58. I’ve had full body ache, headache, sweats, and chills for 3 days so far."

1 / 10
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54 Report
  • Gly...
  • July 17, 2022

For Osteoporosis "I had my first fusion/drip on the 31st of May 2022, as I couldn't tolerate Fosavance. By 1st of June 2022, a few hours after Aclasta was administered, I felt like all the bones in my whole body were attacked. I was crippled by this pain. As the pain was so debilitating, I landed up in the hospital for about 3 weeks during June for pain control. I was on a daily drip. I'm still not right. I am due to see a pain specialist. I feel there are too many pain signals going to the brain. My pain meds aren't helping. I take a sleeping tablet, but I'm awake most of the night. So I am sleep deprived and in constant pain, it's a nightmare. This pharmaceutical should be accountable for the pain and suffering endured."

1 / 10
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33 Report
  • Ava...
  • Taken for 2 to 5 years
  • November 13, 2016

For Osteoporosis "I have Osteogenesis Imperfecta. After getting Aredia for years and not seeing much improvement (maybe it prevented deterioration), I received Aclasta for 2 years and my bone density went from very fragile to just below average. That was 2 years ago. No side effects and no deterioration as of yet. I'm very happy to be repaired."

10 / 10
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75 Report
  • Sue...
  • Taken for 2 to 5 years
  • June 5, 2013

For Osteolytic Bone Metastases of Solid Tumors "I have been receiving Zometa via IV infusion for about 3 years now. At first, three weekly, then after about a year, four weekly. I have breast cancer and bone metastasis. If I take the infusion over 15 minutes, during the following day I will begin with severe vomiting and flu symptoms, which last for two days and nights, after which I'm fine. However, if I have the infusion over 30 minutes - as advised on the internet way back in the early days of my treatments - I have NO side effects whatsoever, no sickness, no aches, and pains! I have spoken to other women who have experienced the same - take the infusion slower, drink plenty of water, and you might just find your horrid side effects disappear!"

8 / 10
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100 Report
  • Jms...
  • Taken for 6 months to 1 year
  • April 6, 2022

For Hypercalcemia of Malignancy "I agree with other reviewers, you will experience all side effects listed. I have had 7 infusions (1 monthly) for 1 year. After infusion, I’m fine for a day. Usually, 1-2 weeks after, I will be extremely tired, with bloating and burning skin on abdomen. Side effects vary monthly."

2 / 10
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37 Report
  • Jac...
  • Taken for less than 1 month
  • June 16, 2017

For Osteolytic Bone Metastases of Solid Tumors "Had my first dose on Monday, 12th June 2017. I was fine Monday night, so I felt quite positive. Woke up Tuesday feeling like death! Wednesday, I felt better but had a painful, red, swollen left eyeball. Long story short, I'm in agony with my eye, and no one knows what to do! The hospital tried to say it wasn't a side effect! It's a very rare side effect, but it is one! And the fact they know nothing about it or how to deal with it is disgusting and frightening! I will not be having this treatment again and will be taking this further! They should not be giving people something if they don't know everything about it!"

2 / 10
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71 Report
  • Kat...
  • Taken for less than 1 month
  • February 3, 2022

For Osteoporosis "Received 1st dose on Monday at 9:30 a.m. Felt okay, a bit tired in the afternoon. However, at around 9:00 p.m., pains in my sternum started. I took Panadol as advised, went to bed. By midnight, I was shivering and shaking and ached all over, then intense pain set in, in my sternum and left breast and arm. I could hardly breathe and seated, coughing. Temperature rose to 40 and severe sweats. More Panadol, which did nothing. Pain worsened and could hardly walk. In the morning, I phoned the lady who administered Aclasta, who said it was all normal and could subside in a day or two. Phoned my doctor, who sent me straight to the hospital, where I spent the next 12 hours on pain relief, a drip, and tests for suspected blood clots, thankfully none. I was kept until my temperature dropped and my blood pressure (190/98) returned to its usual 130/75. Day 3, sternum pain has lessened to bearable, right arm still very painful, as is my back. Very tired and nauseous. I wish I had read these reviews."

1 / 10
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37 Report
  • Suz...
  • Taken for 1 to 6 months
  • May 7, 2019

For Osteoporosis "I had the Reclast infusion on April 4th, and 12 hours later I had severe chills (shaking so bad I couldn't close my mouth to take my temp) and fever. Lasted for 6 hours. Then I was sick to my stomach for the next day with severe pain in my legs (hard to get up from a chair) and my hands (hurt to write). Then I started with a 'cold' sinus/bronchial infection, which sent me to urgent care for an inhaler and cough medicine. Back to the doctor after 5 days for antibiotics, and I'm still sick one month later. Now jaw pain on the left side, and my teeth hurt. I will NEVER take Reclast EVER again. I hope you won't either!!!"

1 / 10
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61 Report
  • Mel...
  • July 26, 2020

For Prevention of Osteoporosis "Just had my first Reclast infusion on July 23, 2020. Just getting out of bed for the first time in 3 days. I have side effects of the worst pain ever in my bones and my head, hands, back! I felt like every bone in my body was punched, kicked, and crushed. I could feel each bone ache individually (if that makes sense). Headache was so bad I got sick. However, day 3 is the magic number, and I am feeling much better ;). It has been very bad, but I have made it through with lots of rest, laying in bed watching movies. I think for me it was worse than chemo, yuck feeling. *** Don’t know how effective until next year."

5 / 10
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49 Report
  • McG...
  • Taken for 1 to 6 months
  • January 28, 2023

For Osteoporosis "I had a 15-minute infusion 5 days ago. For about 16 hours, I felt fine. The following afternoon, I began to feel a headache, tiredness, and generally felt ill. Tried sleeping it off. The next afternoon, my chest felt sore, I had severe pain, like indigestion, for most of the night. Day three, my joints have swollen and I have arthritic symptoms, my wrists are extremely painful, it hurts to even press the toilet button. I still have headaches. I regret having Aclasta. I am not prepared to recommend it at this stage."

1 / 10
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30 Report
  • wha...
  • Taken for less than 1 month
  • September 2, 2020

For Osteoporosis "Female, 78 years young! First Reclast infusion in July 2020, no one told me to drink extra water prior to infusion. While still at the center, I started getting a bad stomach ache, which lasted 3 days. It was BAD, the first 18 hours unbearable - Dexa score 2018 -2.5, 2019 -2.9, July -3.2 - I've taken 1,200 Calc with D3 for years, also Magnesium daily, eat well, osteoarthritis and porosis in feet really bad, fingers and hips - feeling fine now, no other side effects noted."

7 / 10
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50 Report
  • Fat...
  • Taken for less than 1 month
  • October 30, 2014

For Osteoporosis "Had my infusion yesterday. I drank a few glasses of water in the morning and took an ibuprofen during the treatment. I had expected the '3 days of flu-like symptoms' and even scheduled sick time to be prepared. Zero side-effects, no aches or pains, nothing...but still taking the time off so I can have fun. My stats: 50, 100#, just finished 2 years of Forteo, I take 1200mg Calcium a day plus an Rx Vitamin D each month."

6 / 10
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89 Report
  • Lau...
  • Taken for less than 1 month
  • July 31, 2022

For Prevention of Osteoporosis "I had my first infusion of Reclast on a Wednesday afternoon. By 3 AM Thursday morning, I had fever, chills, and extreme body aches. Nauseated and a headache. Pretty extreme, took Tylenol, got a little relief. The next 24-48 hours have been pretty terrible, still slowly recovering. Will not do this infusion ever again. I was told by the nurses, 'Well, you might feel a little achy,' that wasn’t even close to how bad I felt."

2 / 10
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31 Report
  • Hen...
  • Taken for less than 1 month
  • September 2, 2019

For Osteoporosis "After being reassured by 2 physicians, one an MD, another oncologist: that this option for infusion would offset any negative side effects for the benefit I would receive. Couldn't have been more untrue in my case. After infusion, bedridden for 3 days with limited movement due to extremely painful joints. Been 8 days now, and I'm just now getting back on my feet but weak. Please get multiple opinions from all before considering this medication. Never again."

1 / 10
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54 Report
  • Man...
  • July 17, 2020

For Osteoporosis "55-year-old with osteoporosis (genetic predisposition as well as early menopause). Had my first infusion yesterday. Did prep with lots of water and Tylenol (hence up peeing throughout the night). Today I am sore, stiff, have a headache, and fatigued. But all manageable with Tylenol and Advil (taken 2 hours apart). Deep breaths hurt and took an almost 3-hour nap today (at least during the pandemic I don’t have to work)."

7 / 10
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46 Report
  • Con...
  • Taken for less than 1 month
  • February 7, 2020

For Osteoporosis "Feb 7th update. I did my original post on Jan 30 under the same name, about having the Reclast infusion on Jan. 27, 2020. Just so you know how long the side effects for Reclast last, I am still having pain in my legs, blurred vision, some nausea, and headache, but able to get up and down the stairs now, eating a little bit better. Starting to feel a little better."

4 / 10
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49 Report
  • Bam...
  • Taken for less than 1 month
  • November 19, 2019

For Osteoporosis "Had my first infusion Nov 15, 2019. I started getting the flu-like symptoms about 8 hours later. Thought it was the end of me. I shook for 2 days with chills. Couldn’t pick my arm up to get the Tylenol off my nightstand. 5 hours later, I finally got them and every blanket I owned. It hurt so much. Then started with throwing up and diarrhea. It’s been 4 days, and I’m still in bed, beyond tired. Not sure how to rate the medicine because it hasn’t started to work yet. But the side effects are really bad. Make sure you have lots of water, Gatorade, and Tylenol or pain meds, you’ll need them."

6 / 10
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49 Report
  • Rec...
  • May 7, 2017

For Osteoporosis "Had the infusion twice. The only side effect the first time was a slight headache. The second time, no side effects at all. I highly recommend having this. Make sure you are well-hydrated the day of the procedure."

10 / 10
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70 Report
  • CJa...
  • Taken for 6 months to 1 year
  • May 1, 2021

For Osteoporosis "I have been in pain for over 6 months after Reclast. Picking up a tiny cup of water sends pain to my back. I am okay if resting. Pain in all joints and bones. I am 82. Never a bit of pain prior to this infusion. I have never fallen as an adult. I was never told by my doctor to drink water a day prior. I would like to join a lawsuit if there is one."

1 / 10
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42 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.