Nystatin and Upset Stomach: What Users Say

• Kay...
• June 30, 2019

For Oral Thrush "I was on antibiotics for an extended time and after 4 months, I developed thrush. After starting this medicine, I noticed my mouth became extremely dry, especially at night while sleeping. My tongue had a funny burning sensation and everything tasted odd. Has anyone else had this same problem? Also, I got really bad diarrhea and stomach cramps."

• But...
• Taken for less than 1 month
• July 29, 2021

For Oral Thrush "It took 7 full days, 5 ml, for my oral thrush infection to clear. The usual time is 2-3 days, but since I'm immunocompromised, it took me longer to heal. I had only a stomach ache for 2 out of the 7 days while on this medication. No other symptoms!"

• bai...
• Taken for less than 1 month
• May 24, 2021

For Oral Thrush "I took it as a swish and spit for thrush. After a few days, I developed dry mouth and a bit of burning after I took it. Some stomach cramps also occurred. None of these side-effect symptoms were too much, and I finished a 2-week prescription."

• SND...
• Taken for less than 1 month
• January 18, 2023

For Oral Thrush "I developed oral thrush after being on antibiotics and methylprednisolone for oral surgery. I was prescribed nystatin rinse and was told to rinse and spit and not swallow, which I followed. It almost immediately made me dizzy and lightheaded. My stomach was upset and gurgling. After the second time taking it, I had diarrhea three times. My surgeon couldn’t understand how I could get diarrhea and GI upset if I wasn’t swallowing… but I was. It was clear when my stool was orangey-yellow like nystatin. I was then advised to stop and try fluconazole. Currently taking that with no issues (only taken it twice) and improvement but still working on it."

• SND...
• Taken for less than 1 month
• January 18, 2023

For Oral Thrush "I developed oral thrush after being on antibiotics and methylprednisolone for oral surgery. I was prescribed nystatin rinse and was told to rinse and spit and not swallow, which I followed. It almost immediately made me dizzy and lightheaded. My stomach was upset and gurgling. After the second time taking it, I had diarrhea three times. My surgeon couldn’t understand how I could get diarrhea and GI upset if I wasn’t swallowing… but I was. It was clear when my stool was orangey-yellow like nystatin. I was then advised to stop and try fluconazole. Currently taking that with no issues (only taken it twice) and improvement but still working on it."

• Ano...
• Taken for less than 1 month
• August 17, 2025

For Oral Thrush "Nystatin is the worst treatment option available for oral thrush. This medication caused me to feel nauseated, gave me a severe migraine, fever, dizziness, and upset stomach. I had to stop taking it. The Daktarin Oral gel is discontinued in the UK, this was the only thing that works!!!! Three courses of Fluconazole antibiotics I’ve taken due to my intolerance to Nystatin and nothing else is working. A waste of NHS money and time. Before, you could walk in and buy Daktarin from a pharmacy and actually treat the issue. Instead, I have had to go through numerous GP and pharmacy visits and medications, each time feeling awful, and still, I can’t get rid of the oral thrush. GPs and pharmacists all seem surprised that I had such a severe reaction to this medication, however, a bit of research online suggests others are also suffering the same side effects."