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Nystatin use while Breastfeeding

Drugs containing Nystatin: Mycostatin, Nystop, Mycolog II, Mycostatin Topical, Nyamyc, NTA, Nilstat, Bio-Statin, FIRST Duke's Mouthwash, Nyst-Olone II, Show all 25 »Tri-Statin II, Myco-Triacet II, Myco Biotic II, Mycasone, Mytrex, Mycogen II, Pediaderm AF, Nyata, Pedi-Dri, FIRST Mary's Mouthwash, Nystex, Nystat-Rx, Mycostatin Pastilles, FIRST BXN Mouthwash, Mycomar

Medically reviewed by Last updated on Apr 6, 2019.

Nystatin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although no information exists on the milk excretion of nystatin, it is virtually unabsorbed orally, therefore most reviewers and clinicians consider it acceptable for use in nursing mothers, including topical application to the nipples.[1][2][3] Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[4] Any excess cream should be removed from the nipples before nursing. Nystatin is less effective than other topical agents for the treatment of thrush.[5][6]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Systemic) Amphotericin B, Fluconazole, (Topical) Clotrimazole, Miconazole


1. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001;17:160-6. PMID: 11847833

2. Ilett KF, Kristensen JH. Drug use and breastfeeding. Expert Opin Drug Saf. 2005;4:745-68. PMID: 16011452

3. Brent NB. Thrush in the breastfeeding dyad: results of a survey on diagnosis and treatment. Clin Pediatr (Phila). 2001;40:503-6. PMID: 11583049

4. Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. PMID: 14623482

5. Huggins KE, Billon SF. Twenty cases of persistent sore nipples: collaboration between lactation consultant and dermatologist. J Hum Lact. 1993;9:155-60. PMID: 8260031

6. Hoppe JE, Hahn H. Randomized comparison of two nystatin oral gels with miconazole oral gel for treatment of oral thrush in infants. Antimycotics Study Group. Infection. 1996;24:136-9. PMID: 8740106

Nystatin Identification

Substance Name


CAS Registry Number


Drug Class

Breast Feeding


Antifungal Agents

Administrative Information

LactMed Record Number



Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Further information

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