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Roflumilast topical and Itching: What Users Say

Brand names: Zoryve, Zoryve Foam

Itching: mentioned by 6 users (11.3%)

Based on user experiences from 53 Roflumilast topical reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

itching 11.3%
diarrhea 5.7%
headaches 5.7%

Reviews for Roflumilast topical

Commonly mentioned side effects
  • Ace...
  • Taken for 1 to 6 months
  • August 26, 2024

For Plaque Psoriasis "I have been taking this in addition to my biologic treatment, Skyrizi. I don't think it's any better or any worse than other topical medications. I have been taking Clobetasol for years with similar results. For me, it keeps the itch down, but is not curative of the plaques."

6 / 10
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  • Anonymous
  • Taken for less than 1 month
  • October 28, 2024

"Just got a sample from the doctor, as the doctor says it is new and pretty unaffordable for most seniors. It's great, went on well, no itching or burning, as my skin on ankles and lower feet is pretty raw and scaly, and long-term, nothing has worked and little to improve my overall condition."

10 / 10
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  • Sik...
  • Taken for less than 1 month
  • November 4, 2024

For Plaque Psoriasis "Started using my Zoryve about a week ago for plaque psoriasis... Behind my ears, it helps with the itching and redness, however, it still has a continuous buildup/flakes. The first of this cream, thought it would get rid of the entire psoriasis... OVERNIGHT."

8 / 10
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  • Ano...
  • Taken for 1 to 6 months
  • June 26, 2025

For Plaque Psoriasis "Palmoplantar psoriasis - I only apply this cream on hands, heels, and elbows. My insurance covers it (first it was denied, but my doctor insisted, and it was approved). I pay $0. It started working within weeks and greatly improved the miserable condition of cracked heels and fingers. Unfortunately, if I stop and skip days, it returns. The middle of my palms do not heal completely. And it's been months at this point, so I'm not sure Zoryve treats this condition, maybe it just makes it tolerable. Side effects: itchy skin, and I noticed urinary tract related changes like pinkish color of urine sometimes. I don't know what happens if I stop using it - will psoriasis return with a vengeance?"

9 / 10
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  • Lin...
  • Taken for less than 1 month
  • August 19, 2024

"Just started using this cream and foam. Hopefully it will help! Can't do steroids! First application and itching has really calmed down."

8 / 10
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  • Eil...
  • Taken for 1 to 6 months
  • May 17, 2023

"Noticeably less plaque within the first week. Continued use resulted in cessation of itch. By week 3, eczema sites were reduced to pink skin."

8 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.