Nystatin topical Side Effects
For the Consumer
Applies to nystatin topical: vaginal cream, vaginal tablet
Other dosage forms:
Along with its needed effects, nystatin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking nystatin topical:Rare
- Vaginal burning or itching not present before use of this medicine
For Healthcare Professionals
Applies to nystatin topical: topical cream, topical kit, topical ointment, topical powder, vaginal tablet
Dermatologic side effects associated with nystatin topical powder, cream, and ointment have included skin irritation, burning, itching, rash, eczema, and pain on application in less than 0.1% of patients.[Ref]
Genitourinary side effects associated with nystatin vaginal tablets have included vaginal irritation, burning, and itching. At least one case of severe vulvovaginitis has also been reported.[Ref]
A 64-year-old female experienced severe vulvovaginitis while receiving intravaginal nystatin therapy for Candida glabrata infection. She was administered nystatin vaginal tablets, 100,000 units twice daily for 14 days. She returned immediately after having completed the course complaining of intense skin rash in the vulvar area accompanied by severe irritation, burning, and itching. Therapy with a hydrocortisone cream and intramuscular betamethasone dipropionate was initiated. A week later, she had marked improvement with clearing of the vulvovaginal erythema and edema.[Ref]
Hypersensitivity side effects associated with nystatin topical powder, cream, and ointment have included allergic reactions and allergic contact dermatitis in less than 0.1% of patients. Stevens-Johnson syndrome has also been reported.
1. Wasilewski C Jr "Allergic contact dermatitis from nystatin." Arch Dermatol 102 (1970): 216-7
2. Quirce S, Parra F, Lazaro M, Gomez MI, Sanchez Cano M "Generalized dermatitis due to oral nystatin." Contact Dermatitis 25 (1991): 197-8
3. Garty BZ "Stevens-Johnson syndrome associated with nystatin treatment." Arch Dermatol 127 (1991): 741-2
4. "Product Information. Mycostatin Cream, Mycostatin Topical Powder (nystatin)." Westwood Squibb Pharmaceutical Corporation, Eatontown, NJ.
5. "Product Information. Mycostatin Pastilles (nystatin)." Ernest Jackson & Co., Ltd., Crediton, Devon, England, .
6. Lang E, Goos M "Combined allergy to tolnaftate and nystatin." Contact Dermatitis 12 (1985): 182
7. Hills RJ, Ive FA "Contact sensitivity to nystatin in Timodine." Contact Dermatitis 28 (1993): 48
8. de Groot AC, Conemans JM "Nystatin allergy. Petrolatum is not the optimal vehicle for patch testing." Dermatol Clin 8 (1990): 153-5
9. Wasilewski C Jr "Allergic contact dermatitis from nystatin." Arch Dermatol 104 (1971): 437
Some side effects of nystatin topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
More about nystatin topical
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- Drug class: topical antifungals
- Nystatin topical
- Nystatin Cream and Ointment
- Nystatin Topical Powder
- Nystatin Topical (Advanced Reading)
- Nystatin Vaginal (Advanced Reading)
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