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Olanzapine for Borderline Personality Disorder User Reviews

Brand names: Zyprexa, Zyprexa Zydis, Zyprexa Relprevv, Zyprexa Intramuscular

Rating: 7.6

Olanzapine has an average rating of 7.6 out of 10 from a total of 40 reviews for the off-label treatment of borderline personality disorder. 70% of reviewers reported a positive experience, while 13% reported a negative experience.

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Reviews for Olanzapine

Commonly mentioned side effects
  • Hop...
  • Taken for 2 to 5 years
  • July 14, 2023

"This medication works wonders for me. It helps a lot with my mood, anxiety, and a lot of my psychotic symptoms of BPD. I have high anxiety, so this definitely works. I am finally able to live my life because of it and even got my college degree."

10 / 10
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29 Report
  • Zoe...
  • April 18, 2019

"I have borderline personality disorder, 35 years of age, diagnosed in 2016, but didn't really understand it until 2018 and was in denial and drinking for 6 years. I'm on venlafaxine (Effexor), and it was the first drug where my depression was lifted, but I was still looking at trying to leave the house. Come 2019, stopped drinking, started smoking weed, had a hypomanic and hallucination episode while in the hospital, and a good psychiatrist gave me olanzapine, and it changed my life, this was the drug I've been looking for (I used to be anti-drugs until things got so bad I couldn't work). He gave it to me for a manic episode because he said I wasn't acting like myself. Only on olanzapine 3 days, and I noticed a difference only in one day. I had to get the medicine special ordered and took it after a week out of the hospital. So I saw the difference in that one week, nothing triggered me, wasn't obsessively thinking and racing mind, no depression, no rage or anger. Life-changing!"

9 / 10
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52 Report
  • ZZY...
  • Taken for 10 years or more
  • January 29, 2017

"I was in a study of this medication. Half got it, and the other half got placebo. The dose was increased to 20 mg at bedtime. I got dramatically better in every area. My husband and parents were thrilled because I had previously attempted suicide and had to be hospitalized. When the study was halfway over, all of us got Zyprexa, and the half that must have been on placebo, because they didn't get ANY better, all had results like I did. At the end of the trial, I stopped it because I had gained 6 pounds in 12 weeks. A week off it, my husband said I had to get back on it since I had been so bad. This is 11 years later, and my weight is back to normal, still on the medication."

10 / 10
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52 Report

Frequently asked questions

  • Ano...
  • Taken for 1 to 6 months
  • February 16, 2015

"Very helpful for insomnia and stress, and my Borderline Personality Disorder, Obsessive Compulsive Disorder, and the severe depression and anxiety I've had all my life. Plus, no weight gain! I love this one out of all I've tried and would recommend it to anyone else who suffers from these afflictions - God bless and be well."

10 / 10
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58 Report
  • BPD...
  • Taken for less than 1 month
  • December 13, 2014

"Zyprexa (along with Prozac) worked miracles for me right away. No mood swings, no irritability/anger, no depression, no suicidal thoughts, no impulsivity, I don't feel nearly as cynical, very little emptiness/boredom. Energy is up during the day, Zyprexa helps me sleep. Slight lightheadedness, but nothing troubling. I have my life back."

10 / 10
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54 Report

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  • KWR...
  • Taken for less than 1 month
  • May 29, 2016

"I have suffered from BPD and depression since early adulthood. I have been seeking help for 30+ years. I've been on all kinds of medicine, but it wasn't until Zyprexa was added to my antidepressant that I found complete relief of my horribly unstable mood and suicidal thoughts. I felt relief from the second day of use. I never thought that I would feel normal and happy. Amazing! No more rage, no more depressive episodes, less compulsive thoughts, my mood is so even. So happy to have stumbled upon a medicine that works."

10 / 10
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42 Report
  • Viv...
  • Taken for 1 to 6 months
  • July 22, 2022

"This drug completely removed my agitation/irritability episodes without making me feel like a zombie. I feel so peaceful, and I still can feel, just not to a painful degree. I highly recommend. No weight gain (2.5 mg)."

10 / 10
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17 Report
  • Dav...
  • March 13, 2017

"This medicine is very powerful and is easily the best medicine that I've taken for borderline personality disorder. If you go down the list of symptoms for BPD, this medicine basically takes care of all of them, with two major side effects: sleepiness and weight gain. I have tried almost all of the SSRIs and SNRIs, Wellbutrin, Saphris, and Abilify, and nothing works as good or as quickly as Zyprexa."

9 / 10
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31 Report
  • Tor...
  • Taken for 1 to 6 months
  • February 28, 2018

"I love Olanzapine. It was a life changer. However, I've put on 10+ pounds since I started taking it in about September 2017. Do not smoke or drink often, though (more than once a week), because I find when I do, the effects of the medication aren't as substantial. I struggle with alcoholism and find it hard to stay alcohol-free. So, because I don't listen to myself, the pills aren't working as well. Usually, my thoughts are clear, my anxiety is minimal, and I'm able to LIVE. But lately, I'm crippled emotionally. Stay away from alcohol and drugs while on Olanzapine."

9 / 10
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27 Report
  • Anonymous
  • Taken for 2 to 5 years
  • May 16, 2017

"At the age of 12, I was forced to take olanzapine at 15 mg for 3 years until I stopped the medication cold turkey against psychiatrists' orders. I slept on average 14 hours a day, and my emotional state was flatlined for the duration of those 3 years. I experienced several side effects that impacted my life in more ways than I can explain: constant shaking, excessive weight gain, and so many more. I remember accidentally taking a double dose and suffering the most intense pain I have ever experienced in my life to this day. This is the worst drug I have ever had the misfortune to take, and I think they need to stop giving it to children and adolescents immediately."

1 / 10
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33 Report
  • Jim...
  • Taken for less than 1 month
  • June 22, 2015

"I have tried so many medications over the years to treat depression and BPD. My doctor prescribed this medication, and I know this sounds silly, but I could feel its effects the second day. Getting back to my old self. No emotional outbursts of anger. On the road to recovery!!"

10 / 10
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34 Report
  • BBa...
  • Taken for less than 1 month
  • May 7, 2019

"I’m close to being 35 years old, and this is the first time I’ve felt a resemblance of myself returning since my teen years! I’m on a 2.5 mg dose of olanzapine, I have borderline personality disorder. It really works, and the only negative side effect thus far is restless legs at night. That can be easily dealt with. It’s a small price to pay for finally finding some relief."

8 / 10
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21 Report
  • Cam...
  • Taken for less than 1 month
  • October 16, 2018

"I have been taking olanzapine for a little under a month now, and I have noticed slight effects, and it doesn’t completely stop the BPD, but it does help getting yourself back to being you, which is something I struggle with immensely! I take 5mg of olanzapine in the morning alongside 100mg of sertraline. At night, I have 10mg of olanzapine and 10mg of melatonin an hour before my bed, and I quickly get sleepy. For me, olanzapine has made slight changes with my moods and personality, but I need to wait a few more weeks to start noticing the full effects. Thanks for your time reading my review and opinion."

6 / 10
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23 Report
  • BPD...
  • February 24, 2016

"I have had great improvements with my depression and mood swings with Zyprexa and Prozac. This seems to go like peanut butter and jelly. I can't say for sure it's the meds, but my suicidal thoughts are pretty much gone completely, and I thought that would never happen!!! Thank God!!!!"

9 / 10
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28 Report
  • cha...
  • Taken for less than 1 month
  • July 24, 2019

"10 mg Olanzapine has reduced my anxiety and given me enough energy and motivation to clean my house. Before I took this medication, I spent most days curled up in a ball, unable to deal with anything. Overall, this has been a wonderful thing for me. It made me really sleepy initially (I slept through alarms and was late for work a few times) and definitely gives you the munchies. I have gained 2 kilos in 2 weeks."

8 / 10
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18 Report
  • gt1...
  • Taken for less than 1 month
  • January 25, 2022

"I've struggled for years to get a proper diagnosis and the correct medication. I was diagnosed with Borderline Personality Disorder (BPD) 3 weeks ago and started on Zyprexa 5 mg, recently upped to 10 mg, and it has changed my life. While I'm slightly groggy and lightheaded some days, the benefits of this medication are well worth it. Zyprexa gave me my life back and took away my anxiety. I highly recommend."

10 / 10
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11 Report
  • ric...
  • Taken for 1 to 6 months
  • September 8, 2017

"Best antipsychotic I've tried. On 5mg, also on 225mg Venlafaxine for C-PTSD (helps with depression & anxiety). Best combo I've had to date, but doesn't make me energetic, but alleviates the C-PTSD, BPD, and IBS, so it's a winner."

8 / 10
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18 Report
  • Mis...
  • Taken for 1 to 6 months
  • August 30, 2019

"On the olanzapine for bipolar and borderline. There was no difference in my condition, except it destroyed my liver and affected my appetite so much that I gained 30 kg in about a month. I was never obese in my whole life until then, and I am still, although that was almost 3 years ago. The liver got healthy very fast, as it always had been until the biggest destroyer of my life - olanzapine."

1 / 10
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18 Report
  • mm3...
  • Taken for 1 to 6 months
  • November 3, 2017

"2.5 mgs of olanzapine a day, BPD-ADHD-GAD. Able to cope with mood swings better as if observing them from a distance. Takes the edge off agitation and have that all-important regular sleep cycle. I can't stop eating but haven't gained a lot of weight. Symptoms are still present but easier to deal with."

8 / 10
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18 Report
  • Lou...
  • Taken for 6 months to 1 year
  • May 11, 2019

"I have been on olanzapine for 9 months. I had psychosis and was started on it. I am back on a 10 mg dose - it was lowered to 7.5 mg recently because of weight gain during that time. I was incredibly anxious, agitated, had insomnia, began seeing things, was tearful, and my anger increased. I have only been back on the 10 mg for a couple of days, but I feel less agitated, am still seeing things, but it is lessening. I am less jumpy. I am less tearful, and my sleep is improving. I plan on staying at this dose because it did help me in the past before the lowered dose. The key to keeping a stable weight is healthy eating and exercise, like walking, I think. Olanzapine really helps, so for me, weight gain is something I'll try and deal with. It is said the longer one is on it, your appetite stabilizes. I don't want to feel like I did before, so I am sticking with it. I was diagnosed with EUPD (emotionally unstable personality disorder) 10 years ago. I am close to 40 years old."

8 / 10
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14 Report
  • Yog...
  • Taken for less than 1 month
  • March 10, 2016

Olanzapine "Worst, make me feel extremely dizzy and about to pass out any time soon... I even fall off on my bathroom floor because I'm unable to stand still. I take it at night, but the effects are still there when I wake up in the morning!"

1 / 10
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24 Report
  • Cal...
  • Taken for 1 to 6 months
  • April 22, 2018

"Worked great from the first night I took it. The next morning I felt calmer and more mentally and emotionally stable. It helps me sleep and sleep well. I haven’t been formally diagnosed with anything yet, but I’m guessing I have BPD with depression and an anxiety disorder. This helped me with everything except for depression. I can’t rate it a perfect 10 because it seems to make me a little tired and unmotivated during the day. Also, I can’t seem to lose much weight on it, which is a bummer. My pdoc has tried other antipsychotics and ADs on me, but only Zyprexa (Olanzapine) has seemed to help at all."

9 / 10
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14 Report
  • Res...
  • Taken for 1 to 6 months
  • August 29, 2018

"I've been taking olanzapine 5 mg for about a month now, and I have gained 5 pounds. I only think of food, now I exercise a lot so I don't gain any more weight. I had very bad anxiety and suicidal thoughts and tried to commit suicide by taking an overdose of pills. When I was in the hospital, they gave me olanzapine. I feel much better, but I'm up extremely early, like 5:00 a.m. I feel more positive, and my thoughts are clearer. I am restless and want to keep moving and doing stuff, it can be exhausting, but as long as I feel better."

9 / 10
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17 Report
  • Ale...
  • Taken for 1 to 6 months
  • December 15, 2016

"This drug makes you gain a ridiculous amount of weight in just a few days. I've been taking Zyprexa for 2 months and gained almost 9 kg. It's terrible because of its side effects. As someone who was just at the right weight for my height, I'm afraid I'll not stop gaining weight and my borderline and depression will get worse. I feel self-conscious about my body now, I feel fat, and my anxiety is also getting worse. Sadly, I can't recommend this medication."

5 / 10
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16 Report
  • Bex...
  • July 23, 2017

"Very negative experience; I was on this medication for about 6 months to help with my anxiety levels and emotional turbulence. At the beginning of starting this medication, I was underweight. Six months on, I gained a lot of weight; I looked chubby, especially in my face. I was not happy with this significant weight gain; I also didn't feel it was helping with my mental health either. I stopped taking olanzapine nearly a year and a half ago. I have been working very hard to lose weight, and I'm getting there. However, my self-esteem has shattered; I don't like my body, and I am very self-conscious - this is all due to the weight gain from olanzapine. My advice is that if you are offered this medication, do your research first & exercise."

3 / 10
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16 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.

Learn more about Borderline Personality Disorder

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