Zepbound and Nausea: What Users Say (Page 2)

• del...
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 6 months. I'm down 48 pounds. I ride a recumbent bike 25 minutes a day. My symptoms have been varied but mostly feel like morning sickness. Usually the 2nd day after the injection. Due to insurance, I do 3 months on each 2.5, 5, and on the 3rd week of 7.5. This one hit me worst, nauseous for 3 days now."

• del...
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 6 months. I'm down 48 pounds. I ride a recumbent bike 25 minutes a day. My symptoms have been varied but mostly feel like morning sickness. Usually the 2nd day after the injection. Due to insurance, I do 3 months on each 2.5, 5, and on the 3rd week of 7.5. This one hit me worst, nauseous for 3 days now."

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

For Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• Jus...
• Taken for less than 1 month
• December 28, 2024

For Weight Loss (Obesity/Overweight) "After my second 2.5 shot, the side effect symptoms are too much for me to handle. I’ve barely kept any food down except for a day and a half before my second shot. I can’t find a way to prevent acute nausea, and the vomiting is now making me weak. I knew there would be side effects, but for me, this medication doesn’t work for my body. I chose to discontinue the medication and will work with my doctor to see what other options may work for me. I have been unable to participate in family and home life, feeling trapped between being so sick I can’t leave my bed and spending a lot of time vomiting or feeling like I will if I try to move or drink water. I hoped this would be the tool to help me on a healthier path, and it’s not the right one for me, but I can see how it would possibly help others if they aren’t affected by side effects."

• Anonymous
• Taken for less than 1 month
• November 29, 2024

For Weight Loss (Obesity/Overweight) "First dose 2.5 today, and already my appetite is none. I only ate a very small portion plate and drank nothing but water. It wasn't until I tried to have my daily cup of coffee when I felt very nauseated after only a few steps. Day 1, and I'm here to say I know it's going to work out (I'm hoping I can build my coffee/frappe tolerance back up, I LOVE my coffee)."

• kel...
• Taken for 1 to 6 months
• March 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 45-year-old female starting weight 243... I just took my fifth shot a few minutes ago, and I have lost a total of 26 lb since my first shot. Food noise is completely gone, and I find myself not able to eat anything until the day before my shot. I do drink a lot of water and have no cravings for sweets like I used to. I have done moderate exercise in the evening and tried to force myself to eat some source of protein throughout the day. I also take women's one-a-day gummies and I feel fantastic! The very first shot I took, the first few days I felt horrible, like I had the flu and had been hit by a bus. Since then, no side effects except for very mild nausea, which I take promethazine to help, and it does wonders. My sleeping patterns have gotten better, and my energy has increased. It states for my age and height at 5'9, I should weigh 167. I honestly feel like I would look very sickly if I got that small, so my goal is basically just to fit in my pants from last summer, lol."

• Mrs...
• Taken for 6 months to 1 year
• October 8, 2024

For Weight Loss (Obesity/Overweight) "Zepbound made weight loss easy. I have lost 40-50 pounds on it. Very little side effects outside of a little nausea occasionally. It’s so easy to use with the prefilled injector. I am now maintaining, and my doctor is happy with my weight. I’m so excited, I haven’t been this thin in 30 years! The only downside for me is the cost. It’s quite expensive even with the coupon. I’m not sure how much longer I can keep paying at this price."

• Anonymous
• Taken for 1 to 6 months
• January 12, 2025

For Weight Loss (Obesity/Overweight) "I am a 49-year-old female. Started on 2.5 mg of Zepbound at 201. Lost some weight quickly and got to 191, then stopped. Second month, they bumped me to 5 mg. I only got sick once. It was nausea. I started losing again. Got down to 185. Then, for reasons I can’t explain, I gained 2 lbs despite walking and tracking food. On my 3rd shot, I was very lethargic for a whole weekend after the shot. I have no energy, and I am taking nothing else. I hope it goes away soon and I start losing again. It’s not a magic bullet. You have to track your food and exercise too (which is hard with lethargy)."

• Ant...
• Taken for less than 1 month
• September 22, 2024

For Weight Loss (Obesity/Overweight) "I started on a low dosage (0.25 mg/weekly) two weeks ago. It actually decreased the appetite without any side effects. I am exercising due to an increase in energy. I actually eat one meal a day, I only eat until I am full. I tried to eat more but got very nauseous. At the end of two weeks, I have lost 30 lbs. The exercise allows me to keep my muscle mass. It's great to be able to move more easily. One side effect I noticed also was increased focus in my thought patterns. It is a blessing for that. Multi-tasking is made simpler."

• Day...
• Taken for less than 1 month
• February 2, 2025

For Weight Loss (Obesity/Overweight) "Flu-like symptoms, nausea, discomfort after eating anything. Broth has been my go-to. Very fatigued. Hoping week 2 will be better. Today is day 7. No appetite, no energy. There's not an option for maybe. One week isn’t enough time to give recommendations."

• Hav...
• Taken for 1 to 6 months
• November 4, 2024

For Weight Loss (Obesity/Overweight) "I am only on 5 mg so far at 6 weeks from the start. Have lost 6-7 pounds already. Minor times of queasiness, and very infrequent. Appetite way down. So far, so good... I have pre-diabetes, insulin resistance, 2 heart conditions, and obesity (after a lifetime of being skinny but now can't lose), and my insurance STILL won't cover it! Costing me $500 a month with a copay card, which is outrageous, but I have to do this for my health and longevity."

• Mom...
• Taken for 1 to 6 months
• November 19, 2024

For Weight Loss (Obesity/Overweight) "I have had great success with Zepbound, currently on 15 mg. Been on it for 6 months, 67 lbs down. Went from a size 20 pants to a 12. I have had some nausea and vomiting. It’s easy to use. I’m squeamish when it comes to shots, so for the first 2 months, my husband had to inject me. I got used to it and can now do it on my own. I feel so much better about myself and so much healthier."

• KJa...
• Taken for 1 to 6 months
• December 27, 2024

For Weight Loss (Obesity/Overweight) "Fantastic! I have never felt better! Lost 14 lbs in 1 1/2 months minimal side effects a little nausea here and there. Nothing crazy, truly a miracle drug for weight loss, the bonus is inflammation in general is better, and I am hoping to get off my BP meds soon!"

• Anonymous
• Taken for 1 to 6 months
• January 20, 2025

For Weight Loss (Obesity/Overweight) "I am a 48-year-old female and have been on this for 6 weeks. I am down 9.2 lbs and haven't had a lot of side effects. With the dose increase to 5 mg, I noticed intermittent nausea, but nothing that prevents me from daily tasks or from taking the next shot. I am rarely hungry and get full very quickly. The shot doesn't really hurt, but I do bruise at the site. Weight loss isn't super fast, which is good because I don't want to have a lot of loose skin."

• Ang...
• Taken for 6 months to 1 year
• February 27, 2025

For Weight Loss (Obesity/Overweight) "I started Zepbound in August 2024. I initially weighed 255 lbs. I have since lost 110 lbs! I went from a size 20 to a 10! It is still very unreal to me. I am now on 15 mg and still feel great. I drink a protein shake in the morning and a small portion for dinner. The only side effect is nausea."

• Tim...
• Taken for 1 to 6 months
• July 27, 2024

For Weight Loss (Obesity/Overweight) "Severe nausea, horrid vomiting and diarrhea after 7.5 mg dose - did okay with 2.5 and 5 mg doses - there should be more warnings with the higher doses as this was severe. Higher doses should be reviewed further for safety reasons."

• kan...
• Taken for 1 to 6 months
• December 21, 2024

For Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."

• get...
• Taken for 1 to 6 months
• June 4, 2024

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for almost 3 months now. I've been at 2.5 the whole time as we are struggling to get any higher doses from back order. I have lost over 20 pounds already. My first shot, my side effects weren't horrible, but I also deal with nausea daily. I also had really bad pain in my upper back, neck, and shoulders like I had whiplash, but that was gone after 48 hours and was nowhere near as bad the 2nd shot. And then nothing after that. This past week though, I've been waking up starving, like I haven't eaten in days. I normally eat dinner around 5:30ish and have a small snack around 8ish, and I haven't had this before. The only other thing I've noticed and just read it could be a side effect is my hands have been super itchy, like I'm having an allergic reaction to something, which I've been thinking that's what's going on. But overall, my side effects have been very minimal, and the benefits majorly outweigh them."

• Lyn...
• Taken for 1 to 6 months
• December 20, 2024

For Weight Loss (Obesity/Overweight) "I am happy with the results so far. I have lost 29 lbs in 13 weeks. My goal is 75 lb weight loss. My appetite is far less, and my cravings for sugar have much improved. I have had some constipation and 1 or 2 episodes of nausea but did not vomit. You have to drink water! I started on 2.5 mg and was increased to 5 mg. I'm worried to go to a higher dose due to potential increased side effects, as I have a history of kidney issues. However, since I started the medicine, my Hga1c is normal and lipid panel perfect."

• Deb...
• Taken for 1 to 2 years
• December 20, 2024

For Weight Loss (Obesity/Overweight) "Worked great, however, I experienced nausea/dry heaves the 1st and 2nd day after injection and intermittent nausea throughout the week before the next injection. I've lost 20% of my body weight. I believe this medication needs to be taken forever, or all the weight will return."

• agm...
• Taken for 1 to 6 months
• December 18, 2024

For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 16 weeks. I have lost 23 lb. I am a 6'3" 74-year-old man. I wanted a kick start to get to my goal, which I am at. Except for three weeks at 5 mg, I have been on 2.5 and am now after a brief go at 5 mg. My experience has been generally acceptable, but nausea and fatigue are a real challenge. No vomiting or diarrhea. I have had some acid reflux. The key has been to eat good clean food and stay away from fried or greasy. I have reduced my alcohol intake, but they are empty calories, and why do it? It just makes it tougher. The reason I drink some is usually social, but I have found it easier to abstain than I expected. Here's the deal: I think people lose weight on these drugs because they don't want to get sick and choose to behave and stay at a calorie deficit, and bingo, the math kicks in. It's not rocket science. I have taken a week off while on an overseas trip. Again, I didn't want to get sick. I am about to take another week off."

• 123...
• Taken for 1 to 6 months
• September 16, 2024

For Weight Loss (Obesity/Overweight) "I began this treatment in April. It is now mid-September. I have lost 20 pounds. It is very easy to use, which is a big deal for those who have a needle phobia. In the beginning, I had very few side effects. After going to the 7.5 mg dose, I started to experience constipation and nausea. To combat this, I began a small fiber intake routine and requested Zofran from my doctor. Both are very effective for those side effects. I am now on a 12.5 mg dose and doing well. I feel I am close to a maintenance dose. This medication was quite effective. I am a small person, menopausal, and struggled with losing weight. Losing 20 lbs for my size is a very big deal. Through this process, I have learned better eating habits, keeping my portions small to maintain a healthy weight and continuing my exercise routine even if I am not losing weight. All in all, this was a win-win for me."

• dfx...
• Taken for less than 1 month
• January 12, 2025

For Weight Loss (Obesity/Overweight) "I started May 2024 with a compounded GLP-1, which worked great (some nausea), 186lbs down to 147lbs. However, I stopped working, so I switched to trizepitide 2.5 this week. Absolutely no side effects. I've already lost a pound. Once I get below 140, I'm going to go to only 2 shots a month for maintenance. I'm doing this through a clinic. I can't say enough how great I feel. I've done every diet in the book. It's the best gift you'll give yourself ever. I pay $300 for 4 shots."

• Skm...
• Taken for less than 1 month
• July 7, 2024

For Weight Loss (Obesity/Overweight) "I've only been on it for 5 days. I had heartburn for the first few days, but that's better now. Yesterday, the fourth day, midafternoon, I started getting very cold. I'm never cold, and it’s summer, about 78 degrees outside. I don't have air conditioning. I got so cold that I had to take a hot shower. Then I had to turn on my electric blanket and lay in bed until I warmed up. I started to go back to normal temperature after an hour. I find it difficult to eat. I'm not hungry but have drunk protein shakes. I felt a little nauseous the first day but it passed. I'm hopeful it will help me. So far, my blood sugars are about the same and haven't gone down."

• jme...
• Taken for 1 to 6 months
• March 13, 2025

For Weight Loss (Obesity/Overweight) "There are pros and cons to every medication that you take. Zepbound does help with weight loss. Your appetite decreases, but you can and will have GI side effects: constipation, gas, abdominal pain with overeating, belching, and nausea. Cutting back on carbonated beverages, eating small meals, and increasing protein and fiber is key. Adding nausea medication and Gas-X helps."