Pamelor and Constipation: What Users Say

• Anonymous
• Taken for 1 to 6 months
• October 12, 2012

For Pain "I have calf pain (mainly when sitting) due to small fiber neuropathy. I tried Neurontin, Lyrica, Cymbalta...without any luck. Tramadol provided limited relief, but not nearly enough. Finally, I tried Pamelor and after a few weeks, the calf pain started to dissipate. I take 100mg/day, and the side effects have been pretty mild. The drowsiness tapered off after a few days, but the dry mouth and constipation go with the territory. I get occasional tinnitus as well."

• bir...
• October 17, 2010

For Migraine Prevention "I've suffered from migraines for 14 years and have taken numerous medications for prevention including Topamax. Topamax caused MANY bad, undetermined health issues. My Internal Medicine physician took me off Topamax and put me on 25 mg of Nortriptyline for migraine prevention. Almost immediately, I had relief from migraines, had clarity of mind even better than ever before, had a great attitude. I felt 'normal' for the first time in my life. This medication caused noticeable urinary retention, constipation, and increased appetite which caused weight gain. Due to weight gain, I was changed to Pristiq. Migraines have returned. I intend to ask to be put back on Nortriptyline and will have to alter diet and exercise."

• Suz...
• Taken for 6 months to 1 year
• September 4, 2018

For Depression "25 years ago. I took Pamelor for postpartum depression. It worked for the depression but had to stop taking because my stools became hard as rocks and were difficult to pass. I have had irritable bowel syndrome since as a result. I also gained about 40 pounds, and no matter how much I diet or exercise, I cannot lose the weight."

• the...
• Taken for less than 1 month
• January 8, 2017

For Depression "I was tried on this for major depression. After 2 weeks on 50 mg per night, I couldn't handle it anymore. I ended up going to the ER because my heart was racing. I was at 125/130 beats per minute. I'd only been getting a few hours of sleep each night in those 2 weeks, and experienced the heart racing, brain short circuits, insomnia, anxiety, severe constipation, extreme thirst, and an overall feeling of disconnect from aliveness. As a teenager, I took Doxepin and Elavil too, and they were slightly better, but not much. These TCAs should be a last resort, like Thorazine and Lithium. Seroquel is much better. Good luck to my fellow sufferers!"

• Rkp...
• Taken for less than 1 month
• May 23, 2019

"I have plantar fasciitis, so to walk was killing me. I could barely walk. It sidelined me for simple outings with my family. Had to sit with my feet up all the time. Nothing but pain. My doctor gave me Pamelor, and he told me it would help the nerve pain. I was up and going after taking Pamelor for a week, no pain. I’ll take the low ringing and the constipation over not enjoying life again."

• Anonymous
• Taken for 6 months to 1 year
• January 28, 2013

For Migraine Prevention "I took this medicine for migraine and nerve pain. I had to stop taking because it caused very bad cotton mouth and constipation."