Tirzepatide and Fatigue: What Users Say (Page 3)

• Nyn...
• Taken for less than 1 month
• August 1, 2024

For Weight Loss (Obesity/Overweight) "I’m taking oral tirzepatide. I’ve found practically nothing on the oral route side effects. Today was day 7 of 3 mg per day x 1 month. I feel fatigued and weak often. Only having a tiny bit of nausea - no vomiting. I have no appetite and no cravings. This has been much easier, side effects, than my son who takes it subq."

• Pam...
• Taken for 1 to 6 months
• October 28, 2024

For Weight Loss (Obesity/Overweight) "I started tirzepatide injections the first week of September. I have lost 14 pounds. Started on the lowest dose of 2.5 and felt great...felt the best I have in years. Took the lowest dose for 6 weeks, then we went up to 5, and I think it's too strong because I feel the worst I have ever felt...extreme fatigue, confusion, do not want to eat anything. So dehydration and lack of food probably has a lot to do with it. But every week, a couple of days before my next injection is due, I always even start to feel bad like my body needs the injection. I'm paying $425 a month for this medication. My goal was to lose 20 to 25 pounds, and I'm very close. So I'm trying to decide if I should take it one more month but use the 2.5. Because many people say they have to take this medication for a few years. Sometimes I feel wonderful, and other times it makes me feel horrible, and I definitely don't enjoy alcohol at all anymore. Does anyone have similar experiences like I've had?"

• Cla...
• Taken for 1 to 6 months
• December 7, 2024

For Weight Loss (Obesity/Overweight) "After a terrible experience on Wegovy (including intense fatigue and eventually depression and suicidal feelings), I was scared to try another GLP-1. But after a few months, I cautiously tried tirzepatide, and I'm so glad I did. I’ve lost 35 pounds in 4 months, just 10 more to goal! And side effects have been easier. No effects on mood, a little fatigue but only for the first month. The worst side effects have been dry mouth and dry eyes at times, in the first day or two after my dose. These have been very manageable. And I have plenty of energy, and my mood feels positive and stable. I highly recommend! I get mine compounded, and I like using a syringe rather than a pen because I can titrate my dose up more slowly."

• Fat...
• Taken for less than 1 month
• April 7, 2023

Tirzepatide for Type 2 Diabetes "I am nearing the end of my 3rd week with Mounjaro 2.5 mg. The side effects in the first week were awful: heartburn, sulfur burps, nausea, and slight headache. These side effects lessened by the 5th day. The second week was a little better. The side effects were somewhat better and only lasted for 4-5 days. Fatigue crept in the second week. Now I am on Day 5 of my third week. The main side effects now are acid reflux, slight nausea, and extreme weakness and tiredness. My appetite is really suppressed on Mounjaro. I don’t get hungry at all. So far I have lost 13 lbs in 19 days. The weight loss is great, but the fatigue and weakness are really bad. I am a 63 y/o male, type 2 diabetic for 25 years, currently 252 lbs. This medicine is not for everyone, and I don’t think I will be taking another Mounjaro injection."

• dJg...
• Taken for 1 to 6 months
• May 18, 2023

Tirzepatide for Type 2 Diabetes "Began in March 2023. I have very little appetite and eat but experience lots of shakiness. At first, it caused severe belching and indigestion, especially in my upper mid/right back, but it has gone away, shakiness has increased. I still feel fatigued, hoping that will go away!"

• Ste...
• Taken for 1 to 6 months
• July 28, 2024

For Weight Loss (Obesity/Overweight) "I’ve lost about 10 pounds in probably 6 to 8 weeks. I feel okay on this drug. I have experienced some tiredness and fatigue, and some diarrhea as well, but nothing too bad. There was only one week where it was bad enough that I might rethink using it. Now it’s mild and lasts for about 2 days post-shot. Some blurry vision as well. I most likely won’t stay on this drug for the long haul."

• MEN...
• Taken for 1 to 6 months
• March 12, 2025

For Weight Loss (Obesity/Overweight) "This has helped overcome the weight loss plateau I have experienced post-menopause in a way which no other eating or exercise regimes have managed to achieve. My overall food intake has probably not reduced significantly, but it is easier to manage with fewer cravings and feeling fuller for longer. I think the metabolic effects have been key to the weight loss of slightly under 2 lb a week. Increased appetite has been apparent on day 6. I have had to increase the dose to 10 mg weekly over 9 weeks, having experienced minimal appetite suppression on 2.5 mg weekly. The main side effect has been noticeable fatigue, which I try to offset by administering the medication at nighttime. It wears off as the week progresses. Time will tell whether I will habituate to this side effect. Looser stools have been apparent in the first few days, but no other gastrointestinal symptoms. Overall, I am very pleased with the results, and the tiredness, while not desirable, is bearable given the outcome."

• can...
• Taken for less than 1 month
• July 29, 2024

Tirzepatide for Type 2 Diabetes "I started Mounjaro on July 19th, 2024. I started the medication because I was pre-diabetic, my A1C was high, and if I could lose a few pounds, it would be a plus. In my first week, I had the following side effects: nausea, loss of appetite, dry mouth, and some fatigue. I went to my doctor for a follow-up and had lost 5 pounds in my first two weeks. This was good, and I loved the weight loss. My A1C was 5.5, wonderful. Yet, I talked to my doctor about the fatigue. It had worsened to the point where my body didn't want to go up and down stairs. He suggested it was my sleep, however, my sleep habits hadn't changed. I'm planning to take Mounjaro 2.5 to see if the side effects lessen. Updates to come."

• Mar...
• Taken for less than 1 month
• September 23, 2022

"I started taking the 2.5 on 9/1 after I had begun IF on August 1. Overall, I have now lost 12 pounds over 7 weeks. My appetite is significantly reduced; my biggest concern is I’m not getting enough calories due to lack of appetite and also a restricted eating window. Since being on the medication, I have experienced constipation, diarrhea, especially on day two and three after the shot each week, general fatigue, and a generally uneasy stomach, and sometimes stomach cramps. Usually, these wear off by day five and are worse on day three and four. It is not clear to me if my weight loss is due to the fasting or the medication or both, but it does seem to be steady at 1 to 2 pounds per week as I am tracking it. I only hope that it continues to lose at this rate and does not plateau! I am ready to move up to 5 mg next week, and I’m a little nervous to experience stronger side effects. So far, I am thrilled to actually be losing weight! SW: 187. GW: 130.5’2” age 54."

• KRK...
• Taken for 1 to 6 months
• July 16, 2024

For Weight Loss (Obesity/Overweight) "I am a 63-year-old female with healthy organs in my 12th week of self-administered injections. Initial constipation but more walking, fiber daily, and Colace (stool softeners) when regularity changes helped. I do injections in abdomen (where I have the most fatty tissue) and get itching and hardness often in days following. Losing 1.6 lbs per week (20 lbs so far). Hunger greatly reduced. Doctor recommended Alka-Seltzer Gold when I was experiencing heartburn and stomach discomfort. Works great. I find that now that I am eating better, I do not suffer as much from that discomfort. I am experiencing some fatigue but generally feeling good due to lifestyle changes boosted by the lack of hunger and weight loss. Hit a plateau after I reduced the amount, and a friend recommended Collagen with peptides - amino acids. It really has helped, and now I am closer to 2 lbs per week weight loss on a lower dose. I had a total of 50+ lbs to lose, and that is still higher than my ideal weight in my youth."

• mas...
• Taken for 1 to 6 months
• August 23, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost weight in the first few weeks. Some issues with belching and diarrhea for the first several weeks, which declined over time. But then, after approximately 6 weeks, no weight loss was noted. Still eating less, so hoping that the decreased intake of calories would reduce weight. Then had COVID, so had to miss a week, stayed on original dosage, no weight loss. Then, when dosage increased after the 3rd month, symptoms returned: upset stomach and diarrhea. During the same period, slightly elevated temperature, fatigue, headaches. Lost from 240 to 218 in 4 months, so cost was $100 per pound."

• Har...
• Taken for 2 to 5 years
• January 17, 2025

"Does work to lower blood sugar/A1C. Also works to lose weight. Over long-term use, it seems to allow for slight weight increase. Side effects include loss of appetite, fatigue, burps, stomach pain, nausea, and gastroparesis. After about two months of use, I developed an extreme sensitivity to touch. My skin became very painful all over, feeling like a mild sunburn with a horrible sensation of severe chills all the time. I am trying to tolerate the chills, but it is very severe."

• Dee...
• Taken for 1 to 6 months
• May 5, 2023

Tirzepatide for Type 2 Diabetes "I started taking Mounjaro 9 weeks ago and lost 12 lbs in the first 5 days. Since then, I haven't had an insulin injection, and my blood sugar levels are good. I've been insulin-dependent for almost 20 years and overweight for just as long. I've now lost 33 lbs in 9 weeks, which is great. However, I've experienced some negative side effects, such as nausea, heartburn, dizziness, and fatigue. Despite eating what I should and drinking lots of water, I still feel nauseous and dizzy most days, which makes it difficult to exercise. I only get 2 good days out of the week where I feel like doing something besides sitting. I've only vomited once, but the feeling of needing to do so is always present on a daily basis. Since starting this medication, my weakness has increased instead of declined, which is frustrating because it limits my ability to exercise properly. Overall, while weight loss and improved blood sugar levels are positive outcomes, the negative side effects make it challenging to maintain a good quality of life."

• Flo...
• Taken for less than 1 month
• December 22, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "This medicine has made me so sick. I will never take it again. I have not eaten in over five days. I am so weak, I feel like my blood sugar is low. I am not a diabetic, I only wanted to lose a few pounds. I have been sick, nauseous, vomiting, fatigue, diarrhea. Until I got everything out of my belly, my belly felt full, even when I did not eat. Constant belching. My food does not taste good. I am miserable. I’m sure it has great benefits. My other family members took it, as for me, whom is diabetic, extremely curvy, but just wanted to lose excess belly fat. I probably should’ve just gone to the gym, exercised more, or even worn a waist trainer. To me, in my opinion, it’s not worth it."

• Jos...
• Taken for 1 to 6 months
• January 11, 2023

Tirzepatide for Type 2 Diabetes "No issues until I began the 7.5 mg dosage. I am achy, tired, very low energy for the second and third day after the shot. These side effects wear off just in time to take the next dose."

• Jul...
• Taken for 1 to 6 months
• October 22, 2024

For Weight Loss (Obesity/Overweight) "Fine, some burning tongue sensation, tiredness, fatigue."

• Rob...
• Taken for 6 months to 1 year
• August 1, 2024

Tirzepatide for Type 2 Diabetes "Has been effective in controlling sugar level. I'm at 7.5 now. Side effects I've had and have are severe headaches, bloating, nausea, low energy. Take it every Friday. Sometimes hard to get."

• Law...
• Taken for 1 to 6 months
• June 8, 2023

Tirzepatide for Type 2 Diabetes "Has been good. Some constipation. Some fatigue. Good weight loss and hunger control."

• Oti...
• Taken for less than 1 month
• April 20, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost 5 lbs the first week. Lots of diarrhea. Feeling fatigue fairly often. Rarely feel hungry. Easy to go most of the day without eating."

• Rho...
• Taken for 6 months to 1 year
• March 25, 2023

Tirzepatide for Type 2 Diabetes "Fatigue that has not gone away after several months of use. Nausea for the first 24-36 hours after injection. Constipation that goes away 2-4 days after injection."