Zepbound and Nausea: What Users Say (Page 2)

• JoD...
• Taken for less than 1 month
• September 7, 2025

For Weight Loss (Obesity/Overweight) "I started Zepbound with the expected side effects, chills, extreme fatigue, nausea, massive potty dumps. I am now down with days of horrible abdominal intestinal pain. I cannot go to the bathroom! I have stopped this med."

• ric...
• Taken for less than 1 month
• May 26, 2024

For Weight Loss (Obesity/Overweight) "So, I took one dose, unfortunately, my doctor screwed up and started me at 15mg. I've been in the ED for 36 hours and have had the worst 3 weeks of my life. This is not a review but a caution, check your script thoroughly, make sure you're taking the right dose. I need to purge this dose from my system and then start a 2.5mg dose."

• Jus...
• Taken for less than 1 month
• December 28, 2024

For Weight Loss (Obesity/Overweight) "After my second 2.5 shot, the side effect symptoms are too much for me to handle. I’ve barely kept any food down except for a day and a half before my second shot. I can’t find a way to prevent acute nausea, and the vomiting is now making me weak. I knew there would be side effects, but for me, this medication doesn’t work for my body. I chose to discontinue the medication and will work with my doctor to see what other options may work for me. I have been unable to participate in family and home life, feeling trapped between being so sick I can’t leave my bed and spending a lot of time vomiting or feeling like I will if I try to move or drink water. I hoped this would be the tool to help me on a healthier path, and it’s not the right one for me, but I can see how it would possibly help others if they aren’t affected by side effects."

• Jun...
• Taken for 6 months to 1 year
• January 26, 2025

For Weight Loss (Obesity/Overweight) "I am on the lowest dose and have been on it for several months and have lost 24 lbs. I started off slowly walking 0.5 mile a day for the first week until I was able to do 3 miles a day. I had a friend walk with me, which was a good support. The last month, I have gained 3 lbs. back because of the weather, but I am back on my grind again. So far, no real side effects. When I first started, I felt a little queasy the first 24 hours."

• Fin...
• Taken for 6 months to 1 year
• September 3, 2024

For Weight Loss (Obesity/Overweight) "I started Zepbound in March of this year, along with regular exercise and a more balanced diet. Since then, I have lost 65 lbs. For the first time in over 20 years, I am under 200 lbs. I feel great. I barely use my inhaler, my knees rarely hurt, and I can jog! My labs are all within normal limits, and I feel so much better about myself. I have very little side effects from ZB: nausea the day after I take it, intolerance to most alcoholic beverages, and I get hot after every meal. I’ll take those side effects any day if it means that I’ll continue to have my life back. I’m on the highest dose now and will continue until I reach my goal of 165. I’m 5’4'' and 44 yrs old. I’m not sure that I want to get back to my high school weight of 140 or less. Anyway, I’m not here to steer anyone, I just wanted to share how well it’s going for myself."

• Tri...
• Taken for 1 to 6 months
• September 3, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for a month now, lowest dosage of 2.5 mg, and today I'm to start my second month with the next dosage up, but personally, I'm done. I've lost 7 pounds this August 2025, and though it may not seem like a lot to most people, it's quite something to those of us who have a very hard time losing weight. The thing is, how can a person be happy with the weight loss when you're miserable all the time? My first week went well, but come the second, the stomach aches/cramps and nausea are too much... every day, all day, through the night... sicker than a dog. I've heard good things about Zepbound, but the side effects are just too much for anyone to feel good about the journey it takes you on, and if the side effects only get worse with the higher dosages, then I might as well not eat at all for what little I can now, when I can. I'm 300+ pounds, and this was my last hope for any type of weight loss help. I don't recommend this product, the side effects outweigh any of the happy."

• Mat...
• Taken for 6 months to 1 year
• March 18, 2025

For Weight Loss (Obesity/Overweight) "Question: Why wouldn’t you use this to get a head start on a new life? I started on Monjaro for weight loss and had to switch to Zepbound after three months (insurance). I always dieted and would stall after 20 pounds. My ultimate goal was to lose enough weight to safely run again. After a year, I had lost 80 lbs and was able to start running. I just finished a half marathon, one year after starting this journey. The side effects of it are what is advertised; some nausea, it can hit you but goes away quickly, the heartburn was less with Zepbound than Monjaro, and the decrease in using the bathroom is a godsend for anyone experiencing IBS. The injection is not bad with the auto pen. Take the leap and change your life!"

• Ano...
• Taken for 1 to 6 months
• July 17, 2025

For Weight Loss (Obesity/Overweight) "I have lost 20 lbs in 3 1/2 months on Zepbound taking 2.5, 5.0, and 7.5 mg so far as per plan and dosage increases. I plan to use 5 mg for maintenance dosage now that I am almost at my goal weight. It is very simple to use. I had some GERD, nausea, and adjustments to make with certain foods, but that subsided after the first few months. You definitely cannot overeat as you will not feel well. The exhaustion and body aches are what bother me the most. For the first 3 days after an injection, I am so tired that it impacts what I can get done in a day, including energy to exercise and do my job during the day. I am sleeping okay with it, but the fatigue is almost debilitating."

• Mik...
• Taken for 1 to 6 months
• May 17, 2025

For Weight Loss (Obesity/Overweight) "Started with the initial 2.5 mg injections and experienced queasiness, and though my appetite remained, I got a sick feeling less than halfway through the meal. After 4 weeks, even though I was eating very little, my weight only dropped a few pounds. Then I advanced to 5 mg and my stomach was gassy and totally upset, I ate Tums constantly to control the acid indigestion. The worst part was to come, for one solid week, I was a total insomniac. I mean no sleep. This lasted a little over a week. I stopped with the injections after the first 5 mg one. It is now a month later and most of the symptoms are gone."

• 2go...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "On week 5 of Zep. Goal to lose 20-25 lbs. Received a 2.5 mg 'loading' dose, I split it into 1.25 doses 3 days apart for the first 2 weeks as I tend to react strongly to meds. I had a bit of anxiety and fatigue on this dose and appetite suppression that waned by week 2, so I increased to 2.5 in one shot for weeks 3 and 4. Less anxiety/fatigue but more nausea and constipation, still manageable. I received a 5 mg dose in the mail at week 4 but had already lost 15 lbs on the 2.5 dose for 4 weeks. Week 5 - I tried the 5 mg. The next day, I was so sick to my stomach and nauseous that I struggled to eat or drink at all. I was dizzy and felt terrible, depressed, and kept getting the long bouts of hiccups. I will be at goal soon and plan to switch to metformin to maintain weight. For me, this med is miraculous, but I do not feel great on it. (For reference - I have a mental health diagnosis and pre-existing mild gastrointestinal issues, MTHFR gene variant)"

• Lor...
• Taken for 1 to 6 months
• July 16, 2025

For Weight Loss (Obesity/Overweight) "I started on Zepbound 3 months ago. I began at 2.5 mg the first month and then went to 5 mg for 2 months. I had no side effects whatsoever. I started 7.5 mg last Sunday, and by Tuesday, I was nauseous, vomiting, and had diarrhea. It went away overnight, and now I’m fine, but not sure I want to continue with 7.5 mg due to the side effects. I have lost only 10 lbs in the 3 months I have been on it, but will have to stop taking it if these side effects continue."

• Ms ...
• Taken for 6 months to 1 year
• March 11, 2025

For Weight Loss (Obesity/Overweight) "I started my Zepbound journey in August 2024. I have been on .50 the whole time. I've lost 40 lbs using this medicine, which is amazing! In February, out of nowhere, I started to get side effects after my shot: nausea and diarrhea. Thinking it was the flu, I nursed myself back. Shot day is Wednesdays. On Saturday, the diarrhea came back again. I truly am excited for my weight loss journey but am literally pooped out."

• Ste...
• Taken for 6 months to 1 year
• October 3, 2024

For Weight Loss (Obesity/Overweight) "I've been on the shot for 5 months now, and at first, the appetite suppression was strong, with no side effects. After I went up in dose month two, I had extreme bloating and nausea to the point where I nearly took myself to the emergency room. Since then, the side effects have gone down, and the only one I deal with regularly is heartburn. Ask your doctor for Zantac and keep it and Tums on you at all times. Thankfully, it has mostly subsided, and I'm down 80 pounds with moderate exercise in 5 months. I have basically 0 appetite most days and have grown to work with it. I'd give it a 4/5. It's not easy, but if you're serious about losing weight and taking back control of your body, do it. Make sure you work out and follow a strict diet while you're doing it to get the most out of the medication. ALSO! Go to the manufacturer Lilly's website and sign up for the savers card. Saves me $300 a month with insurance."

• Ms ...
• Taken for 1 to 6 months
• September 8, 2025

For Weight Loss (Obesity/Overweight) "Have been taking for the 6 weeks. I have lost some weight, but I have been so nauseous that it is hard to continue taking. I've also experienced fatigue, and it's already hard with perimenopause. So far, not a good experience, but I'm trying to stick with it to see if it gets better. I have seen it work really well for some family members, so hopefully, it will get better."

• Anonymous
• Taken for 1 to 6 months
• January 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 49-year-old female. Started on 2.5 mg of Zepbound at 201. Lost some weight quickly and got to 191, then stopped. Second month, they bumped me to 5 mg. I only got sick once. It was nausea. I started losing again. Got down to 185. Then, for reasons I can’t explain, I gained 2 lbs despite walking and tracking food. On my 3rd shot, I was very lethargic for a whole weekend after the shot. I have no energy, and I am taking nothing else. I hope it goes away soon and I start losing again. It’s not a magic bullet. You have to track your food and exercise too (which is hard with lethargy)."

• Anonymous
• Taken for 1 to 6 months
• December 17, 2024

For Weight Loss (Obesity/Overweight) "I am 5'2" and 46 years old. I started Zepbound on 8/20/2024 at 166 pounds. I took the 2.5 mg dose for one month, then increased to 5 mg in Oct. and Nov. I had very mild side effects, and I steadily lost weight until last week. I have now increased to the 7.5 mg dose, and the nausea and diarrhea are pronounced. I'm down 30 pounds, but I may switch back to the 5 mg dose if the side effects don't subside."

• mir...
• Taken for less than 1 month
• August 12, 2025

For Weight Loss (Obesity/Overweight) "On my first week I am down 9 pounds already. My problem was never overeating. I am 5'7" 295. I have always eaten healthy and exercised. Come to find out my hormones are off. This shot has balanced everything out and I feel great. Some side effects: first few days I was extremely tired, now I have a ton of energy. I am also very nauseous. Make sure you get 100 mg of protein a day to maintain muscles."

• Ano...
• Taken for 1 to 6 months
• August 9, 2025

"I was prescribed Zepbound as a minor by my PCP since a close relative had great improvement of symptoms on the drug. I had moderate/severe side effects, including severe abdominal pain, complete lack of appetite leading to hypoglycemia, exhaustion and weakness, increased stress, nausea, IBS flare-ups, and significantly increased suicidality. While my lab results showed improvement, my physical and mental well-being plummeted. I was told that side effects would subside and that they were mild, but unfortunately my side effects did not subside and were unmanageable for me. Luckily, I was able to convince my doctor that it wasn’t working after a few more months and am now off the drug."

• Day...
• Taken for less than 1 month
• February 2, 2025

For Weight Loss (Obesity/Overweight) "Flu-like symptoms, nausea, discomfort after eating anything. Broth has been my go-to. Very fatigued. Hoping week 2 will be better. Today is day 7. No appetite, no energy. There's not an option for maybe. One week isn’t enough time to give recommendations."

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• Tim...
• Taken for 1 to 6 months
• July 27, 2024

For Weight Loss (Obesity/Overweight) "Severe nausea, horrid vomiting and diarrhea after 7.5 mg dose - did okay with 2.5 and 5 mg doses - there should be more warnings with the higher doses as this was severe. Higher doses should be reviewed further for safety reasons."

• kan...
• Taken for 1 to 6 months
• December 21, 2024

For Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."

• Ano...
• Taken for 6 months to 1 year
• May 8, 2025

For Weight Loss (Obesity/Overweight) "I started taking Zepbound on July 1, 2024, after much research and many discussions with my primary care provider. My insurance did not cover the cost and, at that time, it was difficult to get access to some of the other weight loss drugs. I was able to get Zepbound at my local Walmart Pharmacy and decided to go for it in spite of the cost. At the beginning of my weight loss journey, I was 74 years old, 5'5" and 190 lbs. I started at the lowest dose, 2.5 mg, and began losing weight right away. The only side effect I experienced was slight nausea for a day or so after each injection. It also lowered my blood pressure and I was able to stop taking blood pressure medication. I never exceeded the 7.5 mg dose and am still using it sporadically (probably not the proper way to go about it). I was able to go from 190 lbs. down to 135 lbs. in 9 months."

• Mrs...
• Taken for 6 months to 1 year
• October 8, 2024

For Weight Loss (Obesity/Overweight) "Zepbound made weight loss easy. I have lost 40-50 pounds on it. Very little side effects outside of a little nausea occasionally. It’s so easy to use with the prefilled injector. I am now maintaining, and my doctor is happy with my weight. I’m so excited, I haven’t been this thin in 30 years! The only downside for me is the cost. It’s quite expensive even with the coupon. I’m not sure how much longer I can keep paying at this price."

• Anonymous
• Taken for less than 1 month
• November 29, 2024

For Weight Loss (Obesity/Overweight) "First dose 2.5 today, and already my appetite is none. I only ate a very small portion plate and drank nothing but water. It wasn't until I tried to have my daily cup of coffee when I felt very nauseated after only a few steps. Day 1, and I'm here to say I know it's going to work out (I'm hoping I can build my coffee/frappe tolerance back up, I LOVE my coffee)."