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User Reviews for Pioglitazone to treat Diabetes, Type 2

Also known as: Actos

Pioglitazone has an average rating of 4.8 out of 10 from a total of 37 ratings for the treatment of Diabetes, Type 2. 27% of those users who reviewed Pioglitazone reported a positive effect, while 46% reported a negative effect.

Pioglitazone Rating Summary

4.8/10 average rating

37 ratings from 40 user reviews.

Compare all 158 medications used in the treatment of Diabetes, Type 2.

10
22%
9
3%
8
3%
7
3%
6
14%
5
5%
4
5%
3
8%
2
11%
1
27%

Reviews for Pioglitazone

Dee · Taken for 1 to 6 months March 28, 2021

Actos (pioglitazone): “I was on Actos a couple of months. My sugar levels improved just slightly but I also put on about 12 pounds within that time frame. I had a bit of hair loss and had terrible swelling of my feet and legs which I didn’t normally have an issue with. I was not thrilled about starting this to begin with because of the awful side effects ( A BIG list of them) but my doctor wanted me to try it! Too many serious side effects for me! I just had her switch me to Glipizide. Too many meds to try without going through all of that and being miserable. Please research it if you are thinking about trying it!”

1 / 10
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Gg · Taken for 1 to 6 months February 1, 2021

Actos (pioglitazone): “I took this medicine for around a month and a half and it did nothing for my sugar levels. It caused a 15 pound weight gain. I stopped taking it after reading the serious side effects it can cause. Why take something that is going to make me worse off than I already am?”

1 / 10
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Gamera1969 January 29, 2020

“I have been on Actos 30mg for over a year but 3 months ago I started having severe daytime drowsiness. I went to see a sleep doctor about this and they recommended some that I follow a strict sleep schedule and make a few medication changes. I called the sleep people and demanded another sleep study in case my C-PAP machine needed to be adjusted. They adjusted it but 2 weeks later there was no improvement. So they had me wear an Atigraphy Watch for a week to see how much I slept among many other things to keep track of. They called today 1/29/2020 and said it must be a drug that I am taking. I told them that there isn't any new medications I am taking. Almost all of them I have been on for years. But as I was napping in the afternoon as usual it crossed my mind that there are 2 drugs that I have not been taking for several years. Actos & Jardiance. So I looked up the side-effects of these drugs and BAM! there it is for Actos....Extreme Fatigue. I am NOT taking this drug.”

6 / 10
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Tbeckley548 July 3, 2013

Actos (pioglitazone): “I am 66 years old and have been on Actos for over five years, taking 45mg. Lately I have experienced shortness of breath swelling of ankles and feet, weight gain, anemia and fatique. My primary physician ordered an echo-cardiogram and a lung function test and they both indicated my heart and lungs were fine. Dr. attributed the issues to my taking Actos and immediately took me off the medication. He replaced it with Tradjenta (5mg) and asked me to monitor my blood sugar levels three times a day during the transition. I have been off Actos for 24 hours and feel better already. I know that sounds impossible but I believe it may have been the cause of my recent health issues.”

6 / 10
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Doodleman · Taken for 2 to 5 years October 13, 2019

Actos (pioglitazone): “Took Actos prescribed by VA doctor, now because of this, I have got stage 4 bladder cancer. It took 4 years and 36 treatments to get in remission. Actos is banned in some countries except USA. Yet the VA still prescribe it. Someone must be getting kickbacks, wither the FDA or VA in my opinion.”

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epiphany4z January 25, 2011

Actos (pioglitazone): “Took 30 mg Actos for 8 or so months was very happy with it at first. It did lower my numbers but...I had so many bad side effects. Weight gain, chronic fatigue, swelling, urgent need to urinate, watery eyes, and pain. I could barley get up my steps. I stopped taking this medicine myself and I feel as if I have been raised from the dead. ”

1 / 10
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Vicky · Taken for 2 to 5 years September 2, 2018

Actos (pioglitazone): “I was on this pill for about 2 years gained about 40 pounds and also had really bad muscle pain. I took myself off of it so far have lost close too 20 pounds and muscle are feeling so much better. These pills the doctors give me freak me out. All the side effects are so bad.”

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Plowdeep · Taken for 5 to 10 years September 30, 2015

Actos (pioglitazone): “I have been taking Actos for 5 years. Recently the cardiologist diagnosed me with heart failure. My EF is 30%. 2 weeks ago I stopped taking Actos and my fasting blood test is 125 the same reading as when I was taking Actos.”

2 / 10
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nosugar4me October 16, 2010

Actos (pioglitazone): “I've been taking 30 mg of Actos per day for 3 years. In that time I have gained 55 lbs and I have had problems with my feet, ankles and lower legs swelling. I would have stopped taking this medication a long time ago but I was blaming the water retention and weight gain on menopause. Now that I stopped taking Actos I lost 4 lbs in 2 days.”

2 / 10
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Rose C. January 14, 2015

Actos (pioglitazone): “When I was initially diagnosed, my Dr. put me on Metformin, which just ripped my stomach to bits. He prescribed Actos in October, and I had really good luck with it until around Christmastime - I started having HORRIBLE sinus problems and nosebleeds. We dropped to a 15 mg dose, but still no change with the sinus issues. I went off it all together and all the symptoms disappeared. It was never our long term plan to keep me on Actos because of the cardiac implications, but it did the job we needed it to do; I went from fasting 400-504 BG readings down to fasting readings of 110-115.”

7 / 10
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Anonymous October 24, 2011

Actos (pioglitazone): “Actos has worked well for me for 10 years and now comes FDA with another cancer scare. Anything can induce cancer and the scientific data on Actos causing cancer does not have that much credibility with me.”

10 / 10
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Kat R · Taken for 1 to 6 months February 15, 2016

Actos (pioglitazone): “I have been taking actos since Nov and had great results at first and now it seems like it it doesn't work at all even after taking an additional pill with evening meals. Blood sugar readings are the same with or without it”

2 / 10
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CWA September 15, 2009

Actos (pioglitazone): “I was on Actos for nine months. At first it controlled my blood sugar well, but then I started to have blood sugar lows in the 40s, gained 28 pounds eating 1200 calories a day, swelling of feet and lower legs, and finally short term memory loss. Got a second opinion on the drug. Stopped it and all symptoms ceased within one week. I have lost 12 of the 28 pounds. I have lost 50 before this drug. I am now on glipizide and metformin. My blood sugar is a little higher but I feel so much better. I took a difficult college class and got an A, so I know my brain is functioning better. ”

1 / 10
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shurgood June 26, 2007

Actos (pioglitazone): “I started on actos about six weeks ago. I was given a free supply by my doctor, but no mention of any side affects. When the free supply ran out I filled the prescription. A list of serious side affects was included with the prescription. One mentioned swelling of the feet and ankles which is was what I was experiencing. I stopped taking this drug and now the swelling is going down slowly.”

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Anonymous March 4, 2008

Actos (pioglitazone): “I was taking 30 mg of Actos daily, and for the two weeks after I seriously started taking it, I had dull throbbing headaches to full blown migraines non-stop! About 2 weeks into taking it, I developed a dull pain in my kidney area. Thinking it was a kidney infection, I went to my Dr's. We found out that it was muscle soreness...one of the common side effects. I also gained weight. As soon as I stopped taking it, the headaches stopped,and the muscle pain is going away.”

3 / 10
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grahamr July 17, 2007

Actos (pioglitazone): “I started taking Actos 45 about 8 weeks ago. It lowered my sugar dramatically. I take it with glyburide/metformin. My sugar is running from 57 to 65 when I wake. This causes lightheadedness and blurred vision. The other side effects are greatly enlarged legs and feet. The water retention is alarming. My doctor lowered it to Actos 30. See what happens. This may not be the drug for me.”

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Anonymous October 29, 2011

Actos (pioglitazone): “I have been taking Actos 15mg for about a month now, no ill effects like I feared. I keep watch for edema and so far nothing. My insurance would not cover the Januvia I used to be on- and for me Actos works better. My numbers are normal now (90-140) and they were high normal on the Januvia. I would recommend this medicine to people who cannot afford the DDP-4 (Januvia class) drugs.”

9 / 10
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Anonymous June 9, 2010

Actos (pioglitazone): “Have been on Actos for almost a year, gained 24 pounds and have swelling in hands and feet and are retaining a lot of water in my thighs. My sugar levels are good. My doctor lowered my dosage from 30 mg to 15 mg but refused to take me off. Will get a second opinion because the side effects are too much.”

4 / 10
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Jimmy the Cricket · Taken for 6 months to 1 year August 13, 2019

“Took Pioglitazone for about 8 months or so, all was OK, my numbers were down for a while, but now I have gained weight, the numbers stay the same, I feel tired, dizzy, I was swelling from the waist down all the way to my feet to the point that I had a hard time getting into my clothes. I contacted the Dr and he reduced the dosage, but I felt the same the fatigue continued and so the swelling. I was not myself anymore, I decided to stop taking the pioglitazone on my own for about three weeks now and I am back in action, my numbers have not changed, I feel alive again, the swelling has gone down a bit, but the fatigue is gone. I will give my doctor one more chance to find an alternative medication, if none available will look to change to another doctor for sure. 1.0”

6 / 10
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bjrouse May 5, 2009

Actos (pioglitazone): “My Doctor started me on 30 mg when I was diagnosed 13 months ago. I jog, hike, and lift weights and was experiencing lows quite frequently so my doctor and I decided to reduce my dosage to 15 mg. The lower dosage works great for me. My lows are more predictable and are not as frequent. Off setting the lows temporarily is easily accomplished with food or juice. I have not experienced any swelling, nor any side effects that I am aware of other than the occasional lows (80s). I think this is due to the low dosage, regular exercise, my diuretics for high blood pressure and watching what I eat carefully. I am very satisfied thus far with Actos.”

10 / 10
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Nikitagirl June 17, 2010

Actos (pioglitazone): “My doctor put me on Actos 6 months ago. I noticed swelling of legs and feet. The joints in my arms are aching daily. I also had a 23 pound weight gain and noticed headaches. But it has brought my sugar levels back under control. I didn't know about the particular side effects. I am going to talk to my doctor about them and see if I can get a replacement.”

6 / 10
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J0hn_Lloyd · Taken for 1 to 6 months July 24, 2015

Actos (pioglitazone): “Actos 15mg Metformin 850 mg works for me for almost 3 months now. Before I have fbs of 185 and 225 after meal. Now, almost everyday I prick, I got around 90 and 100 before and after meal. Better take these meds before breakfast.”

10 / 10
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nicamar September 13, 2009

Actos (pioglitazone): “I been taken Actos 30mg since a year from now and my sugar lever went down but not enough, then my doctor changed it to 45mg. Is great for my sugar level but my legs, feet and ankle can not handle it ss too much swelling.”

5 / 10
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dhannebohn December 31, 2008

Actos (pioglitazone): “I took Actos 45 mg for about 2 years an had swelling in my legs and muscle pain as side effects. Actos did bring my HbA1C down to 5.9 so it was great for blood sugar control but the side effects just got to be to much to handle. I tried switching to glucophage during that time but could not tolerate it due to stomach problems. My doctor is now switching me to glipizide and we'll see how that goes.”

3 / 10
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Anonymous June 4, 2009

Actos (pioglitazone): “Been using Actos 15 mg with Metformin (2x1000) for several years now. Most of the side effects listed have not been a factor for me. I do have some swelling of the lower legs and ankles, but that was pre-existing. I have not noticed any difference since I have been on this medication.”

8 / 10
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Jerry · Taken for less than 1 month June 3, 2019

“Started taking 15mg of this drug once a day. No effects for first 12 days. On Day 14 I started having shortness of breath and chest tightness. Gradually got worse over the next several days until just a quick walk across the room would leave me stopping to gasp for breath. Stopped taking the drug after reading these reviews on day 21. It's now day 28 and I continue to have the same symptoms.”

1 / 10
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pickle2353 August 18, 2008

Actos (pioglitazone): “I have been taking this drug for one month and I feel so much better and my sugar is in control. I noticed that my digestive problems mostly disappeared when I started taking this drug. My IBS is much better. The swelling and bloating in my abdomen has reduced greatly. So far I have not had any noticeable side effects. I take 15mg daily.”

10 / 10
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JennyJen · Taken for 1 to 6 months January 10, 2019

“Lowered blood glucose (BG) and A1C but the side effects couldn't be tolerated. Leg and abdominal edema was considerable resulting in weight gain, pelvic floor pressure with less bladder control. Went off for a couple months then tried again at lower dose. Leg edema not as noticeable but again had me thinking I had a UTI which I again did not, cultured to confirm. I was on the med for 5 weeks each time and problems worsened, which after that long I would expect them to decrease. This med is definitely not for me.”

4 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.