Zepbound and Constipation: What Users Say (Page 3)

• dem...
• Taken for 1 to 6 months
• April 28, 2025

For Weight Loss (Obesity/Overweight) "Does everything it says. I love it, the only side effect I have is extreme constipation. I've been taking it for about 5 months and down 46 lbs, and I feel much better. I have chronic pain in my lower back, but with weight loss, it helps a little."

• Ano...
• Taken for less than 1 month
• April 26, 2025

For Weight Loss (Obesity/Overweight) "I am on my 5th week. Just started 5 mg Friday 04/25/25. I started 03/28/25 on the 2.5 mg. My second day I was nauseous, but nothing Sprite and Zofran couldn’t fix. Fast forward to today. I have been sleeping really well, inflammation is gone, my hunger and food noise is gone. Now I notice the day before my shot day I start to crave some, but I just drink my water to stay full. Also, a little minor constipation. I take a stool softener with my morning vitamins, which helps, plus water, water, water!! I am loving this medicine so far, I am down 10 lbs, which I don’t think that’s bad in 5 weeks."

• Roc...
• Taken for 6 months to 1 year
• September 26, 2024

For Weight Loss (Obesity/Overweight) "67 yr old male. Started at 270. Took approximately 5-6 months to drop down to 220. Average weight loss was about 10 pounds per month. Started at 2.5 mg (weekly) and gradually went up to 15 mg. Now that I have reached my goal, I have reduced the dosage to 10 mg every 10 days for 6 more dosages. The biggest challenge was the constipation. I finally found an herbal supplement (Dr. Schulze’s Intestinal Formula #1 on Amazon) that worked amazingly! With rapid weight loss, my blood pressure has reduced to almost borderline low. But with hydration and weight now stabilizing, it is normalizing at about 110/70. I am concerned about the potential long-term side effects that are now popping up… not sure if they are legitimate or not. But too late now. Working out consistently and eating small portions will help me to keep from bouncing back up in weight. Off Zepbound completely now…and have been able to stay near 220. Drink water! Occasional Tums were needed during the first couple of months."

• Mk6...
• Taken for 1 to 6 months
• March 10, 2025

For Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."

• jme...
• Taken for 1 to 6 months
• March 13, 2025

For Weight Loss (Obesity/Overweight) "There are pros and cons to every medication that you take. Zepbound does help with weight loss. Your appetite decreases, but you can and will have GI side effects: constipation, gas, abdominal pain with overeating, belching, and nausea. Cutting back on carbonated beverages, eating small meals, and increasing protein and fiber is key. Adding nausea medication and Gas-X helps."

• Ano...
• Taken for 1 to 6 months
• August 18, 2025

For Weight Loss (Obesity/Overweight) "I have been taking Zepbound for four months and have lost 23 lbs so far. In terms of facilitating weight loss, it is a miracle drug. I eat less without feeling hungry, and I don't think about food. But there are definite side effects-diarrhea (this is the worst-can last for days), constipation (yes, the diarrhea quickly turns to constipation), heartburn (easily controlled), and some fatigue in the first 24 hours. I was on 2.5 for 1 month, then went up to 5 (ish). For me, the worst side effects kick in at 5. I am getting the medication in a vial so I can easily adjust the dose a bit. A couple of weeks ago, I went down to 4.5, and the side effects were much less severe. I'm experimenting to see where in the 4.5 to 5 range I get a balance between weight loss and side effects that I feel comfortable with. Right now, I am still losing weight. After another 10 lbs, I will be at a healthy weight and hope I can decrease the dose to maintain weight loss and reduce side effects."

• Sta...
• Taken for 1 to 6 months
• December 7, 2024

For Weight Loss (Obesity/Overweight) "They keep upping the price, and now I can’t afford it. I lost 43 pounds. It lowered my blood pressure. Dehydration, constipation, and sulfur burps, though. I had a heart attack from the dehydration. I’ve got that managed now-drinking electrolytes. I don’t want to give up, though, but I can’t afford $680 a month."

• tri...
• Taken for 6 months to 1 year
• September 2, 2025

For Weight Loss (Obesity/Overweight) "After taking this medication since February of 2025 and currently being at a 10 mg dose, I can say I got a ton of side effects and still do. I get injection site reactions I'm told to ignore because it was swelling but now is just itchy. I get constipation and the urge to go poop even when I don't have to go. Stomach aches are killer and literally leave me lying in bed unable to move. But symptoms are worst during the weekend as I take my meds on a Friday. Leading me to be unable to make plans on Saturdays or Friday evenings. I have so far lost 35 lbs over these 7 months with minimal exercise and some healthy dieting. My goal weight is 160 and I'm currently 255 down from 290 starting weight. I'm down 10% body fat. The longer I stay on my current dose, the less I feel the intensity of the symptoms, but I also still have appetite issues. As in I'll eat, and an hour later I'll be hungry again because I was unable to fill myself earlier. Or I wake up in the middle of the night to eat."

• DAS...
• Taken for less than 1 month
• May 29, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Starting 4th week of 2.5 mg. It wears off some by the end of the week. Dr. raised it to 5 mg for the next month's prescription. I am down 10 lbs in 3 weeks. Appetite is now easy to control and say no to the food/snack crazies. Very slight constipation is the only side effect I have noticed. It does work but is not affordable for me. $350 for the 1st month was the vial and syringe and out of pocket. Easy to use. Insurance declined it. $450 for the 2nd month. I can't afford it. I have researched it and found that you can buy the tirzepatide peptides online for considerably less money. I may regret it, but I am going to try it. I have seen very high numbers of happy people who went this route."

• Boi...
• Taken for 1 to 6 months
• May 30, 2025

For Weight Loss (Obesity/Overweight) "I am a 67-year-old male. I have been taking Zepbound for 3 1/2 months now. Currently taking the 7.5 strength. I have just reached the 50 lb threshold or just under 20% of my body weight lost. The drug is not a magic potion as you still have to eat the right calorie foods, but the drug makes it much easier as I am really never very hungry and fill up quicker. My biggest struggle has been wanting to snack at night from boredom. As for side effects, I belch more, early on, I experienced some upset stomach but found if I eat a few crackers with peanut butter, I feel a lot better. I also experience some constipation, but my doctor said that was mainly due to the reduced amount of calories I am consuming. Overall, I am thrilled with the experience and results. I plan on losing another 5-10 pounds, then work on maintaining new eating habits. My doctor suggested I order some extra of the 5 strength and keep it back to take if I start sliding back into old eating habits. I plan on doing that."

• Cry...
• Taken for 6 months to 1 year
• February 21, 2025

For Weight Loss (Obesity/Overweight) "I've lost 67 lbs in 10 months. Only side effects have been some constipation and slight nausea. This has been a life changer for sure!"

• Jmd...
• Taken for 1 to 2 years
• July 11, 2024

For Weight Loss (Obesity/Overweight) "Blurriness in right eye, constipation, rapid heartbeat, lightheadedness"

• Ano...
• Taken for less than 1 month
• June 2, 2025

For Weight Loss (Obesity/Overweight) "I am 2 weeks on Zepbound, have lost 5 lbs. It curbs my appetite, no side effects except constipation. So far I am very pleased with it."

• Ano...
• Taken for 1 to 6 months
• May 31, 2025

For Weight Loss (Obesity/Overweight) "It's working moderately to curb my appetite. I have experienced a change in bowel pattern and constipation."

• Tho...
• Taken for 6 months to 1 year
• December 11, 2024

For Weight Loss (Obesity/Overweight) "Love Zepbound; in 8 months, down 40 pounds; minimal side effects, some constipation, but gone in a few weeks."

• Pat...
• Taken for 1 to 6 months
• September 21, 2024

For Weight Loss (Obesity/Overweight) "I have lost 43 lbs in less than 4 months. Works great, but I have had side effects of a drop in blood sugar, where I almost passed out, very tired, and constipation."

• Nic...
• Taken for less than 1 month
• August 25, 2024

For Weight Loss (Obesity/Overweight) "I took my second 2.5 mg shot yesterday and am down 3 pounds. The shot is easy to administer and painless. I have experienced constipation and painful hives on my neck right after taking."

• Ano...
• Taken for 1 to 6 months
• July 1, 2025

For Weight Loss (Obesity/Overweight) "Zepbound has been great. Best on the market. Weight loss is adequate. Side effect of constipation, low energy, maybe a little anxiety."

• NDH...
• Taken for 6 months to 1 year
• September 4, 2025

For Weight Loss (Obesity/Overweight) "Zepbound has really helped with food cravings and appetite. It has been almost a year since I started and I have lost 65 lbs. I had severe constipation at first but have learned to manage it now with stool softeners daily. I had tried Ozempic at first but didn't have much success on it and switched to Zepbound when my insurance covered it. Now still being on 15 mg, I do seem to have achy muscles that just don't go away and it makes it hard to sleep, so that is my only concern now. Wondering now on my treatment for long-term maintenance to keep weight off."