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Semaglutide and Nausea: What Users Say (Page 4)

Brand names: Ozempic, Rybelsus, Wegovy

Reviews for Semaglutide

Commonly mentioned side effects
  • Mal...
  • Taken for 1 to 6 months
  • August 21, 2024

For Weight Loss (Obesity/Overweight) "I'm 60 years old, started taking Wegovy for weight loss, high blood pressure, high cholesterol. I’ve been on the medication now for 10 weeks. My starting weight was 296. Currently, I weigh 266, and my numbers are great. The cons are I only feel good 4 days a week. The first 3 days after the injection are tough: nausea, headaches. But as far as I’m concerned, it works great. I’m not hungry at all. I feel much better. Another added bonus for me was I was a heavy drinker. On this medication, I have no desire to drink at all. I went from 5 cases a week to absolutely nothing. I don’t miss it at all. Miracle drug."

10 / 10
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  • Lin...
  • Taken for 1 to 6 months
  • September 16, 2021

For Cardiovascular Risk Reduction "70 years old, not diabetic but obese at 170 lbs, 5’2” tall female. Started weekly on 4/29/2021 and as of 9/16/2021 I am at 140 lbs. Cannot eat as much as I used to or I get nauseous. Slow loss, about 7-8 lbs a month. Plateau every so often and then lose 3 lbs immediately. Extremely happy with results."

10 / 10
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  • Hap...
  • Taken for 1 to 6 months
  • April 2, 2022

For Weight Loss (Obesity/Overweight) "I'm in my 9th week, now at 1 mg. I learned very quickly to eat small portions and slowly because I would feel way too full if I tried eating as much as I used to. I tried a couple of weeks ago to eat a whole Popeye's chicken sandwich for lunch. I felt nauseous all day afterward. Half a sandwich is enough. I'm down 10%+ of my weight already. It is very easy. I am just not hungry. The hard part is changing how much to put on my plate. Now that I'm used to taking less, I'm totally fine and don't even think about hunger, cravings, anything. Wow. So happy."

9 / 10
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Frequently asked questions

  • Tom...
  • Taken for 6 months to 1 year
  • April 13, 2023

For Weight Loss (Obesity/Overweight) "Started Wegovy in March 2022 with a goal of losing 50-75 pounds. I ended up losing a total of 85 pounds in about 11 months. I felt great upon taking the Wegovy. Only had mild headaches and mild stomach discomfort. I was not tired, I actually felt energized. However, by December, the nausea had reared its ugly head. I took Zofran, and it helped. I was able to stick it out with the nausea until February, at which time I stopped taking it. I could no longer live with the nausea. Since I stopped taking it, I have continued to suffer nausea, vomiting, and stomach pain. My doctor and I are still trying to find the source of this continuing issue. I love the weight loss, and I love Wegovy!"

7 / 10
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  • Bla...
  • Taken for 6 months to 1 year
  • August 13, 2022

For Weight Loss (Obesity/Overweight) "I started Wegovy in Jan. 2022. I didn’t feel much effect for two months, although I lost a few pounds. Starting in the third month, it kicked in. The weight loss isn’t fast, about 4 to 6 lbs a month, which I feel is healthy. I’ve lost 27 pounds. Like others, I had some queasiness, especially in the first few months, but it was quickly resolved with Zofran and has mostly disappeared. I now feel full after smaller portions than before and notice I eat about half as much as previously and feel perfectly satisfied. I’ve read that you tend to gain weight back if you go off the drug and that many doctors feel you should be on it forever, as with other chronic conditions. I hope that’s not the case, as I don’t like the idea of being on any drug forever. In fact, I’m hoping I can also go off blood pressure meds eventually. My goal is to lose another 30 lbs, which now feels entirely doable. My excellent insurance covers it at $25 a month."

9 / 10
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  • Cin...
  • July 12, 2019

For Type 2 Diabetes "Well, so far and this is my 3rd week (I'm taking it for weight loss only) and I'm a little sick in my stomach, but no throwing up or bad gas. Fingers crossed, I hope I don't. Some of these side effects sound awful. I've lost about 2 pounds a week so far, and if this keeps up, I am going all the way with this. I take 0.25 so far. My doctor wanted me to try because I've lost 275 pounds all by myself, and I've been at a standstill. He wants me to get over this hump, so I'm trying this and so far so good. I hope it continues to be good for me. I hate it's not for some... And by the way, I've never had diabetes. So I'm taking it only for weight issues. I'm 50, and it's taken me 4 years to lose the 275lb."

8 / 10
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  • GEF...
  • Taken for 1 to 6 months
  • January 9, 2022

For Weight Loss (Obesity/Overweight) "I’ve been using Wegovy for 12 weeks. I’m up to 0.50 and staying here. Tried 1.0 and it was too strong. Felt nauseous and experienced painful stomach cramps with 1.0. I have reached my goal weight. I lost 35 pounds and I’m very happy with the process and results. The only negative is, I’m on thyroid medication and noticed hot flashes and heart palpitations I didn’t experience before. I had my levels checked and they are way off! Consulting with my doctor. Not sure if I’ll continue Wegovy."

8 / 10
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More FAQ

  • Sos...
  • Taken for 1 to 6 months
  • March 7, 2023

"I was nervous taking this given previous reviews. My doctor started me on the 3 mg tablet. Initially, I felt a bit nauseous, but I was told to wait an hour to eat. The nausea went away. Immediately by the 3rd day, I could tell I wasn’t as hungry as before. I don’t look for snacks, I don’t overeat my dinner, and I get full faster. I'm on my second month and now up to 14 mg. The boost of energy I’ve had has helped me get back to exercising 3-4 days a week and walking almost every night for an hour with the dogs. I started 1/19 and weighed 183. It’s 3/7 and I weigh 158. It’s not all the pill, but the pill certainly boosted my energy, which in turn helped me get back on my feet to move around more. The best part is my insurance covers it completely. I feel like a new me."

8 / 10
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  • Too...
  • March 21, 2023

For Weight Loss (Obesity/Overweight) "My first dose made me sick as a dog two days after the injection. Nausea, felt like I could vomit, and kept swallowing over and over again. Cold chills, it was awful! I do not plan to continue. No pain, no gain. I’ll get my loss the old-fashioned way with proper diet and exercise. Never again want to feel this way on Ozempic."

1 / 10
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  • JAO...
  • Taken for 1 to 6 months
  • June 14, 2023

For Weight Loss (Obesity/Overweight) "I had been on this drug for 4 months. Typical escalation dose until month 4, I stayed on the 1 mg. The side effects were rough since increasing to 1 mg. So much nausea, worsened reflux, constipation, bloating, burping, and indigestion. I vomited once, but there were a few times I almost did. In the last few weeks, I noticed hair loss. Noticed skin tags that I have never had...like 3 grew since the med. Weird. Oh, and I had serious issues with certain smells. I had to change out the hand soaps in my house 5 times. If I smell rubbing alcohol, I am instantly nauseous. Just looking at the Wegovy box before injecting would make me dizzy and nauseous. So weird. Difficult to eat healthy on this med due to side effects, and only able to tolerate simple carbs, low-fat diet. Also hard to work out when feeling so nauseous...so didn't think it was contributing to my health. Has not really contributed to weight loss, and appetite is almost the same as before med."

1 / 10
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  • Tan...
  • Taken for 1 to 6 months
  • May 12, 2022

For Cardiovascular Risk Reduction "I have been taking Ozempic since March 12, 2022. I started at the .025 dose for 4 weeks. I had a little nausea, but nothing serious, and some constipation. I have now been on the .050 dose and have very little appetite, and no other symptoms have remained other than occasional constipation. I have to remind myself at times to eat. I have more energy than I have had in years and feel so much better in my clothes. Since March, I have lost 25 lbs. This has been a life changer for me as I feel so much better. I am still 45 pounds from my goal weight, but this drug has definitely helped me. I give the shot in my thighs, as I have read many comments on here to do so for fewer symptoms, and I believe that is why I have done so well."

10 / 10
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  • Fif...
  • Taken for less than 1 month
  • August 29, 2021

For Type 2 Diabetes "On week 4 now, honestly, the first 2 weeks were a nightmare. Doctors don’t tell you to stay away from fatty foods and not to overeat. If they did, I wouldn’t have had the most horrible sulfur burps that made my eyes water, projectile vomiting, diarrhea, and stomach pain, not to mention constant nausea even during the night. I finally figured out not to eat too much and to avoid fatty foods completely! This was a game changer, and now I’m doing okay. I've lost 21 pounds so far, which is mad, but mostly because in 2 weeks I’ve eaten probably 4000 calories. I’m back to wanting to eat again but have to control myself or face the terrible consequences. Blood sugars are all over the place, as you can imagine, however, insulin sensitivity is way better. It just takes time to get used to. Hope this helps."

6 / 10
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  • Anonymous
  • Taken for 6 months to 1 year
  • May 8, 2023

For Weight Loss (Obesity/Overweight) "I was prescribed Ozempic for weight loss in Nov 2022. I started on 0.25 mg for one month. I found it slightly suppressed my appetite, and the side effects I had were awful heartburn, constipation, and sulfur burps. Sometimes I felt nauseous. I decided to stick with it anyway and increased to 0.5 mg after one month. The symptoms were the same but added in fatigue. A month later, I bumped up to 0.75, and the burps, fatigue, and heartburn subsided. I went to 1 mg two months later, and all symptoms disappeared. I started at 192 lbs on Nov 15th, and as of May 1st, I weigh 152 lbs. I found my sugar cravings disappeared once I started taking 1 mg. Up until then, I still craved sugary foods. I lost all interest in greasy food (fries, anything deep-fried, etc.) from 0.5 mg and up. I personally love Ozempic. The side effects at the beginning were worth it for me, but from the sounds of it, mine weren’t that bad. I have never once thrown up."

10 / 10
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  • Nao...
  • Taken for 1 to 2 years
  • April 9, 2025

For Type 2 Diabetes "My A1C had gone up as high as 8.0, and my doctor kept adding medications to my arsenal of drugs to control my diabetes. I was taking so many drugs but was getting terrible side effects, including kidney stones, liver enzymes over 600, diarrhea, nausea, and finally, I was hospitalized and taken off all my drugs, but then my diabetes was out of control. Finally, my GI specialist recommended starting with Ozempic .5, and that's when everything started to change. At first, I didn't see much change in my weight loss, so my doctor raised it to 1mm. It was then that I saw my A1C go down to 7.2, and I had lost 10 pounds without trying. Now I have been taking Ozempic for over a year, and my A1C is down to 6.7, and I dropped 20 pounds. I don't have any side effects unless I overeat, which I avoid. If I overeat, I get an uncomfortable feeling in my stomach, but within a short period, it subsides. I wish my mother would have had the ability to get Ozempic 10 years ago, maybe she'd be alive today."

10 / 10
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  • Ros...
  • Taken for 1 to 6 months
  • February 25, 2020

For Type 2 Diabetes "This medicine did what it was supposed to. It lowered my A1C, but it also almost killed me off. I was so sick. I had to stop it. The worst medicine ever! I felt like I was reaching the end of my life. I couldn't do anything, couldn't eat, couldn't even get out of bed. I lost a lot of weight! My stomach hurt, my side hurt, my back hurt. I started feeling better once I quit taking it! I will never take it again! It almost felt like it was poisoning my entire body!"

1 / 10
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  • Mar...
  • Taken for 6 months to 1 year
  • March 16, 2025

For Weight Loss (Obesity/Overweight) "I've been on Wegovy since September 2024. To date, I've lost about 30 pounds. I've had very mild side effects, a little nausea occasionally, particularly the first few days after increasing dosage. I have ongoing GI issues that have made it worse a few times in the last 6 months, but nothing too serious. I was nervous about injecting myself weekly, but it has been relatively easy and painless for me. I'm finally getting clear signals to stop eating when I'm full. I used to think eating a full plate of pasta was no big deal, and now I eat less pasta in general, but if I do, I aim for no more than half, and usually it's closer to a third of a plate with the addition of a small side of non-starchy vegetables. I've been seeing a nutritionist too, and they've been so helpful in making lifelong diet changes. Right before I started taking Wegovy, I looked at the reviews on here and it nearly scared me away. I'm so glad it didn't. Wegovy has been such a helpful tool in my health journey."

10 / 10
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  • Pat...
  • July 19, 2019

For Type 2 Diabetes "Started taking Ozempic for pre-diabetes and insulin resistance. This is the first medication I've ever taken for diabetes. A1c was 5.7. I increased the dose quickly at the doctor's recommendation if little to no side effects occurred. First dose 0.25 in the office. Second 0.5 a week later. Third dose at 1.0 a week after that. Only side effect I have is mild nausea. Appetite has disappeared, and I eat only when hungry and much smaller portions. Serious bloating when I eat too much, which is a great deterrent. Been on the medication for 4 weeks overall, 2 weeks at 1.0, weight dropped from 305 lbs. to 295 lbs. Still a little lethargic, but I was very lethargic before starting the medication. I feel like this medicine is a game changer for me. I love not thinking about food all of the time, only eating when hungry and not for pleasure, and losing weight. Will retest A1c in 2 months. Hopefully, the weight loss continues, and I caught the A1c level before it turns into full-blown diabetes."

10 / 10
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  • Mac...
  • Taken for 1 to 6 months
  • September 14, 2019

"I am pre-diabetic with high blood pressure, high triglycerides, and high cholesterol. I’ve taken Ozempic for 3 1/2 months to help me lose weight. My weight loss is 32 lbs. I am never hungry, and when I eat, my tummy gets full very quickly. Because I’m not hungry, I have used this time to learn the art of healthy eating. No fad diets or keto. My blood pressure is now normal, and I am off BP pills. My triglycerides dropped 150 points. I have had no side effects other than constipation. I now drink 3 liters of water each day and eat insoluble fiber to control it. My husband is diabetic and has been on it for 6 months. He experienced side effects such as nausea and dizzy spells, but it lasted around 3 months, and he no longer has them. His A1C was 9.5 before Ozempic and is now 6.7."

9 / 10
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  • Los...
  • November 10, 2019

For Type 2 Diabetes "I am a 70-year-old type 2 diabetic and was taking one Metformin 500 ER for the past year or so. My A1C was 11, and it dropped to 5.6 by changing my diet and taking the Metformin. My doctor wanted me to try Ozempic to help me lose weight and possibly eliminate the Metformin. The side effects were terrible right from the start. Nausea and diarrhea, no vomiting, just nausea. I started at 0.25 and am now up to 1.0. My appetite is gone completely. I have no desire to eat at all. When I do eat, I get full almost immediately. I have gone from 228 lb down to 202 lb in the six weeks I have been taking Ozempic. I'm thrilled with the weight loss, and the nausea and diarrhea have improved. However, I have almost stopped peeing. I go in the morning, then go all day into the evening without going. Since I suffer from incontinence, it's good, but I am worried that it might be damaging my kidneys. I hope I don't have to stop taking it, at least till I lose another 50 pounds or so."

7 / 10
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  • Lau...
  • Taken for 1 to 6 months
  • April 1, 2020

For Type 2 Diabetes "I have been prescribed Ozempic for weight loss secondary to type 2. I got nauseated with some loss of appetite at 0.25 mg dosage and adapted to it over a month. Lost 9 lbs in that month. I increased to 0.5 mg last Friday (it is Tuesday), and I am miserable. Non-stop nausea, burping, some pain in the stomach, constipated. I feel miserable. I am worried about the stomach pain being pancreatitis starting, so I am increasing my water. I haven't eaten in two days. I will not continue with this drug as I think this just cannot be a good thing to do to one's body."

3 / 10
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  • Val...
  • Taken for less than 1 month
  • February 14, 2020

For Type 2 Diabetes "I’m a nurse. I started this med and unfortunately the nausea, gastritis, dizziness, and headache continuing into week 4 is simply not worth it. I can’t lay in bed and be miserable, which is what this does to me. At first, I actually thought I had a GI Bug. If there is any other choice, do not put yourself through this."

5 / 10
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  • Sen...
  • August 29, 2019

For Type 2 Diabetes "I've been taking Ozempic for about 2 months to lower my Diabetes 2. It's been great, my numbers were 200 to 300, they are now 100-134. My A1c was 9.8, it is now 6.1, and I've lost 12 lbs and still losing. I'm also taking Synjardy XR, a combination of (Metformin & Jardiance), my numbers are great. I eat extremely less on the Ozempic. My only side effect has been an occasional headache, but nausea was brutal. I was getting very nauseated after eating and taking Synjardy XR until I heard about ZOFRAN. Let me just say, if you have nausea and are taking Metformin with Ozempic, PLEASE ask your doctor for a prescription of ZOFRAN (I got the generic ONDANSETRON 4mg). I take it 20 minutes after I eat and have taken my metformin. I NO LONGER get nausea. Zofran will definitely help with nausea if you're feeling sick. You'll thank me later."

10 / 10
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  • 188...
  • Taken for 1 to 6 months
  • May 17, 2023

For Weight Loss (Obesity/Overweight) "Started Wegovy 3 months ago using the gradual phase-up method. From 0.25 mg dose for 4 weeks to 0.50 mg dose for 4 weeks, then 1.0 mg dose for 4 weeks. During the initial phase, I experienced mild nausea and some stomach irritation. With each increase, the symptoms got worse until finally, at the full 1.0 mg dose, I was so sick I thought I had stomach flu for 2 weeks continuously. The belching was horrible. The nausea caused uncontrollable vomiting, and I had frequent diarrhea. After 3 months, I lost 12 pounds and felt horrible every day. I've now reduced the dose to 0.5 mg but still suffer from nausea and stomach upset. I might cut back again, but I'm thinking I will quit. The way I feel all the time is horrible! I'm thinking I lost weight because of all the vomiting. Not recommended."

1 / 10
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  • Jan...
  • Taken for 6 months to 1 year
  • May 26, 2021

For Type 2 Diabetes "I started Ozempic in July 2020. The first few weeks, I had slight nausea. Now, 10 months in, I’ve lost 50 lbs - from 210 lbs to 158 lbs, and my sugar levels, if anything, are on the low side. I’ve just stopped taking my Metformin as they were dropping too much. I didn’t even make it to the 1 mg, stopping at the 0.5 mg. If you can last the first 4 weeks, it’s amazing. The only side effect I have is a little constipation, which I control with PEG when needed. It has changed my life! I feel like a brand new woman!"

10 / 10
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  • Onw...
  • Taken for 1 to 6 months
  • July 18, 2021

For Type 2 Diabetes "I am male (early 50s). Blood glucose was already regulated with metformin, diet, and exercise (100 to 150), but I wanted to quit metformin because of its side effects (diarrhea). I was put on 0.50 mg/wk and warned that nausea from Ozempic was a common side effect. I had no idea! Week 1/Week 2: I couldn't smell food without getting queasy. I choked down lots of soup just to get 1200 cal/day (often falling short). Week 3/Week 4 got slightly better. Week 5: I have my appetite back. I feel full, so I eat smaller meals. My weight loss is atypical: 203 lbs to 183 lbs in five weeks, combined with exercise (1 hr/4x wk stationary bike/treadmill). Blood glucose is now between 90 and 120, with occasional dips and peaks. I would only recommend this drug to those who have very high glucose levels, are morbidly obese, fiercely stubborn, and/or desperate. But it works. Good luck."

8 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.