Zepbound and Nausea: What Users Say (Page 4)

• Mec...
• Taken for 1 to 6 months
• July 28, 2024

For Weight Loss (Obesity/Overweight) "Made my anxiety more intense, bad nausea, lightheaded, dizzy, not feeling like myself, not interested in anything, depressed. The only good thing was I was losing weight, very slowly but was losing. I decided to stop Zepbound because I needed to feel like me again and not a nervous, anxious zombie."

• Anonymous
• Taken for 6 months to 1 year
• March 4, 2025

For Weight Loss (Obesity/Overweight) "It was rough in the beginning, with diarrhea, then constipation and heavy belching. The diarrhea ended after about a month, but constipation has continued. In addition to those symptoms, I experienced an undercurrent of nausea for several months, with it being more pronounced just after eating. After about eight months, the nausea abated for the most part. I started on the 2.5 and moved up in dosage every 2 months or so. I am entering month 10 and am on the 12.5 dosage. For the first 6-7 months, I lost approximately 1.5 lbs/wk, and over the last 2-3 months that has slowed down a little. I have lost a total of 50 lbs. The other side effect I've experienced is I sometimes have low blood sugar in the mornings, so I will have juice or something to help take care of it. It is easy to use, and despite the rough start, I am pleased with the results."

• Suz...
• Taken for 6 months to 1 year
• February 26, 2025

For Weight Loss (Obesity/Overweight) "I began my weight loss journey in late January 2024. Over the next 12 months, I lost 40 pounds. However, I've hit a plateau for the past four months, since the end of November 2024, and it's now February 25, 2025. I still need to lose at least another 40 pounds. Zepbound has been a significant help in my journey. My clothes fit much better, and I've gone from a size XXL to a medium. In addition to Zepbound, I also strength train, maintain a healthy diet, and track my calorie intake. The only side effects I've experienced with Zepbound are occasional acid reflux, mild nausea, and some constipation. Currently, I am on 12.5 mg, but my doctor has decided to update my dosage to the 15 mg to see how I do on that dosage. Hopefully, it will kick me over the plateau and I will end up losing the next 40 pounds that I need to. Other than that, I love Zepbound. I think it’s great."

• Tif...
• Taken for 1 to 6 months
• July 24, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound 2.5 mg back in December 2023. I didn’t have any issues from the 4 weeks I was on it, once I went to the 5 mg, I started to get nauseous, but nothing I couldn’t tolerate. By March, I had lost 30 lbs. I started at 270 lbs. Unfortunately, at the end of March, there was a shortage, and it was impossible to get it anywhere. But I kept up on exercising and watching what I ate until the shortage was over. In June, I was finally able to get back on Zepbound 5 mg, and so far, I have lost an additional 20 lbs. I am weighing 220 lbs and feeling great! Not gonna lie, after being off of it for a few months, I have been really nauseous."

• Hai...
• Taken for 1 to 6 months
• December 6, 2024

For Weight Loss (Obesity/Overweight) "The first couple of weeks, I was nauseous throughout the day. I had a hard time eating more than a couple of bites and didn't want to drink anything. Then I made myself eat a very light breakfast, protein drinks for lunch, a small portion of food for supper. Drinking a bottle of water with each meal and an extra one in the evening. Now on my 11th weekend, all's well. Oh, and I had to give up caffeinated coffee, it was contributing to my nausea in the first two weeks. Started at 239 lbs, 5'9'', 69 yrs. old. Now at 210.4 lbs."

• Use...
• Taken for 6 months to 1 year
• March 5, 2025

For Weight Loss (Obesity/Overweight) "I have been using weekly Zepbound shots since July 23rd, 2025…6-7 months. I have lost 47 lbs., which is 23% of my body weight. I have had occasional waves of nausea, but not so bad that it made me want to quit. My sleep has been disrupted some nights when I can’t go back to sleep after waking up. I’m currently up to 7.5 mg. And I’ve started taking the shots every 10 days instead of 7 days so I can gradually wean myself off of it. I have about 5 lbs. to go to meet my personal goal and about 10 lbs. to be off of the “overweight” BMI chart. I have been seeing my doctor every 3 months for bloodwork and check-ups. I am happy that I decided to try Z, and I’m also pleased that my insurance company paid for all of it except for $25 a month. Totally worth it."

• Ano...
• Taken for 1 to 6 months
• May 29, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Dosage 2.5. Effective for sleep apnea and weight loss. Having side effects including queasiness, lightheadedness, diarrhea, constipation, Vitamin B12 blood test elevated to 1270. Starting weight 156. Now 147 after 7 doses."

• Me1...
• Taken for 1 to 6 months
• March 7, 2025

For Weight Loss (Obesity/Overweight) "I started off with 2.5 mg the first month. Second month is 5 mg. Today I take the 3rd needle from the package. Last night was the first time I was nauseous and vomiting. I don't know if it was from the medication, but that day I had eaten chips and chocolate. I had not since I started. I want to believe eating those led me to being sick. Burping started about 3 weeks ago but only lasts for a day. It has happened 3 times. Been stuck on the same weight for 2 weeks."

• Ano...
• Taken for 1 to 6 months
• June 19, 2025

For Weight Loss (Obesity/Overweight) "I am up to a 12.5 dose, almost 4 months on Zepbound. I have only lost 11 lbs. I am on a calorie-restricted diet, 1400 cal per day. I don’t feel a lot of hunger and my cravings are not many. I am disappointed in the loss rate, but if it keeps me from gaining back the weight, I’ll be happy. My only side effects have been constipation and minor nausea."

• Can...
• Taken for 6 months to 1 year
• June 26, 2025

For Weight Loss (Obesity/Overweight) "I have taken Zepbound for 6 months. Every time I go from 2.5 to 5, I get sick. I look at food and feel physically ill. I can’t get past 3 or 4 bites and must stop. I have gone back to 2.5 for a month to start over, but to no avail. Because I couldn’t eat, I have lost 30 pounds. I will now struggle to keep the weight off without the aid of chemicals."

• Kel...
• Taken for less than 1 month
• July 8, 2025

For Weight Loss (Obesity/Overweight) "I just started my 1st shot Mon July 7th 2025. I'm 39 and weigh 231 lbs. Throughout the day, I was fine and eating regularly as usual, but the next morning... OMG! The nausea is horrible, but that won't stop me from losing the 40 lbs I'd like to lose. Drink lots of water, listen to your body, and get plenty of rest."

• Ano...
• Taken for 1 to 6 months
• June 22, 2025

For Weight Loss (Obesity/Overweight) "I started taking Zepbound five weeks ago. I started with 2.5. My first couple of weeks were fine, but by my third week after that shot, I could not eat for 3 days. I tried even sipping on water and couldn't because of the nausea. My throat kind of burnt all the way down to my stomach, it felt like someone was squeezing the top of my throat. I just took my first shot of the 5.0 3 days ago, and I still haven't been able to eat because I'm so nauseous, and again my stomach's hurting. I tried yesterday to take some Rolaids, but that made me throw up. I haven't told my doctor, and I'm still going to continue taking it, but if this keeps up, it's not worth it. But I will continue to try maybe one or two more weeks, but if it just keeps up and is this miserable, I'm going to stop taking it. Hopefully, no one else has this feeling. But I didn't lose 19 lb in one month. I hope everyone does better on it than I am."

• Suz...
• Taken for 1 to 6 months
• January 23, 2025

For Weight Loss (Obesity/Overweight) "Encounter burping, nausea, and can’t fall asleep easily."

• Ano...
• Taken for less than 1 month
• May 14, 2025

For Weight Loss (Obesity/Overweight) "I have lost 14 lbs in 4 weeks. Extreme fatigue and a little nausea. A little shortness of breath when walking. Feeling weak."

• Cry...
• Taken for 6 months to 1 year
• February 21, 2025

For Weight Loss (Obesity/Overweight) "I've lost 67 lbs in 10 months. Only side effects have been some constipation and slight nausea. This has been a life changer for sure!"

• Den...
• Taken for less than 1 month
• July 14, 2024

For Weight Loss (Obesity/Overweight) "Works for weight loss if you can tolerate it. I went to the ER with nausea, vomiting, severe depression, and anxiety. Won't be continuing."

• Nev...
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "Lost 20 pounds on 2.5 mg. No bad reaction. 5.0 has been different. First time very nauseous. Haven’t lost any additional weight. Afraid to move up to 7.5 mg."

• Vio...
• Taken for 1 to 6 months
• November 24, 2024

For Weight Loss (Obesity/Overweight) "For the most part, my biggest side effect has been burping and nausea. Even before using this medication, I had bouts of reflux."

• Suz...
• Taken for 6 months to 1 year
• April 14, 2025

For Weight Loss (Obesity/Overweight) "Having great success with weight loss but having trouble with nausea and vomiting."

• San...
• Taken for 1 to 6 months
• July 2, 2024

For Weight Loss (Obesity/Overweight) "Had just a little nausea. Love the ease of the shot. Weight loss is great."

• Mor...
• Taken for less than 1 month
• July 21, 2025

For Weight Loss (Obesity/Overweight) "So far, so good. I am suffering from the nauseated feeling, burping, fatigue, and muscle cramps. I'm at 2.5 level, week 3. I'm definitely eating a lot less."