Semaglutide and Fatigue: What Users Say (Page 5)

• BJB...
• Taken for 1 to 6 months
• May 20, 2023

For Weight Loss (Obesity/Overweight) "I started using semaglutide for weight loss at the lowest dose, and each 4 weeks raised the dosage. I did not lose a single pound in all that time. I am a yoga instructor and practice 4 times per week. I became so severely constipated that I ended up in the ER. I battled with very severe fatigue, weakness, at times overly hungry, blurry vision, and a feeling of just being 'out of it.' I feel like I lost 3 months of my life. After taking my last dose 9 days ago, I’m still having bouts of diarrhea, stomach pain, and headaches. It was not worth it at all for me."

• tyn...
• Taken for 1 to 6 months
• January 12, 2023

For Weight Loss (Obesity/Overweight) "I have lost significant weight. I have not experienced the vomiting and stomach aches, nausea, but I have experienced extreme fatigue, muscle weakness, and soreness. I'm coming off the medication because of the muscle soreness."

• Txg...
• Taken for 1 to 6 months
• January 4, 2023

Semaglutide for Type 2 Diabetes "A1c crept up to 6.9. Started Rybelsus for a 30-day intro with fairly vague side effects of light nausea, constipation, and reduced appetite. Increased to regular 7 dosage and immediately side effects were extreme and awful. Constant significant nausea, abdominal discomfort, significant constipation, low energy. Almost no desire to eat, and if I did eat, even very little food caused even more discomfort that escalated. Food just sat in my stomach feeling heavy and sour. Heartburn and gas were constant. After just 5 days of a larger dose, I stopped the medication but with lingering side effects. After being off the drug for two days, I sustained immense abdominal pain like I have NEVER experienced that finally culminated in strange diarrhea. Too many intense and questionable side effects for me. Weight loss - by not being able to eat - not worth the escalating horrible side effects for me. I'll never take this drug again."

• S-L...
• Taken for 6 months to 1 year
• February 2, 2023

Semaglutide for Type 2 Diabetes "Major nausea ebbs and flows. Extremely bad fatigue off and on. More along the lines of exhaustion. No weight loss. I’m on a pretty high dose, 1.5, and am only about 15 lbs overweight. Diabetes type 2 most of my life, so this is a great drug. Hopefully, the next generation of these drugs will have fewer side effects for some of us. The nausea and fatigue are pretty overwhelming some days. A1c has improved, so I will stay on until something better comes along."

• Tko...
• Taken for 1 to 6 months
• May 23, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I started approx. 3/29 and will begin my third step up to 1 mg this week. I have lost 23 lbs in 8 weeks. Very happy about that. My appetite is reduced. I can sometimes skip dinner because, after a light lunch and breakfast, I am not hungry. I have experienced fatigue, nausea, and constipation. However, if I eat something like an apple with peanut butter, that helps with the constipation. So far, these side effects are not bad enough for me to discontinue. I would like to feel better, but I am hoping it will improve. Fatigue is the worst for me because I also have another autoimmune disease that causes extreme tiredness. I am taking a multivitamin and see my doctor in a week, and I will discuss negative side effects. Right now, the benefits of losing weight are worth it."

• Moo...
• May 20, 2019

For Type 2 Diabetes "On my 5th week of semaglutide, and my dose went from 0.25 mg to 0.50 mg as prescribed. I was taken aback by the first 3-4 days on 0.50 mg. After 4 weeks on 0.25 mg semaglutide with no significant side effects, but at the 0.50 mg dose, I developed strong nausea, weakness, and fatigue, and a feeling as if I was fighting the flu. My mobility and energy literally were quite impaired. By the end of day 4, I've noticed a slow, gradual improvement, and I was able to go out for some groceries. (Gravol for the nausea helped.) I'm hoping that I will continue to adapt to this medication because I really like its effectiveness for my diabetes. Since starting 5 weeks ago, my glucose dropped from 10+ to a new average of 7.0. I've also lost weight, my weight loss is already 10 lbs+, my stomach is flattening, and I can see other positive changes. This is the perfect med for me as it addresses my diabetes and is promoting noticeable weight loss. Overall, I am very pleased after 5 weeks on semaglutide."

• dru...
• Taken for 1 to 6 months
• January 28, 2019

For Type 2 Diabetes "In a drug study for weight loss. I am losing about 1-2 pounds a week consistently for the past 5 months (20 pounds so far). Side effects are worst 1-2 days after the weekly injection. Fatigue, nausea, gas... You have to eat plenty of fiber to not be constipated. I have also experienced vivid dreams off and on since starting the drug. I am torn between tolerating the side effects and losing the weight. I will try to stay in the study until I have reached an acceptable weight for my size and age. I would highly suggest it for the obese. Good luck!"

• Daw...
• Taken for 1 to 6 months
• May 17, 2022

For Weight Loss (Obesity/Overweight) "I was placed on semaglutide for weight loss. I began with 0.25 mg once weekly week one, increased to 0.5 mg week two, at that point, I began to experience intermittent nausea. This was bearable, and I was still able to maintain my calories. I was down 8 lbs at the beginning of week three. Week three, I increased to 0.75 mg and had a lot of fatigue. I felt like I was a walking zombie for three days. I realized at that time that I was not eating enough calories and made a continuous effort to meet my protein goal, and the fatigue went away. I have now been on the medication for nine weeks. I have kept the dose at 0.75 mg (the suggested max dose is 2.5 mg), and I am losing 2-3 lbs a week. I feel great, and all the side effects have subsided. I am reading that they peak and subside around four weeks. The initial titration period can be rough, but this was so worth it for me as I had weight loss resistance for years. I will have my lipid panel drawn next week and hope for a reduction there as well."

• Try...
• Taken for 1 to 6 months
• March 4, 2019

For Type 2 Diabetes "I was part of a drug study to lose weight. I lost 20 pounds in 6 months, the drug reduced my appetite significantly! Now, the weight loss has stabilized, I have not lost or gained in 5 weeks. But the side effects are getting too bothersome to continue. I have fatigue and am sick to my stomach for 2 days after the weekly injections. Lately, I have been having vivid dreams that are disturbing and wake me up. I also notice I am irritable and not as happy-go-lucky as my usual self. These side effects are no longer acceptable to me, I want my sleep, good mood, and 7 days a week of feeling good! I am grateful for the weight loss, but I am not comfortable continuing this drug with these side effects."

• Jan...
• Taken for less than 1 month
• June 22, 2025

For Weight Loss (Obesity/Overweight) "On second week. So far lost 4 lbs, so very happy with that. Not sure if this is the cause, but extremely fatigued. Just want to sleep and do sleep a lot during the day. No more get-up-and-go. Getting nothing done for just don't have it anymore. Going to give it a little more time to see if body adjusts, second injection today. If it doesn't, will have to get off for can't live like this. There isn't a life when all I want to do is sleep."

• Rob...
• Taken for 1 to 6 months
• March 1, 2025

Semaglutide "I have been taking Ozempic for five months, and I have lost 35 pounds. That’s the good part. I continue to have very bad fatigue, and when I upped my dose, I find myself nauseous and vomiting. I’m gonna continue taking it for a little while longer to reach my goal. So far, it has been worth it for me."

• Kat...
• Taken for 1 to 2 years
• July 3, 2025

Semaglutide "I’ve been on Wegovy for just over a year. At first, I experienced heartburn and a little bit of nausea and fatigue. I only threw up once. I’m adjusted to it now, and it’s keeping the weight I lost off, which was 60 pounds. I used to get migraines the day after injection, sometimes a couple of days in a row. I have found that if I take the injection earlier in the day around lunchtime and I also eat around the time I take the injection, I have fewer headaches. Please remember, you should avoid greasy foods because that causes the nausea and the heartburn, although I do enjoy an occasional hamburger. I am starting to notice a vision issue in one eye, but I don’t know if it’s related. I’m getting ready to see an ophthalmologist. I’m also in my 50s and knew already that I have the beginnings of cataracts. At first, injections cause constipation, eating better causes them to become regular for me."

• Cor...
• Taken for 1 to 6 months
• June 9, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "Last night, I had my first injection of 1 mg strength (week 3). I have gastrointestinal issues of bloating, eructation, diarrhea, and abdominal pain, LUQ 3-4/10 pain. It feels like a stomach virus, chills, but afebrile. Fatigue and anorexia. Only lost 5 lbs, but think it’s due to significantly reduced food intake."

• Zen...
• Taken for 1 to 6 months
• April 10, 2023

For Weight Loss (Obesity/Overweight) "Super constipated. Super fatigued. Weight loss after 3 months = 8%. Currently at 1 mg dosage level. Had to start taking Linzess to combat constipation. The loss of energy seems severe. I'm happy with weight loss, but hate side effects!!!"

• Zen...
• Taken for 1 to 6 months
• April 10, 2023

For Weight Loss (Obesity/Overweight) "Super constipated. Super fatigued. Weight loss after 3 months = 8%. Currently at 1 mg dosage level. Had to start taking Linzess to combat constipation. The loss of energy seems severe. I'm happy with weight loss, but hate side effects!!!"

• jud...
• Taken for 1 to 6 months
• March 15, 2025

Semaglutide for Cardiovascular Risk Reduction "2-3 days per week I suffer from poor sleep and fatigue accordingly. Trying to get to sleep is bad, with body noises making it impossible. Also, constant burping with gas buildup, farting at night is awful, watery eyes. The other 4 days is fine. The days are not in a row and often vary each week. My rating of the medicine would vary on different days, bad days, bad rating."

• Joe...
• Taken for 1 to 6 months
• October 17, 2024

Semaglutide for Type 2 Diabetes "Terrible side effects: lower stomach pain, sleeping too much, and fatigue. I've only been taking for two months at 0.25 mg and 0.5 mg each month. I hope for better results when I increase to 1 mg next week..."

• NEW...
• Taken for 1 to 6 months
• March 7, 2025

Semaglutide for Type 2 Diabetes "I started out on 0.25 once a week and then 0.5 for two more weeks. I am now at 1.0. I experienced a little nausea in the beginning, but it has subsided. I find it interesting that I don't crave salty foods and actually turn them down. I am craving salads, which I find interesting. I've lost 7 pounds in 5 weeks, and now with the increase, about a pound every two days. The best part is I am on Metformin and Janumet, with a daily blood sugar averaging 340. With the addition of Ozempic, my average blood sugar has been at 122. My A1C has dropped from 11 to 9, all in a very short time. I suffered heart failure last year, and my refraction rate is now back to normal at 55 percent. I am now experiencing some fatigue, but that could just be my body adjusting to all the meds on board. I feel I now have a brighter future ahead, especially with the normal sugar level, and am planning to do a lot of outdoor activities this summer. I've also gone back to water aerobics and have my life back."

• Ano...
• Taken for 6 months to 1 year
• June 13, 2025

For Type 2 Diabetes "has improved my diabetic lab work to normal (remission). I have been able to lower my blood pressure medication in half and also my cholesterol medication. I have been able to completely stop my metformin. In total, I have lost 40 pounds. But the first 6 months were awful - all of the GI symptoms all the time. Along with hair loss, fatigue, dehydration. Most of these symptoms have significantly decreased as I am 9 months out now. Now I have developed a tremor in my hands. It is not going away and is getting worse. Terrified I will gain back the weight if I stop. I have frozen my dose (advice of my doctor) even though it was not the maximum dose recommended. I had hoped to take semaglutide for at least 2 years but am not sure I can tolerate these symptoms."

• Sun...
• Taken for 1 to 6 months
• January 2, 2019

For Type 2 Diabetes "I was using this in a weight loss study. Started injecting 0.25 in October 2018 and increased to 0.50 within weeks. It’s now 1/2/19 and my GI doctor is sending my test results to the doctor in charge of the study, along with a note that he is recommending I stop. This medication has allowed me to lose weight, 20 lbs in fact, but it’s because I am starving. I have developed gastroparesis and can barely eat. Dark circles under my eyes, sore bones and muscles, and extreme fatigue among other things. I’ve spent money and my own insurance out of pocket because the study is denying this is a known side effect. I am now on 2 strong antibiotics to kill bad bacteria and avoid infection from the delay in stomach emptying. I wish this on no one and have learned it is not worth being an experiment. Really wish there was a good forum to discuss with others. Had high hopes since FDA approved for diabetes."

• Tre...
• Taken for 1 to 6 months
• March 28, 2024

For Weight Loss (Obesity/Overweight) "Loss of 25 pounds over 3 months. Sugar levels stabilized; was able to discontinue metformin. Significant decrease in joint pain due to reduced inflammation. Less brain fog. Some nausea and fatigue, however."

• Ric...
• Taken for 1 to 6 months
• June 25, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "So far, so good. Six weeks on. Constipation's been an issue. Definitely has cut my appetite down, and I lost my taste for my weekend beer and have a glass of wine or two. Everything else has been fun. Little fatigue I’ve noticed, but hopefully I continue to lose weight."

• Not...
• Taken for 1 to 6 months
• October 3, 2024

Semaglutide for Type 2 Diabetes "Still early, so this may change as time goes on. I am currently taking 0.5, increasing after the next dose. In the beginning, I had stomach pain and sickness, but these symptoms died down after I learned to eat more protein and not to skip meals. Another thing that bothered me at first was fatigue. I could not keep my eyes open. I slept a lot, and if I had something to do that day, it took everything in me just to make it through the day. These symptoms also subsided after I stopped skipping meals. I would be lying if I told you my choice to start taking Ozempic wasn't to help me lose weight. That was one of the major selling factors for me. Anyone who knows anything about diabetes knows you do pack on the weight, and any help shedding those unnecessary pounds is a plus. I can't say I have lost a lot of weight yet, but with what little time I have been on Ozempic, I can see a decent decrease in my weight. As for my diabetes, my A1C will tell in time."

• kem...
• Taken for 1 to 6 months
• October 3, 2024

Semaglutide for Type 2 Diabetes "My doctor switched my medication from automatic insulin to Ozempic, taken once a week, along with daily long-acting insulin injections. I lost my appetite, my mouth feels tasteless, and no food appeals to me, so I have to force myself to eat. My blood sugar levels have been unpredictable, fluctuating between highs of 250 and lows of 60. One minute it’s very low, and after eating, it shoots up, then drops again. I decided to stop the long-acting insulin last Sunday, at the start of the fourth week when my Ozempic dosage was increased from 0.25 to 0.5. Since then, things have slightly improved—my blood sugar isn’t running too low anymore, but it is still high. During this time, I’ve also developed severe heartburn, sleeplessness (only a few hours of sleep at night), and sluggishness, among other symptoms. I contacted my doctor yesterday."

• ros...
• Taken for 1 to 6 months
• September 12, 2024

For Weight Loss (Obesity/Overweight) "Light constipation for the first 3 days. I started to eat mostly a protein and vegetable diet with lots of water daily. I noticed a small amount of satiety the first evening. 0.25 mg for 4 weeks, 0.5 mg for 8 weeks. For the first 6 weeks, I struggled with fatigue and insomnia pretty badly. I had a little nausea. Still overeating occasionally, once or twice a week, pretty badly. Then I started the 1 mg doses. This is where I am now. Pretty good food satiety, finally, I am experiencing the cessation of most food noises. If this satiety continues, I will try to stay on this 1 mg dose. 14 weeks in and 23 lb weight loss. Started at 5’1” 192 lb - now 170 lb. I’m really working hard on maintaining a healthy diet and moderate exercise. I’ve been struggling with a food addiction my whole life. This has the potential to be life-changing."