Skip to Content

Zoledronic Acid (Bone Health)

Generic Name: Zoledronic Acid (Bone Health) (ZOE le DRON ik AS id)
Brand Name: Reclast

Medically reviewed on May 2, 2018

Uses of Zoledronic Acid:

  • It is used to treat Paget's disease.
  • It is used to put off or treat soft, brittle bones (osteoporosis).
  • It may be given to you for other reasons. Talk with the doctor.

What do I need to tell my doctor BEFORE I take Zoledronic Acid?

  • If you have an allergy to zoledronic acid or any other part of zoledronic acid (bone health).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have low calcium levels.
  • If you have kidney disease.
  • If you are taking or will be taking another drug like this one.
  • If you are taking another drug that has the same drug in it.
  • If you are pregnant or may be pregnant. Do not take zoledronic acid (bone health) if you are pregnant.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with zoledronic acid (bone health).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take zoledronic acid (bone health) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Zoledronic Acid?

  • Tell all of your health care providers that you take zoledronic acid (bone health). This includes your doctors, nurses, pharmacists, and dentists.
  • Worsening of asthma has happened in people taking drugs like this one. Talk with the doctor.
  • This medicine may raise the chance of a broken leg. Talk with the doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Have a bone density test as you have been told by your doctor. Talk with your doctor.
  • Take calcium and vitamin D as you were told by your doctor.
  • Have a dental exam before starting zoledronic acid (bone health).
  • Take good care of your teeth. See a dentist often.
  • This medicine works best when used with calcium/vitamin D and weight-bearing workouts like walking or PT (physical therapy).
  • Follow the diet and workout plan that your doctor told you about.
  • Do not give to a child. Talk with your doctor.
  • If you are 65 or older, use zoledronic acid (bone health) with care. You could have more side effects.
  • Use birth control that you can trust to prevent pregnancy while taking zoledronic acid (bone health).
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking zoledronic acid (bone health), call your doctor right away.

How is this medicine (Zoledronic Acid) best taken?

Use zoledronic acid (bone health) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
  • Acetaminophen may be given to lower fever and chills.
  • Drink at least 2 glasses of liquids a few hours before you get zoledronic acid (bone health).

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low calcium levels like muscle cramps or spasms, numbness and tingling, or seizures.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Very bad bone, joint, or muscle pain.
  • Any new or strange groin, hip, or thigh pain.
  • Chest pain.
  • A heartbeat that does not feel normal.
  • Fast or slow heartbeat.
  • Change in eyesight, eye pain, or very bad eye irritation.
  • Mouth sores.
  • Trouble swallowing.
  • Very bad pain when swallowing.
  • Fever or chills.
  • Sore throat.
  • Any unexplained bruising or bleeding.
  • Feeling very tired or weak.
  • Mood changes.
  • Pain where the shot was given.
  • Redness or swelling where the shot is given.
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
  • This medicine may cause jawbone problems. The chance may be higher the longer you take zoledronic acid (bone health). The chance may be higher if you have cancer, dental problems, dentures that do not fit well, anemia, blood clotting problems, or an infection. The chance may also be higher if you are having dental work, getting chemo or radiation, or taking other drugs that may cause jawbone problems like some steroid drugs. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure. Call your doctor right away if you have jaw swelling or pain.

What are some other side effects of Zoledronic Acid?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Zoledronic Acid?

  • If you need to store zoledronic acid (bone health) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time zoledronic acid (bone health) is refilled. If you have any questions about zoledronic acid (bone health), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide