Nystatin and Diarrhea: What Users Say

• Kay...
• June 30, 2019

For Oral Thrush "I was on antibiotics for an extended time and after 4 months, I developed thrush. After starting this medicine, I noticed my mouth became extremely dry, especially at night while sleeping. My tongue had a funny burning sensation and everything tasted odd. Has anyone else had this same problem? Also, I got really bad diarrhea and stomach cramps."

• Say...
• Taken for less than 1 month
• April 17, 2021

"Was told to do an oral rinse with nystatin a few times a day for thrush. About 1-2 days in, and I have really bad diarrhea... ended up pooping in my pants about 3 days into the treatment. Thank goodness I was home. Will be calling my doctor. Not good if you have chronic intestinal/stomach problems. Also, tastes so terrible I almost vomit every time I take it. So definitely not worth it. Doesn’t even look like it’s improving anyway."

• SND...
• Taken for less than 1 month
• January 18, 2023

For Oral Thrush "I developed oral thrush after being on antibiotics and methylprednisolone for oral surgery. I was prescribed nystatin rinse and was told to rinse and spit and not swallow, which I followed. It almost immediately made me dizzy and lightheaded. My stomach was upset and gurgling. After the second time taking it, I had diarrhea three times. My surgeon couldn’t understand how I could get diarrhea and GI upset if I wasn’t swallowing… but I was. It was clear when my stool was orangey-yellow like nystatin. I was then advised to stop and try fluconazole. Currently taking that with no issues (only taken it twice) and improvement but still working on it."